Genes & Development

🚨 NEW ISSUE ALERT!!! 🚨 New Research articles online now at Genes & Development! Also in this issue, an Outlook on ATR in translesion synthesis, and a Review about the mechanisms controlling stem cell state exit. Click here to learn more: ➡️ genesdev.cshlp.org/content/40/13-…

🆕 ADVANCE ONLINE 🆕 REVIEW: Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship By Devesh Raizada and Ana Gomes ➡️ ow.ly/Xrt750ZunaW @lab_gomes @MoffittResearch @MoffittNews #cancer #metabolism

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Dual regulation of the unfolded protein response by IGF2BP3 during ER stress By Anisimova et al., and Elif Karagöz ➡️ ow.ly/xL7F50ZuomQ @alessandrick @ViennaBioCenter @MaxPerutzLabs @univienna @MedUni_Wien #ERstress #UPR #RNA

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Functional divergence of Capicua isoforms explains differential tissue vulnerability in neurological disease By Lee et al., and Huda Zoghbi ➡️ ow.ly/Tb6H50ZulEY @Haminhaminl @bcmhouston @bcmgenetics @hhmi_science #neurodevelopment

Dr. H Zoghbi, @Haminhaminl et al found that certain areas of the #Brain are more vulnerable to disease if a specific protein partnership is disrupted #capicua #ataxia #SCA1 @GenesDev @bcmhouston @TexasChildrens @bcmgenetics @bcm_neurosci bcm.edu/news/researche…

My former student and the lead author, @LVSoles, gave a brief introduction on our recent paper!

#ResultatScientifique🔎| La protéine LKB1 joue un rôle essentiel dans la formation du système nerveux entérique 🧠 ✍️ Sakina Torch & Chantal Thibert 📕 @GenesDev A lire sur CNRS Biologie 👉️ buff.ly/mq7v5oV

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: The basic helix–loop–helix transcription factor TCF4 recruits the Mediator complex to activate gonadal genes and drive ovarian development By O'Neil et al., and Blanche Capel ➡️ ow.ly/RpL850ZukTc @EleanoreVONeil @DukeU @DukeCellBiology

📽️ G&D Tapes 📽️ G&D Author, Lindsey Soles, tells us about how mRNA splicing and 3' end processing coordinate and compete to shape transcriptional output. In this issue of #genesdev: ➡️ genesdev.cshlp.org/content/40/13-… @LVSoles @YongshengShi @UCIrvine @UCIMedSchool #mRNA #transcription

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: PWWP mutants of the transcriptional cofactor JASPer divert promoter and enhancer activities and suppress position effect variegation in Drosophila By Atkinson et al., and Thomas Jenuwein ➡️ ow.ly/iuH050ZtCJa @DAtkinson_85 @mpi_ie

IN MEMORIAM: Greg Hannon: the scientist who changed biology, and the people who practiced it By Camila dos Santos ➡️ genesdev.cshlp.org/content/early/… @caoresco @CSHL

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: SMARCAL1 is a candidate therapeutic target for ALT-positive tumors By Taglialatela et al., and Alberto Ciccia ➡️ ow.ly/zIUT50ZoCce @CicciaAlberto @Columbia #cancer #telomere #cancertherapy

🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: TET1 noncatalytic activity shapes the chromatin landscape associated with de novo methylation establishment in the male germline By Prasasya et al., and Marisa Bartolomei ➡️ ow.ly/fLxF50ZoBLC @PennMedicine @Penn #epigenetics

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Coordination of nuclear RNA processing by speckle-localized kinase TAOK2 By Begg, Tracey et al., and Kristen Lynch ➡️ ow.ly/hkny50ZoBpT @PennMedicine @Penn #kinase #nuclearspeckle #RNA #RNAsplicing

🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: The Bcl11–Cxxc1 axis regulates stage-specific chromatin accessibility during lymphocyte development By Okuyama et al., and Ichiro Taniuchi ➡️ ow.ly/Kwpm50ZoxzW @riken_en #transcriptionfactor #lymphocyte #Tcell #Bcell #chromatin

ON THE COVER: MLL4 on the treadmill of chromatin, supporting the stamina of TGF-β signaling. Artwork by Maria De-Castro. Learn more in this study by Chan et al. and Marc Timmers: ➡️ genesdev.cshlp.org/content/40/13-… @timothykoala @UniFreiburg @DKFZ @mpi_ie

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: LKB1 functions as a checkpoint for neuronal–glial balance during enteric nervous system development By Lucas et al., and Chantal Thibert ➡️ ow.ly/3aOa50Zox1A @UGrenobleAlpes @Inserm #neurodevelopment #metabolism #glia #neuron #kinase

OUTLOOK: A new perspective on ATR's role in translesion synthesis By Laura Lindsey-Boltz and Aziz Sancar ➡️ genesdev.cshlp.org/content/40/13-… Also read: ➡️ genesdev.cshlp.org/content/40/13-… @AzizGwenSancar @UNC @UNC_SOM @UNC_BCBP #DNAreplication #DNArepair #genomestability #translesionsynthesis

RESEARCH PAPER: MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress By Cohn et al. and Rosalie Sears ➡️ genesdev.cshlp.org/content/40/13-… @OHSUNews #DNArepair #MYC #cancer #genomestability

RESEARCH PAPER: CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning By Liu et al. and Jeremy Reiter ➡️ genesdev.cshlp.org/content/40/13-… @UCSF @UCSFCancer @czbiohub #kinase #microtubule #heart #brain

RESEARCH PAPER: Evolutionarily conserved spliceosome–exosome pathway in nuclear mRNA surveillance By Abbas et al. and Elena Conti ➡️ genesdev.cshlp.org/content/40/13-… @MPI_Biochem #RNAdecay #splicing #mRNA #RNAsurveillance