Carter Brzezinski

Check out @HJLChem and I’s recent report on using VHPO enzymes to prepare oxindoles and spiro-oxindoles! Excited to see this work out and help eliminate the need for hazardous halogenating reagents and harsh oxidants. Go team VHPO!

Check out our ChemRxiv preprint on direct amine umpolung: a one-step conversion of primary amines into versatile electrophilic aminating agents using MPO, enabling amination, complex fragment coupling and chiral hydrazine synthesis. Congrats to the team! chemrxiv.org/doi/abs/10.264…

Delighted to see this one now out in @ACSCatalysis. Congrats to Paul for spearheading this tour de force of a project and to everyone involved! A practical approach to ambient arene hydrogenation. pubs.acs.org/doi/10.1021/ac…

#TotalSynthesis of Indigotinoline A and Enabled Stereochemical Revision of Isatindigotindoline B by Jiaji Li, Zhibin Zhao, Peiyuan Yang, Mingquan Wang, Sen Zhang, Tianyu Lv, Lianjie Zhang, Lu Yang, Shaojiang Song, Xiaoxiao Huang, Yongxiang Liu in @JOC_OL pubs.acs.org/doi/10.1021/ac…

Sp3 Methylene CH coupling with heteroaryls has been limited (really annoying for medichemists). With bifunctional pyridone ligands and new mechanism via Pd(II)/Pd(0), we made a big stride: doi.org/10.26434/chemr…

Check out our recent work on a systemic analysis of N-heterocycle halogenation with our favorite chloroperoxidase! Big thanks to Sergio, Hannah, and @jbacsa1 for the help! Got a tricky halogenation with poor selectivity or yield? Please let us know, we’d love to give it a try!

KFB Lab Alert: One Biocatalyst, LOTS of N-Heterocycle Halogenations! Our latest work on the development of an efficient screening workflow for VHPO halogenation is now online @ChemRxiv. Huge congratulations to @sp3intermediate for leading this work with an awesome team of Sergio, @HannahSlocumb5, and @jbacsa1! #Haloplates chemrxiv.org/doi/full/10.26…

KFB Lab Alert: Our report on the Newman-Kwart Rearrangement enabled by Flavin Photoredox is now available @ACSCatalysis! A very efficient system for the transformation! Huge congratulations to @CG_Chem and @ManiksharmaASR for leading this work! pubs.acs.org/doi/10.1021/ac…

Chirally dense noncanonical prolines synthesized via a TrpB-IRED cascade, now out in ACS Catalysis! Congratulations to Wenxuan Li and Noah Hamlish for driving the project, and Richard Ayikpoe for collaborating on vision! pubs.acs.org/doi/10.1021/ac… pubs.acs.org/doi/10.1021/ac…

Check out our latest work on the co-catalytic reductive cross coupling of aryl bromides and alkynes through the merger of ZrH and Pd catalysis: pubs.acs.org/doi/10.1021/ac… Kudos to the team: Marymoud Erzuah, @raj_abhishekk_ @RebeccaKehner

Couldn’t agree more!

Pleased to share our @J_A_C_S paper on de novo pyrrole synthesis using O-vinylhydroxylamines. These reagents are versatile annulation partners for rapid, regioselective access to electron-deficient and highly substituted pyrroles under mild conditions. pubs.acs.org/doi/10.1021/ja…

Recently, Ben and Allison published a procedure for the enzymatic saponification of esters containing β-leaving groups in @OrgSynth. Many thanks to Kevin Campos and the team @Merck for checking, and congrats to the authors! Read it here: orgsyn.org/demo.aspx?prep… @uclachem

The incorporation of enzymatic reactions in natural product total synthesis in the past few years is so awesome and inspiring - I really feel like this has ramped up recently. Enzymes are great for everyone, not just process chemists!

@LabChao Amazing work, love the epoxide hydrolase step!!!

Our latest work shows how modern total synthesis can enable therapeutically meaningful discovery, uncovering selective anti-C. difficile activity and toxin-protective effects of structurally complex polyether ionophores. Now available on ChemRxiv: chemrxiv.org/doi/full/10.26…

@Braden_Keith It’s juicy, but “the absolutely juciest newsbit that swimming has had in quite some time”?

Boooo I’m annoyed by nobody being as excited about this as I am. The internet has messed up all y’all’s chemicals lol.

Our @J_A_C_S paper is out! We found a unique PLP enzyme that builds α-hydroxy β-amino acids. Can’t wait to make more and more strange amino acids with this guy! pubs.acs.org/doi/10.1021/ja…

Today in ChemRxiv, we report the C-H amination of unactivated alkanes and aldehydes with diazirines via photocatalysis. This method provides our first approach to acyl diaziridines, which are readily converted to amides, hydrazides, acyl hydrazones and heterocycles.

A full account of the Rawal group’s total synthesis of (+)-hinckdentine A is now out in JOC. In pursuit of the “ideal” synthesis, several routes were explored before an indole-based Claisen rearrangement enabled a concise (5 operations) synthesis of the target. The paper was selected as an ACS Editors’ Choice and is currently free to read: pubs.acs.org/doi/10.1021/ac… #OrganicChemistry #TotalSynthesis #JOC #ACSEditorsChoice #ChemistryNews #VireshRawal #UChichemistry

Nitrate reduction enables Sandmeyer reactions without sweat on your forehead – even on 20 mmol scale! Check out our detailed protocol in @OrgSynth and join us on the safer side of diazonium chemistry! Thanks to @MaulideLab for reproducing! 🤝 tinyurl.com/2h3earww