Michael Kharas MSK

🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML. Amazing work by @lvchosen1 with @silvirouskin, @Armstrong_dfci, and many more! cell.com/cell/fulltext/…

Excited to announce a new paper out now in @CD_AACR on a unique CAR T cell platform that eliminates AML and B-ALL without harming vital endogenous immune cells or other normal human tissues: pubmed.ncbi.nlm.nih.gov/42059863/

@leonard_zon Congrats to George! It’s the dynamic duo! Always great to see you together! Cheers!

Congrats to my friend and colleague, George Daley, for his induction into the National Academy of Sciences.

@WSJ Amazing news! Congrats to Ross and Team!

Eli Lilly continued its recent buying spree, agreeing to pay up to $2.3 billion for Ajax Therapeutics in a deal that bolsters the drugmaker’s blood-cancer portfolio. on.wsj.com/4vSypnF

@Gritsman_lab @SteidlUli Congrats!!!!!

Congratulations @SteidlUli! So well deserved and great news for our cancer center and for Einstein!

@landau_lab @CD_AACR Congrats!

Woohoo! So proud to be featured on @CD_AACR cover!

@chartnote @leonard_zon Congrats!

@leonard_zon A well-deserved honor. Giving the March of Dimes Prize Lecture is an incredible recognition—celebrating a career of impact, mentorship, and discovery.

Very honored to give the Richard B. Johnston, Jr., MD March of Dimes Prize Lecture today at the SRI meeting in Puerto Rico. Emre Seli presented the award to me. Very appreciative to my lab and to my family.

@AbdelWahablab @natgenet @KellyLBolton @WashU @IrenaeusChan @PuZhang09980432 Congrats!!!

Excited to announce a paper out today in @natgenet.nature.com identifying an approach to mitigate the risk of therapy-related myeloid malignancies in patients with cancer. Collaboration with @KellyLBolton @WashU and led by @IrenaeusChan & @PuZhang09980432 nature.com/articles/s4158…

@iannisaifantis1 @landau_lab @nyugrossman Congrats! Always impressed with your leadership! Cheers!

After almost 13 years I am stepping down from the helm of the Department of Pathology @nyugrossman. It was a privilege and a pleasure to contribute to the creation of one of the most exciting Pathology Departments in the US and to work with fantastic colleagues, pathologists, research scientists, staff and trainees. During this exciting period, the department of Pathology almost tripled its faculty numbers, clinical and research (grant) revenue and invested heavily in a state-of-the-art molecular pathology lab, the growth of molecular microbiology, the expansion and automation of our clinical labs, and the integration of new digital and artificial intelligence tools that are redefining how our pathologists diagnose disease. We are now one of the few departments with ~100% slide digitization and a fully digital sign out. At the same time, the department’s research profile has increased significantly with the recruitment of leaders in the areas of immunology, cancer biology, computational science as well as world-renowned pathologists and physician-scientists. On a personal level, I was blessed to be thrown in deep water early in my life and bet on the talent and brilliance of colleagues who helped me set the foundation for a truly integrated and modern Pathology Department. I remain here to aid the transition of leadership, excited to spend more time in my own research laboratory and soon take up new challenges...@NYUGSOM_Path

@Dan_A_Heller Congrats!

On the cover of this month's issue of Nature Nanotechnology! Our nanosensor + AI-based liquid biopsy (blood test) for brain tumors that also enables the discovery of new biomarkers. nature.com/articles/s4156…

Hello everyone! We're participating in @Cycle4Survival to raise money for rare cancer research at @MSKCancerCenter, and your support would mean so much to us. Make a 100% tax-deductible donation using the link. Thank you! secure2.convio.net/mskcc/site/TR?…

Researchers @MSKCancerCenter @WeillCornell Discover PGBD5 Guides Normal Brain Development in Addition to Causing Cancers mskcc.org/news/researche…

@ScienceAdvances @KentsisResearch Congrats Alex!! Amazing to see this story out!! Love the cover!!!

Researchers identify PGBD5, a transposase-derived gene, as an essential regulator of normal brain development in mice and humans. Learn more in this week’s issue of Science Advances: scim.ag/4pGsjT8

@dstarczynowski @bloodgenes @GauravA_UK @ScienceMagazine @broadinstitute @hhmi_science @BostonChildrens @DanaFarberNews @DanaFarber Thanks!!

@bloodgenes @GauravA_UK @KharasLab @ScienceMagazine @broadinstitute @hhmi_science @BostonChildrens @DanaFarberNews @DanaFarber Congrats!! Awesome story!!

Delighted to have our work on 🧬 resilience to 🩸cancer led by @GauravA_UK & amazing collaborators, including @KharasLab, published in @ScienceMagazine: science.org/doi/10.1126/sc… 🧵

People with TP53 mutations have blood stem cell clones (CHIP) which promote chronic inflammation, aging, and risk of blood cancers. This can be blocked by multiple means (as shown below) to potentially prevent cancer, but CHIP is not assayed in the clinic. jci.org/articles/view/… @jclinicalinvest

Scientists have known for decades that there are gene mutations that increase your risk of developing cancer. But there is also a genetic variant that could reduce the risk of developing certain #bloodcancers, according to new research co-led by scientists from MSK. “We’ve discovered the mechanism by which a change within the MUSASHI2 (MSI2) gene region appears to protect people from blood cancers related to clonal hematopoiesis,” says cancer biologist @KharasLab, a member of the Molecular Pharmacology Program in the Sloan Kettering Institute and co-corresponding author of the paper.  Learn more: bit.ly/3N0Vxyt

@LeeGrimesLab @GauravA_UK @bloodgenes @_ruslansoldatov @AbdelWahablab @AlexBickMDPhD Thanks so much Lee!!!

@KharasLab @GauravA_UK @bloodgenes @_ruslansoldatov @AbdelWahablab @AlexBickMDPhD very cool. Congrats.

Check out our latest story science.org/doi/10.1126/sc…! Huge thanks to @GauravA_UK and the @bloodgenes lab for driving this work forward together with us. This was a great team effort with outstanding collaborators @_ruslansoldatov, @AbdelWahablab, and @AlexBickMDPhD.