Tom Charde

@jannamoen @jewstein3000 Can I (privately) send you an invite to a related FB group?

@jewstein3000 I did my PhD and my first postdoc in nicotinic receptor pharmacology. Low dose nicotine likely helps in 2 ways - 1) stimulating anti-inflammatory pathway and 2) changing receptor expression/function. Nicotine has a lot of weird dose, route, and time-dependent properties.

I know nicotine helps people with Long Covid/ME manage their symptoms, but I do wonder: If the theory that Covid dislodges from the body when you use nicotine were true, wouldn't smokers be doing better with Covid? They discovered this with Parkinson's after all.

@organichemusic Maybe you’re allergic to wild turkeys!

9 days ago, I got my 1st NOVAVAX. The good & bad: 👍Less fatigue & fewer migraines. I even went on a (slow) 2-hour walk today, explored my new neighborhood, & saw some wild turkeys! 🦃 👎Developed new symptoms--pruritus & hives--that have intensified over past week.

Enough about TikTok, how will you recover our stolen pandas? #GOPDebate

Moderator: How will you repeal Obamacare? Pence: Pass. #GOPDebate

@GlobeScotLehigh Also because half the candidates can’t understand her.

Prediction: This is the last time a Univision newswoman will be included as a questioner in a Fox debate. She is asking too many tough, against-the-conservative-grain questions. #GOPDebate

Haley's health care plan literally involves magic. #GOPDebate

FACT: Mike Pence has never answered a question in his life. #GOPDebate

Would Vivek be a good president? Don’t know, but that guy can really enunciate words loudly. #GOPDebate

@MsTrinaDiamond They pulled him out of the audience as part of a contest.

@nokinidea @ProfBrianCox Quantum communication.

A few more thoughts on the possibility of life beyond Earth. All these thoughts are guesses. The lack of firm evidence for alien intelligence (so far) is sometimes called the Fermi Paradox, and it is a paradox. Put simply, there has been over 10 billion years and there are many millions of worlds in the Milky Way on which a civilisation could have arisen as far as we know. At first sight, one might therefore expect that there should be many civilisations in the galaxy far in advance of us, and we might have expected to see them. Why don’t we (or, let’s be careful, why is the evidence not bloody obvious!)? One answer might be that civilisations never develop interstellar travel. I don’t see any reason why interstellar travel is impossible, and I think we’ll develop it if we survive into the 22nd century. Related - perhaps civilisations don’t ever solve the problems posed by industrialisation and the discovery of nuclear weapons and never make it to the stars. Topical - see Oppenheimer!Maybe just ‘getting along’ as a global civilisation is harder than science. Maybe (see UFO hearings) they are here but we haven’t discovered them or somebody knows but has managed to keep it a secret? Maybe. But if this is the case then at least I can say that the alien civilisations aren’t making their presence very obvious, otherwise my Astronomy colleagues who spend their time gazing at the sky and listening for signals would surely have spotted them! But let’s not rule out the possibility that we just haven’t detected them (or there is evidence but only a few people know about it) but they are indeed here. My guess is that the average number of civilisations in a typical galaxy is low - perhaps less than 1. That’s a guess, based on what we know about the evolution of complex life on Earth. Put simply, it took the best part of 4 billion years here to go from cell to civilisation, and that’s a third of the age of the Universe. I think this MAY imply that, if this is typical (lots of ifs) then the Milky Way may be filled with microbes but not complex living things at our level of intelligence. This would be my guess. BUT make no mistake, I wouldn’t be in the least bit surprised if a UFO landed in Oldham town centre tomorrow morning and the captain said ‘Take me to the leader of Oldham Metropolitan Borough Council’. In that case the Fermi Paradox would no longer be a paradox, I’d have learnt a lot about biology and I could get back to tweeting about other interesting stuff. I’d also ask them why gravity is so weak relative to the other forces of Nature.

@JulFal @J_Ran85 @NateMonroeTU Where did you read that it “fell through”? themosh.org/shahid-khan-an…

@tomcharde @J_Ran85 @NateMonroeTU Again, any research outside of 2020 shows that this fell through and never happened. It’s just gotten candy headlines for people who don’t follow up… I was born and raised here. I know where the improvement is…. None of it is due to a fucking BILLIONAIRE.

at an event purportedly for the public to learn more about this proposal, someone gets upbraided for asking a perfectly reasonable question

@JulFal @J_Ran85 @NateMonroeTU si.com/nfl/jaguars/ne…

@J_Ran85 @NateMonroeTU I see people say he’s done “so much for Jacksonville and it’s people.” No he hasn’t….?!

@JulFal @J_Ran85 @NateMonroeTU bigcatcountry.com/2021/5/21/2244…

@ShannonL_Miller @Adweek Very awkward and disjointed. Felt almost like they used AI to come up with the concept.

The Remy Martin ad is so deeply confusing that it caused total disarray in our newsroom. Serena looks amazing, though. #BigGameReviews

@organichemusic This is great data. Any insights as to which symptoms are helped by LDN? (I can’t remember if that was a question on the survey.)

Reviewing preliminary data from the survey (n=1,750!), here are some early observations on a few treatments: 1) Both #pwLC and #pwME benefit remarkably similarly from LDN. Check out the almost identical survey results for overall benefit & number of symptoms improved.

@organichemusic Done! Suggestion: Not clear if that final fill-in-blank on some screens pertained to the set immediately above it, or to any sets on screen.

TREAT ME covers 150+ medications & supplements. Treatments were selected based on published trials, case reports, other relevant studies, results of earlier surveys I’ve written, direct patient accounts (incl lots of feedback from many of YOU🥰), and my own pharmacist intuition.

Hi everyone! I am very excited to announce that I have finally completed a massive #ME/CFS & #LongCOVID treatment survey entitled "TREAT ME"‼️🎉🤩 If enough people respond thoughtfully, I’m confident we may push research in the field forward!🏇 🧵1/3 surveymonkey.com/r/TREATMEANDLC

@AlphaBetaDelta4 @mikeleprestia @organichemusic Just to make sure I understand: Taken only in AM = tired all day. Taken AM + PM = no tiredness in day?

@mikeleprestia @tomcharde @organichemusic Brilliant, it was the strangest thing - I had no idea what was going on the first time!