Genes & Development

🚨 NEW ISSUE ALERT!!! 🚨 New Research articles online now at Genes & Development! Also in this issue, an Outlook on target-directed miRNA degradation, and a Review discussing the recent advances in optogenetics! Click here to learn more: ➡️ genesdev.cshlp.org/content/40/9-1…

RESEARCH COMMUNICATION: Nested pediatric low-grade glioma cerebral organoid avatars reveal glutamatergic neuron stromal growth dependency By Xu et al. and David Gutmann ➡️ genesdev.cshlp.org/content/40/9-1… @WUSTLnews @washumedicine #braincancer #stemcells #organoids

🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: DAXX directs dual modes of H3.4-to-H3.3 histone replacement in the male germline By Yeh et al. and Satoshi Namekawa ➡️ ow.ly/A8By50YTxa9 @ucdavis #histone #germline #epigeneticinheritence

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity By Hamm et al. and Stephen Tapscott ➡️ ow.ly/BrVO50YTwyl @fredhutch @UW #developmentaldisease

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: A lncRNA drives developmentally timed decay of all members of an essential microRNA family By Grimme et al., and Katherine McJunkin ➡️ ow.ly/Fl9H50YNI47 @NIDDKgov @JohnsHopkins @UFNews @UF #lncRNA #TDMD #microRNA

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Chromatin binding and N-terminal domains of DNMT3B1 confer specificity for developmentally regulated CpG island methylation By Yasmin, Nesterova, and Neil Brockdorff ➡️ ow.ly/YoBp50YNHwx @BrockdorffLab @Komal__Yasmin @BiochemOxford

Our new paper is out in Genes & Development! We found that a small domain in PRC2 — the SBD — isn't just structural scaffolding. It's a mechanical switch that powers the whole complex. Remove it, and cancers driven by EZH2 mutations stop growing. 🧵

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: α-Satellite RNA marks the perinucleolar compartment and represses ribosomal RNA expression in naive human embryonic stem cells By Mittal, Ataei and Miguel Ramalho-Santos ➡️ ow.ly/YUv950YNIOI @MRSantosLab @mizanlam @UofT #stemcell #RNA

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity By Patriotis et al., and the late David Allis ➡️ ow.ly/YqbP50YNGZu @ael2b @RockefellerUniv @epicypher #epigenetic #histone #polycomb #lymphoma

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistance By Wang et al., Jean Zhao and Thomas Roberts ➡️ ow.ly/kkg550YNEZR @harvardmed @DanaFarber #cancer #PTEN #immunotherapy

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination By Sanchirmaa Namjilsuren and Karen Arndt ➡️ ow.ly/9Z5L50YNzVq @PittBioSci @PittTweet #transcription

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Embryonic stem cell factors DPPA2/4 amplify active H3K4me3–H2AK119ub chromatin domains in non-small cell lung cancer By Seneviratne et al. and Melanie A. Eckersley-Maslin ➡️ ow.ly/hMVh50YNzyW @PeterMacCC #NSCLC #epigenetic #stemcell

Waves of regulation control an important developmental gene. ow.ly/RnHh50YLh2n Read the full story online now at #GenesDev: ➡️ ow.ly/z4r850YLh2q @MRC_LMS @MPI_MolGen

🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: Temporal loss of En1 during limb development causes distinct phenotypes By Ringel et al., Stefan Mundlos, and Lila Allou ➡️ ow.ly/Mmt150YLeZE @MRC_LMS @MPI_MolGen #development #patterning #enhancer #lncRNA

Are you a DNMT3 enthusiast wondering how they achieve specificity at CpG islands during development? &why is DNMT3B specifically required for methylation on the inactive X? Read our work from @BrockdorffLab, genesdev.cshlp.org/content/early/… 🧵 [1/13]

RESEARCH PAPER: Bypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage By Bañuelos et al. and Ramiro Verdun ➡️ genesdev.cshlp.org/content/40/7-8… @caropau86 @SylvesterCancer @umiamimedicine #chromatin #histone #epigenetics #cellstress #chemotherapy

🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: Nested pediatric low-grade glioma cerebral organoid avatars reveal glutamatergic neuron stromal growth dependency By Xu et al. and David H. Gutmann ➡️ ow.ly/CiOc50YLcgG @WUSTLnews @washumedicine #braincancer #organoids

OUTLOOK: It takes two to cleave: the logic of cluster assistance By Owen Sanborn and Daniel Cifuentes ➡️ genesdev.cshlp.org/content/40/7-8… Also read: ➡️ genesdev.cshlp.org/content/40/7-8…

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: The microprotein SMIM26 connects metabolite transporters of the outer and inner mitochondrial membranes and is essential for respiratory chain function By Heizler et al. and Gunter Meister ➡️ ow.ly/PeG050YLay9 #mitochondria #lncRNA

A new view of aging: How the immune system rewrites rapid aging. Read the new #genesdev paper, online now ahead of print: ➡️ ow.ly/lCC950YKyO3 ow.ly/pba050YKyO1