Sleegers Lab

If you are interested to see more from the Sleegers Lab, please check out our account on Bluesky (sleegerslab.bsky.social): bsky.app/profile/sleege…. This Twitter account will no longer be active. See you there! 🦋

For the FFBD Faculty Research day, the @UAntwerpen interviewed our Ph.D. student @CelesteLaureys1 on her work on the genetic exploration of Alzheimer’s disease hallmarks and neuropathological lesions. Listen to her passionately explain her research! 🧠🧬open.spotify.com/episode/0isr8p…

🤝@MariekeVromman ⭕️🧬 Very happy to share that our review on extracellular circRNAs is now out in WIREs RNA! We summarize the little that is known, navigate their daunting literature, and dive into hypotheses on their extracellular existence! onlinelibrary.wiley.com/share/author/T…

A bit late to the party, but @TijsWatzeels and @CelesteLaureys1 presented their wonderful research on a very successful first UAntwerp Nanopore Day some weeks ago! See you next time!

Our postdoc @JVerwilt presented his work on long-read exRNA sequencing today at LRUA in Uppsala. What an amazing venue! 🇸🇪 #LRUA24

Many thanks and congratulations to all authors who contributed to this great collaborative paper @neuropatho_lab @Neuropathology @VIBLifeSciences @UAntwerpen @KU_Leuven @CMN_VIB Stay tuned for more exciting findings from the broader new analyses by @CelesteLaureys1 soon! ⌛️

In this study, we reveal how Alzheimer's disease risk variants discovered in large-scale case-control genome-wide association studies (GWAS) map to the diverse underlying neuropathological features of the disease.

We are excited to share that our new paper, led by Celeste Laureyssen (@CelesteLaureys1), is now published in Acta Neuropathologica and available online!🧠🧬 Check out our new publication here: link.springer.com/article/10.100…

Talking long reads in Uppsala! Find the ever-enthusiastic @TijsWatzeels at his poster where he will draw you into the world of differential isoform usage in AD! 🧠🧬 #LRUA24

The last few days, one of our Ph.D. students @CelesteLaureys1 presented a poster on her research at @ECDOorg Conference focusing on “Cell Death at the Crossroads of Neurodegeneration and Cancer". Stay tuned for the follow-up paper soon to be published! 🥳🧐#ECDO2024

Very happy to see our new paper on our new tool for comprehensive analysis of single-cell RNA long-reads, 𝙨𝙘𝙮𝙬𝙖𝙡𝙠𝙚𝙧, published! 🧬 Paper: academic.oup.com/bioinformatics… GitHub: github.com/derijkp/scywal… (A bit late but just in time for Nanopore Research Day Antwerp today! 😊)

#AAIC24! Join us tomorrow (August 1) at 9AM EDT for the session "Basic Science and Pathogenesis LPR: Alternative phenotypes and genetic variation to decipher genomics of ADRD". It will feature 6 great presentations, and I will be co-chairing with ⁦@clausuemoto⁩. See you! 😊

Today we have our amazing team members, Celeste Laureyssen (@CelesteLaureys1, #76), and Fahri Küçükali (@maegsul, #74) presenting their latest research. Don't miss the chance to learn more about their wonderful work. #Alzheimers #AAIC24 #AAIC2024 #GWAS #Philly 🧠🧬

Our team member, Lara De Deyn (@laraonearth), is presenting her latest research in poster #60 today. Don't miss the chance to learn more about her work. See you there! #Alzheimers #AAIC24 #AAIC2024 #singlecell #singlenuclei #Philly 🧠🧬

Happy and excited to be in Philly for #AAIC24! @alzassociation Come find us during the oral and poster presentations by our team members Lara De Deyn (@laraonearth), Celeste Laureyssen (@CelesteLaureys1), and Fahri Küçükali (@maegsul) on our recent work! 🧠🧬

Happy to see our preprint online! Have a look at it if you are interested in integrative multiomic analyses to nominate prioritized Creutzfeldt-Jakob Disease risk genes and mechanisms 🧬 medrxiv.org/content/10.110…

A genome‐wide association meta‐analysis of all‐cause and vascular dementia - Fongang - Alzheimer's & Dementia - Wiley Online Library 🙏🙏👏wonderful collaboration!! alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Multiomic Analyses Direct Hypotheses for Creutzfeldt-Jakob Disease Risk Genes. New paper looking at transcriptomic, proteomic and single cell expression modelling to refine possible mechanisms of CJD risk factors. 🧵 medrxiv.org/content/10.110…

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing Congrats Cyril, @maegsul and all authors! Another milestone for FTLD and TDP-43 genetics! medrxiv.org/content/10.110…