Structural Biology at St. Jude Children's Hospital

Our goal is to understand life and disease at atomic detail. We use #cryoEM, #NMR spectroscopy, #Xray #crystallography, #SingleMolecule spectroscopy, #MassSpectrometry and #computational tools to determine the mechanisms underpinning biological function.

Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: cell.com/cell/fulltext/… Explore this amazing resource here: yslproteomics.shinyapps.io/tissuePPT

Beautiful work from @JunminPengLab, presenting comprehensive proteomics and phosphoproteomics data from 5 different mouse models for Alzheimer’s disease at different ages, with comparison to human data and many insights, out in @NatureComms Congrats @YarbroJay & all coauthors!

Congrats to our newest faculty member, Christoph Gorgulla @StJudeResearch, and colleagues @UofT @InSilicoMeds, for work just out @NatureBiotech — using quantum computing to design small molecules that inhibit KRAS. #OpenAccess nature.com/articles/s4158…

As 2024 ends, we’re celebrating key discoveries by St. Jude scientists. In this #ResearchWrapUp, we’re highlighting advances in #MolecularBiology that connect basic science to better health.

Beautiful work from @kriwacki in @NatureComms! Eric Gibbs and colleagues study the interactions between nucleolar protein NPM1 and tumor suppressor p14-ARF within condensates, revealing new regulatory mechanisms. #NMR #SAXS nature.com/articles/s4146…

We have exciting news to share! Abhay Kotecha (@abhaykot) is joining us as Senior Director of Technologies for Cryo-EM and Cryo-ET. We're thrilled to have him continue his great work in #CryoET, building on his innovation at @thermosciEMSpec. Welcome to @stjuderesearch, Abhay!

📢Don't miss out on our plenary #seminar next week, with Dr. @TanjaMittag, from @StJudeStructBio @StJudeResearch: 🤝Hosted by Dr. @xsalvatella1 (#IRBBarcelona-@icreacommunity). Register now!👉shorturl.at/9QRXF #BarcelonaBiomed

St. Jude names M. Madan Babu, PhD, as Chief Data Scientist. He’ll lead the new Office of Data Science, advancing biomedical research with 115 new roles. His work will help integrate vast datasets and improve patient care. #DataScience #BiomedicalResearch ow.ly/gQbN50TAASu

Congrats to @SchargelRichard, Zuhaib Qayyum, Ajay Singh, Ravi Kalathur – go PTC!!!

Still hot off the press — @kellogg_liz and colleagues present the first structure of a Fanzor2! Fanzors are eukaryotic RNA-guided DNA endonucleases. With the available Fanzor1 structures, the new work offers a comprehensive view of the family's evolution nature.com/articles/s4159…

We end the symposium with closing remarks by Madan Babu @m_madan_babu. We thank all speakers and session chairs, and hope all participants enjoyed the exciting science and stimulating discussion. We look forward to continuing the conversation at the reception tonight and beyond!

Final session is on designing function, chaired by @NancyRGough @Markus Weingarth, @AlissaHummer and Alexandre Zanghellini @biopraxis talk about the latest advances in antibiotic and protein design, and glimpse into the future!#NMR #antibiotics #MachineLearning #AI #proteindesign

Our @TanjaMittag chairs the upcoming session exploring new approaches, featuring Stephan Rauschenbach @ESIBDLab, @IvetBahar and Francis O'Reilly @FJ_OReilly #samplepreparation #MassSpectroscopy #ComputationalBiology #proteomics #SystemsBiology

We continue to explore #membrane signaling in the next session, chaired by Chia-Hsueh Lee @TheCHLeeLab, featuring talks by Willow Coyote-Maestas @willowcoyote, Nurunisa Akyuz and Justin English @JGEnglishLab #transporters #channels #mechanosensation #GPCR

Very excited about the Keynote Lecture by Rod MacKinnon from @RockefellerUniv and HHMI, introduced by former mentee Chia-Hsueh Lee @TheCHLeeLab The auditorium is jam packed! #ionchannel #membrane signaling

Our very own Liz Kellogg @kellogg_liz kicks off the next session, focused on nuclear transactions. We have 3 outstanding speakers: Yuh Min Chook @yuhminchook, Tatiana Kutateladze @CUAnschutz and Juli Feigon @FeigonLab #cellnucleus #chromatin #telomerase

Looking forward to session on decoding protein structure and disorder, chaired by Scott Blanchard @TheBlanchardLab and featuring @TanjaMittag, Edward Lemke @LemkeLab and Kresten @LindorffLarsen #integrative #IDPs #condensates

Session on #microbes and #pathogens, with more spectacular #CryoEM and #CryoET! We have Susan Lea @S_M_Lea and the bacterial flagellum, and Mimi Ho @mimi1inh on an integrated approach to understand the native translation machinery in situ in #malaria parasites. #molecularmachines

We are starting our 3rd Structural and Computational Biology Symposium! Babis Kalodimos @KalodimosLab opens the event, followed by a session on structural cell biology chaired by Yiorgo Skiniotis, with Abhay Kotecha @AbhayKot and Shyamal Mosalaganti @s_mosalaganti #CryoET

@AhmedAdelEzat In person only this year. We might change the format next time

@StJudeStructBio It is in person meeting or will be streamed online

All ready for our upcoming symposium here at St. Jude. We have a stellar lineup of speakers and over 250 registered attendees! Looking forward to two days of exciting science!