Effi Kenigsberg

322 posts

Effi Kenigsberg

Effi Kenigsberg

@effiken

Principal Computational Scientist at Genentech. My own opinions

Manhattan, NY Beigetreten Mayıs 2013
607 Folgt430 Follower
Effi Kenigsberg retweetet
Barak Raveh
Barak Raveh@BarakRaveh·
Presenting DeepDynamics, a joint effort by the @naomi_habib and @BarakRaveh Labs. We have built a deep learning framework that bridges bulk and single-cell RNA-seq to map the cellular cascades underlying Alzheimer’s Disease (AD) and aging. #alzheimer #deeplearning #ROSMAP 1/10
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Arjun Raj
Arjun Raj@arjunrajlab·
Check out this great new print from @yael_heyman on spatial transcriptomics and intestinal zonation! I particularly love her “transplant” experiments, showing that cells transplanted to a new location adopt the local zonation pattern!
Yael Heyman@yael_heyman

Excited to share our new work on self-organized zonation in the intestine! Enterocytes have location-dependent functions along the crypt-villus axis. How do cells "know" their position? Three possibilities: external signals, internal programs, or local cell communication. 1/6

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Leeat Keren
Leeat Keren@leeat_keren·
Excited to see this out: A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology science.org/doi/10.1126/sc…
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Akhiad
Akhiad@Akhiad6·
Do we need LLMs to predict epigenomes from DNA—or is biophysics enough? 🧬 IceQream (IQ) is a biophysics-based framework that predicts epigenomes with SOTA-level accuracy—and is fully explainable. @NatureComms: nature.com/articles/s4146… Thread 🧵👇 1/
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Xavier Lab
Xavier Lab@TheXavierLab·
Check out our recent work with John Rioux and the iGenoMed Consortium! Serum proteomic and metabolomic profiling in #IBD patients initiating vedolizumab identified pro-inflammatory analytes associated with treatment response. onlinelibrary.wiley.com/doi/10.1111/im…
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Xavier Lab
Xavier Lab@TheXavierLab·
Very excited to share our latest work in @NatureGenet w/ @cssmillie’s lab: a spatial transcriptomics atlas of stricturing #Crohns disease that offers new insights into mechanisms driving fibrotic complications in chronic gut inflammation...(cont.) nature.com/articles/s4158…
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Amir Giladi
Amir Giladi@AmirGiladi·
We are excited to share our new research article, in which we, for the first time, identified a human intestinal reserve stem cell, namely tuft cells, by combining novel organoid models and single-cell genomics (link: nature.com/articles/s4158…).
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Leeat Keren
Leeat Keren@leeat_keren·
Preprint alert! A spatial atlas of human gastro-intestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology biorxiv.org/cgi/content/sh…. We examined how immune cells are organized in the gut and what happens to them in GVHD. TL;DR Timing is key!
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Noam Kaplan
Noam Kaplan@Noam_Kaplan·
The radial positioning of genomic loci, i.e. how far they are from the nuclear lamina has been associated with genome structure and function for several decades. But in genomics everything is correlated, e.g. radial positioning with genomic compartments with gene activity etc
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shalev itzkovitz
shalev itzkovitz@SItzkovitz·
Happy to share our new paper: A spatial expression atlas of the adult human proximal small intestine, out today in @Nature: nature.com/articles/s4158…. We describe the zonated expression patterns of cells along and across the villus axis in the healthy adult small intestine.
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Entdecken

@naomi_habib @BarakRaveh @yael_heyman @CellCellPress @MVLocquenghien @PascaleZwicky @CuriousKX @NatureComms