Vytaute Boreikaite

Our work on Pol II dephosphorylation and its connection to transcription regulation and mRNA 3' end processing by the Cleavage and Polyadenylation Factor (CPF) is now out in @MolecularCell!

Human mRNAs form globules in 3D and are prepared for export by the transcription-export complex. We are excited to share this and more mechanistic insights in our newest work, co-lead by the fantastic @bpachecofiallos and @MVorlandr. rdcu.be/c9e0f (1/9)

Fun times in the Passmore lab! Congratulations to @VBoreikaite who has just completed her PhD!

New work from @_M_Carminati shows that dephosphorylation of RNA polymerase II by CPF (the 3' end processing machinery) promotes Pol II dimerisation. @mcemremnv @MRC_LMB @ERC_Research

Work from @rodriguezmol on the role of Mpe1 in mRNA 3' end processing is now out in @MolecularCell ! This was a team effort including @FJ_OReilly @FagarasanHolly @EleanorSheekey @RappsilberLab @ERC_Research @MRC_LMB

And concluding #Microsymposium2022 with the #PhDworkshop prizes! 1st prize goes to @lisababalisa from @juliusbrennecke's lab at IMBA! The two 2nd prizes go to @VBoreikaite (@MRC_LMB) and @MakiGoesScience from our neighboring @gmivienna ! Congratulations to the awardees!

#Microsymposium2022 also features a #PhDworkshop, at the end of which one of the PhD candidate speakers will be selected for an #award Photo: @VBoreikaite (@MRC_LMB), #workshop part 1 @IMPvienna @gmivienna @MaxPerutzLabs @viennabiocenter #RNA #RNAbiology #symposium #PhD

Very excited to write this Outlook piece with @YoseopYoon for @GenesDev highlighting the groundbreaking work from Elmar Wahle and @lapassmore groups on reconstituting the human mRNA 3' processing in vitro! genesdev.cshlp.org/cgi/content/lo… genesdev.cshlp.org/cgi/content/lo… genesdev.cshlp.org/cgi/content/lo…

Vytaute's @VBoreikaite PhD work on reconstituting the activity of the human CPSF complex has now been published online 🎉. @GenesDev genesdev.cshlp.org/content/early/… (see previous thread for details)

@CJKay93 Done for the day.

Wordle 210 3/6 ⬜🟨🟨🟨⬜ 🟩⬜🟨🟩🟨 🟩🟩🟩🟩🟩

PolyA tails on eukaryotic mRNAs are added after co-transcriptional endonucleolytic cleavage of the pre-mRNA. @VBoreikaite has now reconstituted specific and efficient 3ʹ-endonuclease activity by human CPSF with purified proteins. @ERC_Research @MRC_LMB biorxiv.org/content/10.110…