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Rohan
1.9K posts
@Yash25571056 Do you think this is the underlying cause of chronic fatigue in Long COVID?
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"[In this study,] We demonstrate that SARS-CoV-2 E(small transmembrane envelope) protein localizes to host cell mitochondria and alters mitochondrial structure, metabolism, and redox homeostasis..
Mitochondrial membrane potential was decreased in E-expressing cells, consistent with disrupted electron transport chain (ETC) activity..
these findings suggest that E protein localizes to the mitochondria, perturbs lipid and metabolic homeostasis, and promotes ROS retention without inducing cell death."
SARS-CoV-2 is like a cluster bomb.
'SARS-CoV-2 envelope protein mitochondrial localization reveals host metabolic disruption'
sciencedirect.com/science/articl…
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If anyone is working with large datasets that might be relevant here, please reach out to @longcovidlabs - we'd love to help support this research.
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Again and again we see viruses linked to dementia and neurodegenerative disorders. This new study (n>160,000) showed high dose flu vaccines reduces Alzheimer's dementia.
Eric Topol@EricTopol
We've seen the Shingles vaccine is linked with reduced risk of Alzheimer's and dementias in 4 large natural experiments. Today, the potential of high-dose flu vaccines vs standard dose for the same in a large retrospective age 65+ cohort [N>160,000). More pronounced in women (like Shingles vaccine) neurology.org/doi/pdf/10.121…
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Rohan retweetet
Lots of clinical trials for Long COVID coming out. Here's a quick guide on how to assess it.
A study is getting quite a bit of coverage, suggesting that the antidepressant fluvaxamine is effective for Long COVID. We'll use it as an example.
acpjournals.org/doi/10.7326/AN…
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@PhotonTurtle If viral persistence is root cause, I imagine this like other vagus interventions are just treating symptoms. Hope you're hanging in there.
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@rd108 Tried glp-1 for months, really did nothing for my severe case unfortunately. May try it again at higher dose if the trials come back positive.
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Fascinating. May explain the micro-dosing GLP-1 protocols for Long COVID - we know there is significant dysautonomia and vagus nerve dysfunction.
Prof. Kevin J. Tracey, MD@KevinJTraceyMD
Ozempic and GLP-1 cause weight loss via the vagus nerve. In people whose vagus nerve was surgically cut (below the diaphragm, not in the neck), GLP-1 did not reduce food intake or accelerate metabolism. These drugs work through the vagus, in ways we still do not fully understand.
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@sama @tyler_m_john Complete non-answer. Pathetic @sama. Here's the real answer: "I will do almost anything for money. I do not believe the consequences of my actions will have negative impact on me."
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I'd like to answer questions about our work with the DoW and our thinking over the past few days. Please AMA.
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One of those "hand-washing reduces infections" paradigm shifts - the role of viruses in accelerating aging is still not fully acknowledged.
I predict COVID-19 will, unfortunately, be a prime catalyst for this.
David Sinclair@davidasinclair
During their lives, centenarians rarely get sick. New paper with 1,400 subjects finds a history of infections (pneumonia, herpes, UTIs) associates with earlier frailty. The authors speculate that obesity makes people more susceptible & that viral infections may accelerate aging
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@imyouralfred tell @mattmedved to call me. he never calls. then cd ~/ && rm -rf . (just kidding, don't do that)
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Rohan retweetet
National Taiwan University researchers analyzed data from over 97 million individuals and found that COVID-19 is linked to a 49% higher risk of developing autoimmune diseases.
The risk rose after severe infection but dropped by 44% in vaccinated people.
link.springer.com/article/10.100…
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Rohan retweetet
A new RECOVER study of 6.4M health records shows Long COVID risk has not decreased from 2020–2024. Incidence stayed stable across variants, reinforcing Long COVID as an ongoing public health priority.
Read the study: doi.org/10.1093/cid/ci…
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3 years after antivirals and monoclonal antibodies cured my long COVID symptoms. Science can feel painfully slow. But hats off to the scientists, doctors and companies pushing the rock up the hill.
We need a global Moonshot for Long COVID, now.
plague ralph 🐀 (capo)@x3r0gx4
New cases series: @Invivyd's Pemgarda (Pemivibart) monoclonal antibodies shown to reduce PEM in three heterogenous Long COVID cases Is this the first evidence published in a scientific journal of COVID-specific mAbs treating PEM in Long COVID?
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Cool to see progress of two treatments.
1. Low dose rapamycin
2. Val/Cel
Can you tell when I started taking each?
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Rohan retweetet
Urine tells the story of #LongCOVID:
➡️ New study identifies a molecular fingerprint for #LongCOVID (PASC) — using just a urine test.
➡️ Researchers found 195 urinary peptides that can accurately distinguish Long COVID patients from healthy and ME/CFS controls (AUC > 0.95). 1/
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