Carter Brzezinski

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Carter Brzezinski

Carter Brzezinski

@sp3intermediate

Biocatalysis, Pharmacology, Swimming. @KFBChem Postdoc @WuestLab alumni (‘25) @KenyonCollege swammer & alumni (‘20) he / him / his 🇯🇵

Atlanta, GA Katılım Eylül 2019
635 Takip Edilen578 Takipçiler
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Carter Brzezinski
Carter Brzezinski@sp3intermediate·
Check out @HJLChem and I’s recent report on using VHPO enzymes to prepare oxindoles and spiro-oxindoles! Excited to see this work out and help eliminate the need for hazardous halogenating reagents and harsh oxidants. Go team VHPO!
Kyle F. Biegasiewicz@KFBChem

KFB Lab Alert: Our general biocatalytic platform for the oxidative rearrangement of indoles is now online at @ChemRxiv! Congratulations to @HJLChem and @sp3intermediate for leading this work with Sergio, Raina, Ana, Sophie, and John! chemrxiv.org/engage/chemrxi…

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Garg Lab UCLA
Garg Lab UCLA@GargLab·
Recently, Ben and Allison published a procedure for the enzymatic saponification of esters containing β-leaving groups in @OrgSynth. Many thanks to Kevin Campos and the team @Merck for checking, and congrats to the authors! Read it here: orgsyn.org/demo.aspx?prep… @uclachem
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Carter Brzezinski
Carter Brzezinski@sp3intermediate·
The incorporation of enzymatic reactions in natural product total synthesis in the past few years is so awesome and inspiring - I really feel like this has ramped up recently. Enzymes are great for everyone, not just process chemists!
Chao Li Lab@LabChao

Our latest work shows how modern total synthesis can enable therapeutically meaningful discovery, uncovering selective anti-C. difficile activity and toxin-protective effects of structurally complex polyether ionophores. Now available on ChemRxiv: chemrxiv.org/doi/full/10.26…

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Chao Li Lab
Chao Li Lab@LabChao·
Our latest work shows how modern total synthesis can enable therapeutically meaningful discovery, uncovering selective anti-C. difficile activity and toxin-protective effects of structurally complex polyether ionophores. Now available on ChemRxiv: chemrxiv.org/doi/full/10.26…
Chao Li Lab tweet mediaChao Li Lab tweet mediaChao Li Lab tweet media
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Carter Brzezinski
Carter Brzezinski@sp3intermediate·
@Braden_Keith It’s juicy, but “the absolutely juciest newsbit that swimming has had in quite some time”?
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Braden Keith
Braden Keith@Braden_Keith·
Boooo I’m annoyed by nobody being as excited about this as I am. The internet has messed up all y’all’s chemicals lol.
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Taku Mizutani
Taku Mizutani@TM81241003·
Our @J_A_C_S paper is out! We found a unique PLP enzyme that builds α-hydroxy β-amino acids. Can’t wait to make more and more strange amino acids with this guy! pubs.acs.org/doi/10.1021/ja…
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Lopchuk Lab
Lopchuk Lab@LopchukLab·
Today in ChemRxiv, we report the C-H amination of unactivated alkanes and aldehydes with diazirines via photocatalysis. This method provides our first approach to acyl diaziridines, which are readily converted to amides, hydrazides, acyl hydrazones and heterocycles.
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UChicago Chemistry
UChicago Chemistry@UChiChemistry·
A full account of the Rawal group’s total synthesis of (+)-hinckdentine A is now out in JOC. In pursuit of the “ideal” synthesis, several routes were explored before an indole-based Claisen rearrangement enabled a concise (5 operations) synthesis of the target. The paper was selected as an ACS Editors’ Choice and is currently free to read: pubs.acs.org/doi/10.1021/ac… #OrganicChemistry #TotalSynthesis #JOC #ACSEditorsChoice #ChemistryNews #VireshRawal #UChichemistry
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Ritter Lab
Ritter Lab@ritter_lab·
Nitrate reduction enables Sandmeyer reactions without sweat on your forehead – even on 20 mmol scale! Check out our detailed protocol in @OrgSynth and join us on the safer side of diazonium chemistry! Thanks to @MaulideLab for reproducing! 🤝 tinyurl.com/2h3earww
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Kyle F. Biegasiewicz
Kyle F. Biegasiewicz@KFBChem·
KFB Lab Alert: Our latest work on VHPO-mediated cryptic diazo generation to access triazolopyridines is now out @JOC_OL! Congratulations to @ManiksharmaASR for leading this work! pubs.acs.org/doi/10.1021/ac…
Kyle F. Biegasiewicz@KFBChem

KFB Lab Alert: Our latest work on accessing triazolopyridines through cryptic diazo formation with VHPOs is now available @ChemRxiv! Congratulations to @ManiksharmaASR on a fun new application of enzymatic halide recycling! chemrxiv.org/engage/chemrxi…

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Laszlo Kurti
Laszlo Kurti@kurtilaszlo·
Excited to share our ChemRxiv preprint on de novo pyrrole synthesis via an aza-Michael/oxaza-Cope/aromatization cascade from O-vinylhydroxylamines. Congrats to Charlotte, Zach as well as Oleksander and Pavel (@MykhailiukChem) at Enamine (@EnamineLtd)! chemrxiv.org/doi/full/10.26…
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Kyle F. Biegasiewicz
Kyle F. Biegasiewicz@KFBChem·
KFB Lab Alert: Our first efforts in biocatalytic chlorination of aliphatic amines is now online @ACSCatalysis! Huge congratulations to @EJGChem, @sp3intermediate, Sophie, @Logan_Zane97, and John! pubs.acs.org/doi/10.1021/ac…
Kyle F. Biegasiewicz@KFBChem

KFB Lab Alert: Our first efforts in biocatalytic chlorination of amines is now online @ChemRxiv! Congratulations to @EJGChem for leading this work with Sophie Barthel! GO VHPOs! chemrxiv.org/engage/chemrxi…

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Carter Brzezinski
Carter Brzezinski@sp3intermediate·
@Braden_Keith @kylesockwell Gotcha ok. I live like 20 min from GT and want to take my gf to see a session so if you happen to hear about two tickets for Saturday I’d take you up on it!
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Braden Keith
Braden Keith@Braden_Keith·
@sp3intermediate @kylesockwell You can usually buy them on walk-up if there are any left. GT is big so there should be some left. Also work your connections - there's always teams and people with extra tickets. Will let you know if I hear of any.
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Carter Brzezinski
Carter Brzezinski@sp3intermediate·
@Braden_Keith is there no option to buy single-session tickets for NCAAs in ATL??? Is this usually the case??? Would kill to see a session or two but not for $180… cc @kylesockwell
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Kyle F. Biegasiewicz
Kyle F. Biegasiewicz@KFBChem·
Very honored to have our VHPO-catalyzed oxidative rearrangement of indoles highlighted in OPRD! Thanks so much, John and team! pubs.acs.org/doi/10.1021/ac…
Kyle F. Biegasiewicz@KFBChem

KFB Lab Alert: Our general biocatalytic platform for oxidative rearrangement of indoles is now online @ACSCatalysis! Congratulations to @HJLChem on leading this effort alongside an excellent team of @sp3intermediate, Raina, Ana, Sophie, and John! pubs.acs.org/doi/10.1021/ac…

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Emory University
Emory University@EmoryUniversity·
After treatment @emoryhealthcare, 19-year-old Andrew Miles is the second person in the U.S. to live outside a hospital with a total artificial heart. The teenager was born with a heart defect that led to untreatable heart failure. 🔗 Full story: links.emory.edu/1oa
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Keşfet

@OrgSynth @Merck @uclachem @LabChao @Braden_Keith @J_A_C_S @MaulideLab @JOC_OL