Tooth Morphogenesis and Differentiation

This paper took us 13 years and is one of the longest papers ever in Cell. Check it out & judge for yourself cell.com/cell/fulltext/…

scMultiSim is a comprehensive single-cell and spatial data simulator generating realistic multi-omics data based on modeling gene regulatory networks, cell-cell interactions, and other biological and technical factors nature.com/articles/s4159…

New article from our lab on the importance of squamate models for understanding key dental features of vertebrates is already online in @Dev_Bio_Journal as a pre-proof @BIOTECH_UH @HiLIFE_helsinki @helsinkiuni doi.org/10.1016/j.ydbi…

It turns out...Komodo dragons have iron-coated teeth! nature.com/articles/s4155… Their serrations and tips pop into the mouth with an orange hue. Using different techniques, we show that these iconic lizards have special iron-rich coatings on each tooth, keeping them razor sharp!

Snakes have unique body plans, esp. in the skull. Embryonic description of Japanese rat snake reveals early ossification of palatine & pterygoid for swallowing large prey. Rapid prootic bone ossification aids in ground-borne sound detection Nojiri et al.: doi.org/10.1002/ar.255…

Despite extensive study on Smilodon fatalis, their masticatory behaviors remain debated. Using osteological proxies from extant felids, researchers estimate gape & bite force, suggesting S. fatalis killed large prey with shearing bites. Deutsch et al.: doi.org/10.1002/ar.255…

As part of the upcoming @LeverhulmeTrust research project on lizard enamel evolution, I will be recruiting a new (UK) PhD student for a 1st October start! If you or someone you know is interested, here is the advert link: findaphd.com/phds/project/e…

Proud to announce one of my PhD chapter is out in #OpenAccess in @CurrentBiology with @Val_Fisch @DavideTamagnin4 & @MargotMichaud00 🥳 Interested in evolutionary patterns of cat-like carnivorans? 🦁🔪 Here is a thread 🧵1/X doi.org/10.1016/j.cub.…

Really interesting new study by @Tseng_ZJ on prolonged canine eruption in saber-toothed carnivores! "...the timing of the eruption of the sabers has been tweaked to allow a double-fang stage"  Media article: phys.org/news/2024-04-e… @AnatRecord article: anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar…

Really excited to present the results of a great collaboration with the lab of @OphirKlein! 😃 A truly interdisciplinary effort, led by Neha and Pengfei, that reveals how tissue pressure sets the main tooth signaling center. Out today in @NatureCellBio ➡️ nature.com/articles/s4155…

Really cool paper about a tooth loss reversion phenotype in zebrafish by blocking RA degradation during tooth development! pnas.org/doi/10.1073/pn…

Gain-of-function mutations in Fibroblast growth factor receptor-3 (#FGFR3) cause #achondroplasia. #Infigratinib, a FGFR1-3 inhibitor, improves #skeletal growth in achondroplasia models, but detrimentally affects #craniofacial and #dentoalveolar tissues doi.org/10.1002/dvdy.6…

Congrats to my former postdoc @IanETowle on our latest publication on tooth chipping and caries in fossil anthropoids. It's amazing how teeth can hold so much information about the lives of our ancestors 🥰 onlinelibrary.wiley.com/doi/10.1002/aj…

MicroCT scans reveal insights into the tooth replacement pattern of the enigmatic Charruodon tetracuspidatus, a #Triassic #cynodont. Early ontogenetic stage hints at potential taxonomic mysteries! New research by Carolina Hoffmann et al.: doi.org/10.1002/ar.253…

Excited to share our latest @Nature paper spearheaded by @YaelGruper identifying a new autoimmune disorder, characterized by impaired tooth development & generation of autoAbs against enamel matrix. It occurs in most AIRE def patients & ~1/3 of celiac kids nature.com/articles/s4158…

Mineralized #dental tissues such as #enamel and #dentin require tight transcriptional control of #matrix #protein secretion. Learn how the #odontogenic transcription factor #Msx2 regulates #enamalin during #amelogenesis and enamel biomineralization. doi.org/10.1002/dvdy.5… #Mouse

New genus and species characterized by distinctive molar morphology. #teeth #metatheria Crichton et al 2023 et al 2023 Scientific Reports: A probable #koala from the Oligocene of central #Australia provides insights into early diprotodontian #evolution doi.org/10.1038/s41598…

New paper on morphological disparity and enamel ultrastructure in odontocetes, from @MaryViglino work in NZ a few years back #womeninSTEM #LatinasinSTEM #oralbiology #dentistry nature.com/articles/s4159…

Insights gained from observing live and museum specimens help understand the chewing biology of hippos and yield instructions for reconstructing tooth positions in museum specimens. doi.org/10.1371/journa…