Carter Brzezinski

Check out @HJLChem and I’s recent report on using VHPO enzymes to prepare oxindoles and spiro-oxindoles! Excited to see this work out and help eliminate the need for hazardous halogenating reagents and harsh oxidants. Go team VHPO!

@Braden_Keith @kylesockwell Gotcha ok. I live like 20 min from GT and want to take my gf to see a session so if you happen to hear about two tickets for Saturday I’d take you up on it!

@sp3intermediate @kylesockwell You can usually buy them on walk-up if there are any left. GT is big so there should be some left. Also work your connections - there's always teams and people with extra tickets. Will let you know if I hear of any.

@Braden_Keith is there no option to buy single-session tickets for NCAAs in ATL??? Is this usually the case??? Would kill to see a session or two but not for $180… cc @kylesockwell

Very honored to have our VHPO-catalyzed oxidative rearrangement of indoles highlighted in OPRD! Thanks so much, John and team! pubs.acs.org/doi/10.1021/ac…

After treatment @emoryhealthcare, 19-year-old Andrew Miles is the second person in the U.S. to live outside a hospital with a total artificial heart. The teenager was born with a heart defect that led to untreatable heart failure. 🔗 Full story: links.emory.edu/1oa

Formate chemistry ❤️ Amazing work!!

Divergent Asymmetric #Synthesis of Four Pentacyclic Homoproaporphine Alkaloids via C–H Elaboration by Liuyang Pu, Zhenbao Wang, JinYu Xia, Zhihong Chen, Miao Xiao, Lei Zhu, Jun Huang in @J_A_C_S pubs.acs.org/doi/10.1021/ja…

@Sculpturatus 100%. This quote from a nature paper write up drove me insane…

“AI” means a hundred different things. In drug discovery, it already works for ADME, PK/PD, and molecule optimization — and that’s real progress. But most failures come from target biology, not chemistry. To bend clinical success, AI must move from optimization to causality.

1 more week til our priority date for this 2-year VAP position in Chemistry at Kenyon College. A great opportunity to teach great students in a great place with great people! linkedin.com/jobs/view/4367…

@ndchiappini *VHPO cc @KFBChem

Roses are red, violets are blue. Catalase goes after H2O2

@Sculpturatus @PaulAustin3w lol

@PaulAustin3w what exactly is the y axis measuring here

Most people think the psychedelic experience is what heals. They're wrong. It's what happens in the days and weeks AFTER that determines everything. In 2023, Gül Dölen's lab at Johns Hopkins made a discovery that should reshape how every practitioner thinks about their work: MDMA, psilocybin, LSD, ketamine, and ibogaine all reopen the social reward learning critical period, those rare developmental windows when we learn how to bond, trust, and adapt. Our brains were once thought to close these windows by age 26. Turns out, psychedelics hand us the key to unlock them again. Here's what makes this research so compelling: Different compounds hit different receptors — 5-HT2A, NMDA, KOR — yet they converge on the same outcome: reopening critical learning windows. It's not the trip that heals. It's the open state. And each substance opens that window for a different duration: → Ketamine ≈ 48 hours → Psilocybin ≈ 2 weeks → LSD ≈ 3 weeks → Ibogaine/5-MeO-DMT ≈ 4 weeks This isn't chaotic hyperplasticity. It's metaplasticity, a refined readiness to rewire. Dölen's team found oxytocin-mediated changes in the nucleus accumbens and softened extracellular matrix, which basically means the brain's scaffolding loosens so new wiring can stabilize. Think of it as a biological permission slip for transformation. But here's what most people miss: this window is time-sensitive. During the open state, new behavioral habits and secure attachment patterns can take root. Miss the window, and old circuitry reasserts itself. Most people don't realize how critical the days and weeks AFTER a session really are. This is exactly why we built our Practitioner Training at the Psychedelic Coaching Institute the way we did. If the medicine opens a window, then the practitioner's job is to help clients make the most of it before it closes. That means designing protocols around windows, not just sessions. It means mapping dose → duration → practice. Tracking behavior, HRV, mood, and relational change weekly. The aim isn't to chase peak experiences. It's to facilitate durable rewiring through intentional repetition in the open state. This is the next era of psychedelic work: utilizing microdosing, nervous system training, and intentional practice to expand the learning window. The medicine opens it. Your discipline keeps it open. That's how insight becomes identity. For practitioners ready to work at this level, our next PCI cohort (kicking off February 19!) is where this science meets real-world application. What are your thoughts on how to design integration around the critical period window?

Excited to share that my postdoc work has now been published in PNAS. In this study, we demonstrate how flavin-dependent enzymes can be leveraged to generate and control radicals, enabling selective C(sp³)–C(sp³) bond formation. pnas.org/doi/10.1073/pn…

@ndchiappini 10000% agree. The number of students I see using chat gpt to solve their lab problems is embarrassing, genuinely makes me sad.

AI "art", scientific graphics, figures are extreme loser shit. Take an active role in the act of creation. The results of this stuff look like refried dogshit anyway. Don't know how to make a figure? Ask peers! Learn by example! Experiment! That's you improve.

David B. C. Martin先生。ハロゲン化鉄(III)のハロゲンの違いによって光触媒特性が変わるという論文。 #学ぶの論文紹介 Ligand-Enabled Photocatalytic Reactivity of Iron(III) Halide Salts with Cyan and Green Light | Organic Letters pubs.acs.org/doi/10.1021/ac…

Enantioselective Beckmann Rearrangement through Organocatalytic Desymmetrization of Cyclobutanones for the Synthesis of 4,4-Disubstituted γ-Lactams | Organic Letters pubs.acs.org/doi/10.1021/ac… 👏👏Congrats Antón and the rest of the team!👏👏

Organicatalytic Birch-type reductions of electron-rich arenes under mild conditions enabled by light irradiation💡. Our latest work is now published in JACS. ✨ pubs.acs.org/doi/10.1021/ja…

16-Step Scalable #ChemoenzymaticSynthesis of Tetrodotoxin by Chen Peng, Weilin Wu, @YuxuanYe2 and @PengfeiHu2 at @Westlake_Uni in @J_A_C_S pubs.acs.org/doi/10.1021/ja…

Wow!!! Allostery ftw

KFB Lab Alert: Our general biocatalytic platform for oxidative rearrangement of indoles is now online @ACSCatalysis! Congratulations to @HJLChem on leading this effort alongside an excellent team of @sp3intermediate, Raina, Ana, Sophie, and John! pubs.acs.org/doi/10.1021/ac…

Catalytic Enantioselective Synthesis of 1,1-Disubstituted Isochromans | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…