Dr.Roberto Collazo-Maldonado

*HLA-DQ Antibodies: The Silent Cracker That Starts the Blast* *************************** ⚡HLA-DQ antibodies are the most common de novo DSA ⚡HLA-DQ DSA have the worst graft outcomes (ABMR, TG, graft loss) ⚡DQ mismatch carries the highest risk of sensitization (↑cPRA) ⚡ HLA-DQ has dual polymorphism (α + β chains) ⚡Can form multiple heterodimers (cis + trans pairing) ⚡ More heterodimers → more epitopes → higher immunogenicity ⚡ HLA-DQ shows low expression but high pathogenicity ⚡ Expression is delayed but sustained → chronic rejection ⚡ DQ antibodies activate Akt / S6 / IL-6 pathways ⚡ Current matching underestimates DQ risk ⚡ Eplet/pairing-based analysis > antigen matching #KKNephBytes #Immunology @arvindcanchi @DrAkshayaJ @drshyambansal @hardik4u24 @isn_india @priti899 @suhalikapath @JJayameena

Hydroxychloroquine use in pediatric IgA nephropathy link.springer.com/article/10.100… @ASPNeph @ESPN_Society

Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention thelancet.com/journals/lance…

Today is Match Day, when graduating medical students find out where they’ll be doing their residencies. It’s been the same for decades. At noon all around the country, 4th yr medical students open envelopes (no email or text) to learn where they’ll spend the next several years training. It’s a thrilling day.

Want to know my most important takeaways from the new 2026 Cholesterol Guidelines? Set to music, of course. @AHAScience @ACCinTouch @ASPCardio Clip here- Full song at the link- youtube.com/watch?v=DRO5kH…

@kamleshkhunti @EASDnews @ADA_DiabetesPro @AskDrShashank @docwas @escardio @ACCinTouch @DiabetesUK @rcgp @IntDiabetesFed SGLT2i can only work, if your kidneys are hyperfiltrating and they usually don`t at low BMI (unless in DM) read this: academic.oup.com/ndt/advance-ar… and this: academic.oup.com/ndt/article/40…

Happy Match Week and good luck to all #Match2026 participants! Tag us in your posts and photos so we can celebrate you! #MedEd #NRMP

The Roles of A Proliferation-Inducing Ligand (APRIL) and B-Cell Activating Factor (BAFF) in IgA Nephropathy bit.ly/4rzPtLO @DanaRizk1

ADA resources to "Keep Your Kidneys Healthy." Nice resource for DM/CKD patients and their families. diabetes.org/kidney-care

#NephMadness 2026: Animal House Region Teams: Dogs vs Cats Experts: Autumn Harris & @DrKeeksPhD Writers: Sarah Street & Susan DiGiovanni Execs: @KidneyWars & @Nephro_Sparks bit.ly/NM26Animals

NEW #NephMadness Commentary by Autumn Harris on the #AJKDBlog: Animal House – Cats, Kidneys, and the Art of Surviving on Almost No Water bit.ly/NM26Harris

Key updates to this guideline include: ➡️ The use of the American Heart Association PREVENT-ASCVD equations to guide primary-prevention and lipid-lowering therapy decisions. ➡️ Testing Lp(a) at least once in a lifetime and selective apolipoprotein B measurement to improve risk assessment and guide treatment ➡️ The return of LDL-C and non-high-density lipoprotein cholesterol treatment goals (with lower targets for higher-risk groups) ➡️ Expanded use of coronary artery calcium scoring to reclassify risk[ME1.1] ✍🏼 @rblument1 @tygluckman @RonBlankstein @PamelaBMorris @pnatarajanmd @AnnMarieNavar @SethShayMartin @APRN_CNS @nyulangone @DrMichaelShapir @kgradneyrd @eugeniagianos @virani_md @KellieMcLain1 @ijeomaheartdoc @SamiaMoraMD @DrHeatherJohn @dmljmd

🔥 Apixaban beats rivaroxaban with lower risks of clinically lower bleeding! 🩺 The nephrologist always knew this. The cardiologists, GI specialists and surgeons may need to adjust their practices! nejm.org/doi/full/10.10…

Nolan Ryan and Pudge Rodriguez, 1991. At the time, Pudge was 19 years old while Ryan was 44 years old. He led the league in K per 9 for the 12th time at 10.6.

San Juan, Puerto Rico 🇵🇷

@ISNkidneycare @kidneydoc101 An important Question- how many nephrons (from both kidneys) does a healthy normal individual Human lose every hour they grow older after age 30 years (answer -about one)

Today, we mark #WorldKidneyDay! This year is extra special as we celebrate the 20th anniversary of this global movement 🎉 The 2026 campaign #OurKidneysOurPlanet continues to focus on the prevention and early detection of kidney disease, while bringing planetary health into the conversation. 🎂 Share your WKD anniversary wishes with us: worldkidneyday.org/world-kidney-d… @ISNkidneycare @@ifkf_wka #WorldKidneyDay #OurKidneysOurPlanet #KidneyHealthForAll #WorldKidneyDay20Years

Proactive vs Reactive DDAVP: The Clamp Finally Faces an RCT Thank you Thai Air Force for doing the trials that need to be done! pbfluids.com/2026/03/proact…

Prepping the field for the final time in San Juan. It’s been a fantastic 10 days here and I’ll take back a ton of memories. The people of Puerto Rico are friendly, accommodating folks who love their baseball. Strongly recommend this as a vacation spot. Thanks for hosting!!!

Finerenone in People with CKD, Type 2 Diabetes, and History ... : Clinical Journal of the American Society of Nephrology journals.lww.com/cjasn/abstract…