David Ochoa

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David Ochoa

David Ochoa

@d0choa

Drug discovery | Computational Biology | Human Disease Genetics | ML | Cloud computing - @opentargets - @emblebi

Cambridge, England Beigetreten Kasım 2011
1.1K Folgt1.1K Follower
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David Ochoa
David Ochoa@d0choa·
Great chat with @patrick_j_short on finding new drug targets by leveraging human genetic information in a public-private partnership. Thanks to @sanogenetics
Sano Genetics@sanogenetics

Episode 112 of The Genetics Podcast is live! 🚀 This week, we sit down with @d0choa, Platform Coordinator @OpenTargets, to discuss how their platform is enabling game-changing collaboration between academic research & big pharma. Listen here 👇 pod.fo/e/204ce7

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Inigo Martincorena
Inigo Martincorena@imartincorena·
Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] rdcu.be/fdqbr
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David Ochoa
David Ochoa@d0choa·
Thank you to all our data providers, partners, and the @OpenTargets core team who make this possible. 🙏
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David Ochoa
David Ochoa@d0choa·
Other highlights: 🧬 ENCODE-rE2G scores now in L2G → 5% gain in selectivity 📊 710 new GWAS Catalog studies → 5,000+ new credible sets (incl. Rand et al., Nat Genet 2025) ⚡ ClickHouse migration complete → ~2x query speed ☁️ Platform data now on AWS Open Data Program
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David Ochoa
David Ochoa@d0choa·
The @OpenTargets Platform spring 🌼 release is out — and this one marks the beginning of something we've been building towards for a while.
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David Ochoa
David Ochoa@d0choa·
The @OpenTargets Platform Spring 🌼 release brings a step-change in how we address common disease genetics. We included the results of a large-scale analysis on GWAS and functional genomics studies to inform target selection further 🧬👩‍💻 blog.opentargets.org/a-step-change-…
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David Ochoa
David Ochoa@d0choa·
The team is working to bring the best possible data and features, and we will soon seek community feedback, so please reach out if you want to know more.
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David Ochoa
David Ochoa@d0choa·
We have been working hard to blend the best of Open Targets Platform and Open Targets Genetics into a single product that will unify our thinking about genetically informed target identification.
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David Ochoa
David Ochoa@d0choa·
The Open Targets Platform autumn release 🍁 is full of new data and UI features. This is the last update before we make a giant leap forward in our common genetic evidence 🧬
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Dimitrios Vitsios
Dimitrios Vitsios@dimvitsios·
It was a pleasure visiting @OpenTargets and @ChEMBL, to present some of our recent #ML work and have such insightful discussions with @EllieMcDonagh, @d0choa and the rest of the teams! #MILTON Nat Gen: nature.com/articles/s4158… #MantisML 2.0 Sci Adv: science.org/doi/10.1126/sc…
Open Targets@OpenTargets

How can we apply AI/ML in drug target discovery? @dimvitsios and @ArwaRaies visited Open Targets last week to discuss this question, and present MILTON, an ML framework for multiomics and biomarker-based disease prediction Thank you to all attendees and roundtable participants!

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Open Targets
Open Targets@OpenTargets·
Join the Club! 🤝 A new study characterises types of Open Science Partnerships, featuring Open Targets as an example of “The Club” This research suggests how OSPs can best be designed for their goals, and provides a framework to understand their impact nature.com/articles/s4159…
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Open Targets
Open Targets@OpenTargets·
☀🌳 Summer walks through the Campus grounds Photo credit: Helena Cornu @wellcomegenome
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@OpenTargets @AnthropicAI @NatureGenet @AlbertHerms @Sangerinstitute @MariaPAlcolea @dimvitsios @ChEMBL