Dan Lewis

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Dan Lewis

Dan Lewis

@daniellewis

Exploring how we get things done with AI. CVP @ Microsoft for AI agents building platforms Copilot Studio and M365.

Seattle Beigetreten Nisan 2009
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Chris Hladczuk
Chris Hladczuk@chrishlad·
We raised a $27M Series A to replace the spreadsheets and human duct tape behind $100 trillion in global assets. Fund administration is the invisible backbone of private equity and venture capital - and it’s broken. Why? Financial data is scattered, stale, and locked inside legacy providers. Books take forever to close. Basic questions about your own fund take days to answer. So we rebuilt the general ledger, waterfall engine, investor portal, and portfolio management from scratch. One single source of truth for your firm. Our AI agents read emails, propose journal entries, and extract portfolio updates in seconds. Our CPAs review every output. Today, we administer $15 billion in assets - and we’re just getting started. Every fund CFO keeps getting asked: how will you adopt AI? Now you have an answer. Run your firm in real-time with @hanoverpark. –- Excited to partner with Jake Saper at @emergencecap @peterjhebert at Lux, @chadbyers/@pratyushbuddiga at Susa and CFOs at the largest private equity firms to forge this future.
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Michael Magán
Michael Magán@mrmagan_·
generative user interfaces at the speed of thought. you can now build "tab autocomplete" for every app. ultra-fast inference @cerebras & your components render by the @tambo_ai agent.
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Aakash Gupta
Aakash Gupta@aakashgupta·
The math on this project should mass-humble every AI lab on the planet. 1 cubic millimeter. One-millionth of a human brain. Harvard and Google spent 10 years mapping it. The imaging alone took 326 days. They sliced the tissue into 5,000 wafers each 30 nanometers thick, ran them through a $6 million electron microscope, then needed Google’s ML models to stitch the 3D reconstruction because no human team could process the output. The result: 57,000 cells, 150 million synapses, 230 millimeters of blood vessels, compressed into 1.4 petabytes of raw data. For context, 1.4 petabytes is roughly 1.4 million gigabytes. From a speck smaller than a grain of rice. Now scale that. The full human brain is one million times larger. Mapping the whole thing at this resolution would produce approximately 1.4 zettabytes of data. That’s roughly equal to all the data generated on Earth in a single year. The storage alone would cost an estimated $50 billion and require a 140-acre data center, which would make it the largest on the planet. And they found things textbooks don’t contain. One neuron had over 5,000 connection points. Some axons had coiled themselves into tight whorls for completely unknown reasons. Pairs of cell clusters grew in mirror images of each other. Jeff Lichtman, the Harvard lead, said there’s “a chasm between what we already know and what we need to know.” This is why the next step isn’t a human brain. It’s a mouse hippocampus, 10 cubic millimeters, over the next five years. Because even a mouse brain is 1,000x larger than what they just mapped, and the full mouse connectome is the proof of concept before anyone attempts the human one. We’re building AI systems that loosely mimic neural networks while still unable to fully read the wiring diagram of a single cubic millimeter of the thing we’re trying to imitate. The original is 1.4 petabytes per millionth of its volume. Every AI model on Earth fits in a fraction of that. The brain runs on 20 watts and fits in your skull. The data center required to merely describe one-millionth of it would span 140 acres.
All day Astronomy@forallcurious

🚨: Scientists mapped 1 mm³ of a human brain ─ less than a grain of rice ─ and a microscopic cosmos appeared.

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Brendan (can/do)
Brendan (can/do)@BrendanFoody·
Gemini 3.1 Pro is now at the top of the APEX-Agents leaderboard. Gemini jumped from 18.4% to 33.5% on Pass@1 in just 90 days. It also completes 5 tasks that no model has ever been able to do before. @GeminiApp shows how quickly agents are improving at real knowledge work. It can turn hundreds of documents, spreadsheets, and emails in Google Workspace into a client-ready deliverable. This rapid progress is evidence that we will be able to saturate any benchmark. The bottleneck is measuring all economic value.
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Michael Magán
Michael Magán@mrmagan_·
your app's UI has entered the chat. just register your UI components and your APIs. build an agent that speaks your interface in minutes 👇
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Martyupnorth®- Unacceptable Fact Checker
A cool demonstration of physics. The truck is moving forward at 80 km/h. The guy is catapulted in the opposite direction at 80 km/hr.
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Apoorva Mehta
Apoorva Mehta@apoorva_mehta·
if you are thinking about joining a team, ask them for their ai token usage graph. if it's not exponential, reconsider.
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Michael Magán
Michael Magán@mrmagan_·
build an agent that speaks your UI. your charts. your forms. your seat maps. multi-turn, streaming, interactive. introducing tambo 1.0, the open-source generative UI toolkit for react.
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Dan Lewis@daniellewis·
Someday, we'll look back on these chats fondly lol
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Dan Lewis@daniellewis·
Solves the "but will it work for my business?" problem. One of the best teams out there. Congrats @ypatil125, @rhythmrg, and @lindensli !
Applied Compute@appliedcompute

Generalists are useful, but it’s not enough to be smart. Advances come from specialists, whether human or machine. To have an edge, agents need specific expertise, within specific companies, built on models trained on specific data. We call this Specific Intelligence. It's what we're building at Applied Compute. We unlock the latent knowledge inside a company, use it to train custom models, and deploy an in-house agent workforce that reports to your team. We work with sophisticated companies that have already captured early gains from general models, like @cognition, @DoorDash, and @mercor_ai. They’re pulling even further ahead with proprietary in-house agents that don’t need to wait for the next public model release. Together, we are building and validating models and agents in days instead of months, achieving state-of-the-art performance on customer evals. Our team has high density and low latency. Our founders all worked on different parts of this problem while they were researchers at OpenAI — @ypatil125 as a key member on the agentic software engineer effort (Codex), @rhythmrg as a core contributor to the first RL-trained reasoning model (o1), and @lindensli as a core contributor on ML systems and infrastructure for RL training. Two-thirds of the team are former founders, and everyone brings a deep technical background, from top AI researchers to Math Olympiad winners. We are backed by $80M in funding from Benchmark, Sequoia, Lux, Elad Gil, Victor Lazarte, Omri Casspi, and others. With their support, we are growing the team, scaling deployments, and bringing to market the first generation of agent workforces built on specific models. In short: 1. We are building Specific Intelligence for specific work at specific companies. 2. That will power in-house agent workforces to support their human bosses. 3. That in turn will unlock AI’s full potential through humanity’s greatest engine of progress: thriving corporations in a free market.

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Brendan (can/do)
Brendan (can/do)@BrendanFoody·
We’ve raised our $350M Series C at a $10B valuation from @felicis, @benchmark, and @generalcatalyst. Just 2 years after starting, Mercor is paying $1.5 million per day to experts in our marketplace. We’re creating a new category of work in the AI economy, where software engineers, bankers, lawyers, and other professionals earn based on their experience while advancing the frontier of AI. While most new categories take time to build momentum, we’ve broken every growth record. For comparison, in their first 2 years: - Uber paid out just over a $1 million to drivers - Airbnb paid out $10 million to hosts We are unlocking human potential in the AI economy.
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Satya Nadella
Satya Nadella@satyanadella·
Today we’re expanding Microsoft 365 Copilot with the addition of Anthropic’s Claude models. Customers can now use both OpenAI and Claude — starting in Researcher and Copilot Studio, and coming to more experiences soon. Our multi-model approach goes beyond choice. It's all about bringing the best AI from across the industry to Copilot, tuned for work and tailored to every business. Read more: microsoft.com/en-us/microsof…
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Dan Lewis@daniellewis·
@saranormous Code names (both word and picture versions)
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sarah guo@saranormous·
newish fun board games that don’t take a huge amount of time to learn to play, and can be finished in 2H?
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Aaron Levie
Aaron Levie@levie·
Grok 4 looks very strong. Importantly, it has a mode where multiple agents go do the same task in parallel, then compare their work and figure out the best answer. In the future, the amount of intelligence you get will just be based on how much compute you throw at it.
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Michael Magán
Michael Magán@mrmagan_·
we just talked to hundreds of people building with ai across: - fintech - edtech - b2b saas - web3 - dev tools - healthtech - hrtech - legaltech 80%+ were building ai assistants. 50% of them had already built some form of generative ui into their assistants. most weren’t happy with what they built — and many were excited to see how we had solved those problems (and more). the other half hadn’t built it yet, but were pumped by how simple we made it to get started. we are accelerating the future of gen UI. thanks @michael_milst, @heyavi_, @alecf for giving back to back demos for hours straight :)
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Aaron Levie
Aaron Levie@levie·
The real AI unlock was realizing we could give AI Agents access to all the tools and data relevant to particular work. The main thing that matters then is having models be insanely good at reasoning and many general skills, and then add the right context at inference time.
vitrupo@vitrupo

Sam Altman says the perfect AI is “a very tiny model with superhuman reasoning, 1 trillion tokens of context, and access to every tool you can imagine.” It doesn't need to contain the knowledge - just the ability to think, search, simulate, and solve anything.

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