BurkeLab

New Paper out! In cooperation with the Wöhnert Lab in Frankfurt and @ABousseb

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

If you’re into DNA, go to minute 13-14. This is so cool!

@benoitbruneau @bthomasZOU

If I see another paper titled “Single cell RNASeq reveals…”

Almost all our pubs are collaborations... We just submitted a great piece yesterday. Collaborator wrote to me: "It's a productive collaboration between your lab and mine. Neither lab alone would have achieved what we got." ... and that's why. 😃

Structural mechanisms of HIV-1 capsid lattice stabilization

Keeping my distance from 'X' these days. Hence the silence. What alternative social media platforms are ppl using these days? What makes it 'better' (apart from absence of the distasteful parts of 'X')?

#SAMURI is a new #ribozyme for RNA-catalyzed labeling of RNA. It uses a new cell-permeable SAM analogue and generates a novel propargylated nucleotide in RNA. Check out the full story doi.org/10.1038/s41557… rclcu.be/dlcxN

@jackcschultz @DamonLisch We understand the world through our models of how it works Hypotheses are predictions that illuminate the model. If…then. Gotta shake it! If the model breaks when we shake it, it needs more thought If we can’t break it — ie the model makes good predictions — it may be useful

@DamonLisch I don't think this is understood by many more-senior scientists. I once collaborated with a famous member of the National Academies whose approach was to "repeat the experiment until you get the right answer". There's a lot wrong with science and scientists.

I'm starting to feel as if we are doing a bad job at teaching grad student how to do science. One after another has acted surprised, and often genuinely puzzled, when I tell them that testing a hypothesis means doing your best to disprove it, not trying to prove it.

I think I’ll spend tomorrow ‘Writing.’

@OdedRechavi All of biology is interconnected Rube Goldberg machines Omit a piece and see whether you can guess the missing piece without referring to an analogous system ‘Tis humbling to those of us who would build new biologies or study its origins! #SynBio #OoL #Astrobiology #RNAWorld

MAP kinase kinase kinase twitter.com/InnovationHack…

Happy pi approximation day! Today's date, 22 July, can also be written as the fraction 22/7, which is equal to 3.14285714, an approximation of π, correct to two decimal places.

@sonukg4india Clock

#How?

@AmitKahana Sooooooo maaaany proposals fail to allow for a meaningful outcome in which an informative null hypothesis could prove their core ideas to be wrong. Those proposals don’t score well.

@IvaZovkic WestWorld prototypes.

Just spotted these in the hallway. What are they?? They look like studying cages

@jackcschultz @ADHansonLab I’ll bet that @jackcschultz has a few examples …

@BurkeLabRNA @ADHansonLab "But chemists’ priorities are not always most relevant to biology" 🤣🤣🤣🤣🤣🤣

“Life is chemistry that remembers.” — Karyn Rogers

@BurkeLabRNA A Biochemist and a Geologist walk into a bar and try to solve the origins of life problem. Bartender to them: how on earth did life begin? Them: Exactly!

@OxonAndrew @ThePhDPlace Cardinal rule in my lab. Do not reinvent the wheel ripping apart peer-reviewed, published research papers just for making a dissertation chapter. Adjust figure numbers (eg, fig 4 ➡️ fig 3.4 of chapt 3). Insert SI somewhere logical and findable. IDC where. Keep refs as is. Go!

@ThePhDPlace I realise all your thesis chapters are already published but I’d like you to make these pointless changes to the figures, tables and format—would you like an extension?

Annoy a PhD student in one tweet

@munozfortik Pitch it. Pitch it good.

@SaurjaDasGupta Another of her quips: “A Biochemist and a Geologist walk into a bar and try to solve the origins of life problem. Not a joke. That’s just what we do!” Karyn Rogers, describing PCE3 (Prebiotic Chemistry and Early Earth Environments, one of NASA’s RCNs. #OoL #Astrobiology

@BurkeLabRNA This is a brilliant 5 word summary!