Justin Machine

Linoleic acid (the primary fat in seed oils) has multiple fates, with a primary outcome being the production of 4-HNE. This paper (linked below) reinforces the evidence that 4-HNE contributes to metabolic problems, including #insulinresistance, by limiting the ability of subcutaneous fat to proliferate (i.e., make more fat cells; "hyperplasia"). This may seem like a good thing, but by limiting hyperplasia, any pressure for the fat cells to grow must now lead only to hypertrophy (i.e., growth of the cell). Hypertrophic fat cells undergo two important adaptations: 1. They become insulin resistant to prevent further growth (after all, insulin is the primary growth signal on fat cells); 2. They become inflammatory in an effort to increase blood flow to prevent hypoxia ("suffocation of the cell"). These two adaptations, both of which are intended to help the hypertrophic fat cells survive, end up spreading insulin resistance throughout the body. Back to the study: The authors find that even modest elevations in 4-HNE are sufficient to cause these changes. As much as I'm an advocate of eating fat liberally, focus on natural fats: animal fats and fruit fats (e.g., olive, coconut, etc.). pubmed.ncbi.nlm.nih.gov/38068967/

@paulsaladinomd If you’re concerned about fertility it seems that the logical first step is getting a spouse!?

This may sound crazy but… Your underwear could be decreasing fertility! Check out this study…

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@_CynthiaThurlow Substitute with allulose.

Last week, we chatted with Dr. Bikman about the implications of using GLP-1 medications for weight loss. Where do you currently stand on the topic?

There’s no such thing as a food company! Nature makes food. Companies make products.

Obviously the bottom 2/3rds must therefore be prevented from eating... "World's richest 1% emit as much carbon as bottom two-thirds: report" phys.org/news/2023-11-w…

Oh, rats? One 300-gram rat contains 648 Calories, 63 g of protein, and 33 grams of fat. The same amount of actual lamb shoulder provides just 402 Calories and 61 grams of protein, and just 16 grams fat. 300 grams of New York Sirloin would get you 684 Cal, 62g protein, 47g fat).

If nutrition researchers ever got their stuff in order the fitness industry wouldn’t exist.

"Hyperinsulinemia can directly induce pancreatic cancer initiation from acinar cells" cc' @BenBikmanPhD @Sam_Apple1 cell.com/cell-metabolis…

Three things to improve yourself: Be content Be compassionate Be carnivore

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The first gym in America didn’t open until 1936. I guess everyone was “out of shape” before then. Diet is everything!

Seed oils break metabolic machinery and sugar breaks metabolism hormones. The 1 - 2 punch of processed foods.

It’s not the DNA that changed it’s the diet!!👇 “The Ancestral Diet Revolution” - Chris Knobbe

‼️New observational research indicates that reading Harvard nutrition studies increases your risk for type 2 diabetes.‼️

If you live for pleasure you’ll die in pain.

Universal nutrition advice for everyone: - Added sugar and refined grains cause harm. - Seed oils cause harm. - Vegetables MAY cause harm so know yourself and how to prepare them. - An overwhelmed Randell cycle leads to systemic metabolic dysfunction.

A contradictory statement in the diet health space. “Evolutionary designed” Nope, sorry can’t have it both ways.

Can someone please explain to me what a healthy grain is!?

Can you get every nutrient you need in the proportion you need them in your diet without modern technology? If no, then your diet is deficient. If yes, march on!