Mariela Cortés López

I'm happy to share that since January, I have started my lab at @HelmholtzMunich @CompHealthMuc & Hauner CCRC (LMU) 🎉 We aim to combine single-cell, long-reads, computational modeling, and functional genomics to understand RNA-driven regulation in pediatric diseases.

We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: beuschlab.org/join-us Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with others!

I am currently recruiting PhD students, both computational and experimental jobs.helmholtz-muenchen.de/qb2hm and jobs.helmholtz-muenchen.de/ut89o Feel free to reach out or share with anyone interested.

I'm happy to share that since January, I have started my lab at @HelmholtzMunich @CompHealthMuc & Hauner CCRC (LMU) 🎉 We aim to combine single-cell, long-reads, computational modeling, and functional genomics to understand RNA-driven regulation in pediatric diseases.

Huge shoutout and congrats to Chiara Evans (@pharmphreshsci) & Hanzhi Luo (@hanzhi_luo)! 🎉 Two @KharasLab oral presentations TODAY at #ASH25: 🕧 12:30 W224 —MSI2 arginine methylation HSC and therapy 🕒 3:15 W311 — Blood stem cells & nuclear speckles with SON Don’t miss them!

Today, postdoc leaders from across campus met to determine next steps for winning a fair contract. We voiced our support for countering @WeillCornell's arbitrary deadline with OUR OWN strike deadline to ensure they make real progress by the end of the month. Stay tuned!

#OnlineFirst In the Spotlight: RNA Splicing as a Therapeutic Vulnerability in Therapy-Refractory #MultipleMyeloma doi.org/10.1158/2643-3… A commentary to Therapy-Resistant Subpopulation in Myeloma doi.org/10.1158/2643-3…

Interested in learning how to be a good speaker and give effective talks? Season 2 of the NYC Postdoc Night Science Club begins October 15th. Join us NYC Postdocs for a 2hr workshop and maybe also a drink at a bar! Free registration (usually ~100 come): docs.google.com/forms/d/1dIIbJ…

Today hundreds of us came out to our Picket to Protect Science to show @WeillCornell that they must agree to a fair contract now!

Hi, we've made a new R package for APA analysis of long read RNA-Seq data. Works best on Oxford Nanopore direct RNA-Seq data. We call it APALORD. apalord.com

Delighted to have our preprint led by @lvchosen1 up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells biorxiv.org/content/10.110… 🧵 below ...

The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to disease? These and other questions we will tackle within the SMaHT Network, now described in @Nature nature.com/articles/s4158…

Sharing this op-ed we co-authored with other international postdocs, highlighting the struggle of doing science under an increasingly hostile political climate, while also fighting for fairer working conditions.

Very excited to share our new paper out now in @MolecularCell. We show how U1 snRNP -a well-known splicing factor- regulates the activity of alternative promoters in human cells cell.com/molecular-cell…

[1/n]📢How is your spatial analysis *transcript*-omic if transcripts are only aggregated to gene counts? Introducing SPLISOSM, our new computational method for learning the isoform landscape and its regulation from spatial transcriptomics data doi.org/10.1101/2025.0…

"Single-molecule multimodal timing of in vivo mRNA synthesis" a collaboration with Rippei Hayashi's lab, work led by AJ Sethi @_AJSethi #RNA #premRNA #splicing #RNAprocessing #m6A #polyadenylation biorxiv.org/content/10.110…

🚨Today in @CellCellPress, we show that RNA splicing factor mutations in myeloid cancers generate splicing-derived public neoantigens targetable by #TCR tx. Amazing collaboration co-led by @AbdelWahablab, @bradleybio, and @KlebanoffLab. #Tcellpower cell.com/cell/fulltext/…

Strike Authorization Vote is open!!! One year and not fair contract!!! Enough is enough!!

What happens when sequencing costs go ⏬ ? Imagination and new opportunities go ⏫ @landau_lab Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the @UltimaGenomics platform 🧵👇 Lets goooo!! rdcu.be/ehkUb

We are excited to share our new preprint on LeafCutter2! Our new method clusters, quantifies, and classifies splice junctions and intron clusters according to their molecular functionality (e.g., protein-coding or NMD-splicing). @yang_i_li doi.org/10.1101/2025.0…

Thrilled to share the first pre-print from our lab! We tackled a big question: Why are some pediatric leukemias extremely aggressive? We explored the developmental origins of fusion-driven acute myeloid leukemia (AML). Let's dive in! #AML #NUP98 n/13