ShorterLab

How close are scientists to stopping ALS in its tracks?drugdiscoverynews.com/how-close-are-…

Inspiring Words from @YentliSA, at #ADPD2026! 👏 We are thrilled to have Yentli, an MD-PhD candidate at University of Pennsylvania, back with us at #ADPD2026! Last year in Vienna, Yentli attended the conference and made meaningful connections, which led to exciting collaborations and new projects she’s working on today. 🌟 AD/PD™ played a pivotal role in her career path, opening doors to new collaborations and inspiring her work towards finding better treatments for these devastating diseases. 🎥 Watch the full recap video to hear more from Yentli as she shares her inspiring vision for tackling ALS and FTD. @TargetALS_fdn @BrainXell_Inc @esrfsynchrotron💯 #alzheimers #dementia

Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans: journals.plos.org/plosbiology/ar…

Why do we have so many different transcripts? journals.plos.org/plosbiology/ar…

A gradient green-beard gene in fission yeast: link.springer.com/article/10.103…

Phase separation of PGL-3 driven by structured domains that oligomerize and interact with RGG motifs: link.springer.com/article/10.103…

ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences: link.springer.com/article/10.103…

Protein overabundance is driven by growth robustness | Science Advances science.org/doi/10.1126/sc…

Happy first day of Spring, Philly. 🌷🌸 Pretty soon, our City will be looking like this!

Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread | Science Advances science.org/doi/10.1126/sc…

Amino acid composition drives aggregation during peptide synthesis: nature.com/articles/s4155…

We've made it through winter, happy spring equinox! 🌷🐝

Philly

Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP‐43 low‐complexity domain - Walker - 2026 - Protein Science - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/pr…

It turned out to be an absolutely beautiful night on the Schuylkill River

Somatic gene mutations in the motor cortex of patients with sporadic amyotrophic lateral sclerosis: academic.oup.com/brain/article/…

The Hsp40 cochaperone DNAJC7 regulates polyglutamine aggregation and exhibits context-dependent effects on polyglycine aggregation - Journal of Biological Chemistry jbc.org/article/S0021-…

HIV-1-encoded circular RNA enhances viral transcription through Tat binding: nature.com/articles/s4156…

Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection: nature.com/articles/s4155…

How could you not love this city, man

(Lnc)ing MALAT1-SRSF1 condensates to hypoxia-induced RNA alternative splicing and cancer: Molecular Cell cell.com/molecular-cell…