ShorterLab

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration: science.org/doi/10.1126/sc…

TDP-43 protein clumping is a major driver of neurodegenerative disease. But in a new study in @Science, @Penn @ShorterLab’s Copley et al. developed a therapeutic strategy in a mouse model in which short RNAs work as chaperones that bind to and inhibit TDP-43 aggregation: ow.ly/H1nH50YXRO3

Penn

Penn

Penn

Penn

High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects, exciting work from @JackrelLab: Molecular Cell cell.com/molecular-cell…

MAMA THERE GOES THAT MAN!

A TerminaTOR of mTORC1 signaling: nature.com/articles/s4158…

Genetically targeted mTORC1 inhibitor reveals transcriptional control by nuclear mTORC1: nature.com/articles/s4158…

Fast folding of anthrax lethal factor N-terminal domain independent of proline isomerization: Biophysical Journal cell.com/biophysj/fullt…

Perinuclear Actin Airbag Protects the Nucleus from Shock: Biophysical Journal cell.com/biophysj/fullt…

Cell-type-specific APOE4 cascade across the Alzheimer’s disease continuum: Neuron cell.com/neuron/fulltex…

Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming: nature.com/articles/s4159…

An RNA chaperone breaks up TDP-43 deposits in cells and preserves neurons in mice, suggesting potential as a therapy. #amyotrophiclateralsclerosis #frontotemporaldementia #alzheimersdisease @Penn ow.ly/5ynr50YZfA1

For TDP-43 Aggregates, Breaking Up Is No Longer Hard to Do alzforum.org/news/research-…

Investigating the functional components of YAP condensates | Molecular Biology of the Cell molbiolcell.org/doi/10.1091/mb…

Ultrastructural studies reveal a new role for JIP3/MAPK8IP3 in endo-lysosomal maturation within the neuronal cell body | Molecular Biology of the Cell molbiolcell.org/doi/10.1091/mb…

In vivo adenine base editing ameliorates Dravet syndrome phenotypes in a mouse model | Science Translational Medicine science.org/doi/10.1126/sc…

Autophagy is required for dopaminergic axon development and confers their responsiveness to guidance cues. jneurosci.org/content/early/…

Large-scale discovery, analysis and design of protein energy landscapes: nature.com/articles/s4158…