Vulpes Bio

I remember when TACOs would give us 7% swings in the market. Now we get like 0.35%

$WVE

@TweetAwayDK That said even efficacious antidepressants fail trials often due to pbo performance

@Vulpescap Ah, right. I read where you said there wasn’t any drug left on board at day 14, just didn’t connect that to what we see in the chart. Thanks

$PRTC too cheap at $400M FD IMO. UK-listed, low liquidity, doesn't look like anyone is paying attention. I think Seaport Tx's (PRTC owns 35% plus MSD royalties) MDD trial has a good chance to hit. I think brex/zuranolone works in MDD but $SAGE was flew too close to the sun with a 2wk PEP because that worked in PPD (but the MOA is a better fit for PPD). Seaport PEP at 6wks is the proper trial design. PRTC also owns a clinically validated IPF drug ready for Ph3 (chance to be best-in-class). SpinCo needs to raise. It's a free call option -- if they can't raise and this disappears, still cheap. PRTC also owns the dregs of the Cobenfy economics (2% royalty above $2B), probably worth $100-200M NPV. Full writeup here (do your own work)

@TweetAwayDK Doses only given til day 14, then thin efficacy dropped off at day 42. That's my point - SAGE should have dosed out to 6wks like Seaport is doing

@Vulpescap Appreciate the write-up. Chart seems to show zuranolone is no better than placebo at day 42; doesn't fit thesis that SPT-300 with similar efficacy but 6wk/42 day trial design will work. Pipeline generally feels "me-too", early stage, needs funding. Cobenfy is meh. Tough sell

@nikitabier Can't wait for @elonmusk to spam my feed with AI videos again

The full power of Grok on the algorithm launches next week. It will be the most important change we've done on X.

@Biohazard3737 Sheep, who is Bonnie Blue?

@MelvinRiskMgmt Take a trip down to sci-hub .ru

Is there anything worse than the fckin Lancet subjournals for getting access? Even of these real academic libraries don't even pay for this ass lol

@BiotechAutist @a_a_free do you have an opinion on where this trades +/- on PDUFA for tiv?

@Vulpescap @a_a_free They actually did. But they told rgnx the same thing. ir.regenxbio.com/news-releases/…

Sorry I waited for this moment to troll you :p because you clearly did some misses on this one and it was 70% that it's gonna be approved. Well done on the previous hits but you got lucky because those companies are already shitcos. DNLI is well managed company and they know what they are doing.