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Hypoxia rescues complex 1-associated disease caused by proteostatic defects: nature.com/articles/s4225…
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ShorterLab
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ShorterLab
@ShorterLab
Countering deleterious phase transitions in ALS/FTD, PD, AD, and related disorders @Penn @PennMedicine @bb_upenn @BMBGGUPENN @PGGUPenn @PennNGG @CAMBUpenn
University of Pennsylvania Katılım Ocak 2012
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In @eLife: Cytoplasmic circular dsDNA is a key constituent of stress granules doi.org/10.7554/eLife.…
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High-resolution structure of monomorphic Aβ1-40 fibrils | PNAS pnas.org/doi/10.1073/pn…
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Liquid–liquid phase separation enables chromatography-free purification and high-performance spidroin-amyloid hybrid silk fibers | PNAS pnas.org/doi/10.1073/pn…
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Dopaminergic neurons preferentially accumulate mtDNA rearrangements | PNAS pnas.org/doi/10.1073/pn…
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Repurposing trazodone for Alzheimer’s disease to modulate soluble ST2 levels and alleviate Alzheimer’s pathology | PNAS pnas.org/doi/10.1073/pn…
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Targeted α-synuclein mRNA degradation by PMO-based RNA-degrading chimeras | PNAS pnas.org/doi/10.1073/pn…
Striatal neuron dysfunction in C9ORF72-FTD/ALS is driven by AIS and potassium channel dysregulation: Cell Reports cell.com/cell-reports/f…
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Intrathecal (G4C2)149 delivery in C9orf72-deficient mice yields mild motor dysfunction and ALS/FTD pathological hallmarks: link.springer.com/article/10.118…
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Phase separation and protein aggregation in neurodegenerative diseases sciencedirect.com/science/articl…
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TAF15 amyloids propagate via defined motifs in a prion-like fashion: nature.com/articles/s4146…
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Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs: nature.com/articles/s4159…
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An anti-PMEL antibody−drug conjugate with a Gq/11 inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial: nature.com/articles/s4159…
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TDP-43: [GU]-ardian of the transcriptome: link.springer.com/article/10.118…
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Single-molecule imaging reveals cytoplasmic translation of P granule-enriched mRNAs in C. elegans biorxiv.org/content/10.648…
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TDP-43 dysfunction facilitates the pathological conversion of tau: link.springer.com/article/10.118…
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Great commentary from @jennagregory488 on use of TDP43 as a biomarker
link.springer.com/article/10.118…
Relates to phase 2 PrimeC Paradigm trial paper
jamanetwork.com/journals/jaman…
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PrimeC in Amyotrophic Lateral Sclerosis jamanetwork.com/journals/jaman…
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CAR Treg therapies for neurodegenerative diseases: iScience cell.com/iscience/fullt…
Cambridge, MA 🇺🇸 English
Proximity to Golf Courses and Risk of Parkinson Disease jamanetwork.com/journals/jaman…
Cambridge, MA 🇺🇸 English