Sorek Lab

1.1K posts

Sorek Lab

@SorekLab

The Sorek Lab

Israel Beigetreten Ocak 2015

267 Folgt8.7K Follower

Sorek Lab retweetet

IdoAmitLab@IdoAmitLab·22 Oca

What if we could turn the tumor’s deadliest tricks against it? New @Cancer_Cell: Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells. Led by @GalYagel, @D_Rimini & @MVLocquenghien (1/15) cell.com/cancer-cell/ab…

English

10.9K

Sorek Lab retweetet

Erez Tzvi Yirmiya@ErezTzvi·4 Ara

Happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life go.bsky.app/redirect?u=htt…

English

Sorek Lab retweetet

Romi Hadary@HadaryRomi·25 Ağu

📢 Preprint out! Together with @reneechang and the amazing @SorekLab , we explored viral sponges to map their diversity and function. Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris! biorxiv.org/content/10.110…

English

3.2K

Sorek Lab retweetet

Nitzan Tal@Nitzan_T·13 Tem

📢Preprint out! Excited to share my final work from the @Soreklab! We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery. Found 3 new families targeting immune signaling!

English

175

19.3K

Sorek Lab retweetet

Patrick Hsu@pdhsu·15 May

Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new @arcinstitute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

Patrick Hsu@pdhsu

What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

English

193

883

199.2K

Sorek Lab retweetet

Dziugas Sabonis@d_sabonis·30 Nis

Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork! nature.com/articles/s4158…

English

4.6K

Sorek Lab@SorekLab·30 Nis

@IsbergRalph Thank you Ralph! I am honored to join the NAS.

English

327

Ralph Isberg@IsbergRalph·29 Nis

Congratulations to Rotem Sorek (@SorekLab) on your election to the US National Academy of Sciences as an International Member!!

English

793

Sorek Lab retweetet

BiomX (NYSE:PHGE)@BiomX_Inc·4 Şub

🗓️Tomorrow! Ariel Cohen, VP Development Projects will present "The Challenges & Opportunities of the Development Pathway for Phage Therapy" 🦠at the Antimicrobial Chemotherapy Conference 2025, join virtually 14:35 CET! Register👉 bsac.eventsair.com/antimicrobial-… #PhageTherapy #Antibiotics

English

2.5K

Sorek Lab retweetet

Ilya Osterman@IlyaOsterman·31 Oca

Another cADPR isomer involved in bacterial immunity has been discovered. For me, N7 was the least expected position; I was sure it would be N3, but no... So, there are two more positions for cyclization that should be discovered: N3 and -NH2. More Thoeris systems are waiting! :)

Sorek Lab@SorekLab

Now published @ScienceMagazine: TIR signaling activates caspase-like immunity in bacteria We report a new immune molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase Congrats @FrancoisRousset & @IlyaOsterman! science.org/doi/10.1126/sc…

English

4.5K

Sorek Lab retweetet

Systems_Immunology_WIS@Sys_Immunology·31 Oca

Congrats our very own @Sys_Immunology member PI @TanaWein for the impressive new paper @Nature together with @SorekLab- Shedding yet another piece of the (inflammasome-related) origins of immunology in bacteria!! Proud of you Tana and team! nature.com/articles/s4158…

English

3.4K

Sorek Lab@SorekLab·31 Oca

English

156

36.8K

Sorek Lab retweetet

Seth Shipman@seth_shipman·31 Oca

We just posted a new preprint where we found retrons in bacteria out in the real world, in dirt and water. We describe the first retrons in a handful of new species, show how they defend against phages, and use them to edit genomes. Read about it here: biorxiv.org/content/10.110…

English

7.5K

Sorek Lab@SorekLab·30 Oca

Read more about our discovery in the thread by lead author @TanaWein 👇 x.com/TanaWein/statu…

Tanita Wein@TanaWein

Very happy our paper on CARD domains in gasdermin anti-phage defense systems is now published in @Nature 🥳 Thanks to all the people involved especially the Kranzusch lab and @SorekLab nature.com/articles/s4158…

English

1.8K

Sorek Lab@SorekLab·30 Oca

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems Congrats @TanaWein! Thanks Kranzusch lab! tinyurl.com/CA88DD

English

172

10.7K

Sorek Lab@SorekLab·26 Oca

@cbuch2 @IsbergRalph @theNASciences Thank you Carmen! 🙏

English

119

Carmen Buchrieser@cbuch2·26 Oca

@SorekLab @IsbergRalph @theNASciences Wow, congratulations Rotem, well désertés

Français

135

Sorek Lab@SorekLab·23 Oca

Thank you @theNASciences 🙏 It is an immense honor to be included in the same list as the giants in microbiology who received the Selman A. Waksman Award

National Academy of Sciences@theNASciences

We are honoring Rotem Sorek of @WeizmannScience with the 2025 Selman A. Waksman Award in Microbiology for groundbreaking discoveries on the immune system of bacteria. Congratulations! Learn about his research: nasonline.org/award/selman-a… #NASaward #microbiology

English

202

14.5K

Sorek Lab@SorekLab·25 Oca

@ptrtsvetkov @theNASciences Toda Amraam!

Eesti