Benoit Bruneau

Two flights in 8 hours cancelled by Air Canada for mechanical reasons. No more confidence in @AirCanada and yet I don’t have a fucking choice if I want to go to Montreal or Toronto bc @united is too lazy to go there. Missing time with my mother that I can’t get back

@AirCanada you canceled two (2!!) flights I was on today. What the actual fuck? I want to spend time with my mother and you’re killing that. Now I spend 18 hours for what should be an 8 hour trip

@michaelshafrir @anshulkundaje @LocasaleLab My wasn’t eligible. Low platelets that’s it. So.

@LocasaleLab My wife was on this trial. Stage 4 panc cancer, 40 years old. She was in this trial and lived 18 months after chemo stopped working. We took trips to Spain, Disney, Jersey Shore. She got two more birthdays with our kids. Shove your hype and misrepresentation up your ass.

This is exactly the kind of hype and misrepresentation that has defined cancer research and oncology for decades. After 40+ years of work and well over $100B in taxpayer funding, what’s being presented as a revolution is a survival improvement of about 6–7 months. Patients don’t even get an additional birthday. This is now being hyped by the biotech industry and amplified by academic scientists as if it represents some fundamental breakthrough. It doesn’t. What’s even more concerning is that almost no one is calling this out. The same narrative gets repeated, the same approaches get reinforced, and the same cycle continues. Billions of taxpayer dollars will continue to fund this. Venture capital will continue to flow into biotech companies built around these claims. Pharma will continue to allocate time and resources here. Healthcare expenses for the public will continue to be greater than ever. Meanwhile, entire areas of cancer research and oncology practice—particularly early detection and prevention—remain neglected.

Don't miss out on this year's Weinstein Conference on Cardiovascular Development & Regeneration, in New York, May 6-8! weinstein-conference.com Apply for a travel award ($500-1,000) by April 10th by filling out the following form: forms.gle/kpvL3oR3sQFc5N…

Excited to share MaxToki, a temporal AI model that predicts the impact of perturbations on cell states over time along dynamic trajectories. We applied MaxToki to predict how cells age across the human lifespan & discovered new cardiac pro-aging drivers that we validated in vivo.

Hi @united UA1844 1/31/2026 does not have screen power and the rear restrooms (it’s a 757) are non-functional (only one now for the entire economy set). We’ve paid a lot including those of us in business. I’m returning from a family tragedy and was hoping for better.

@fujigenguitars Fujigen used to make the Roland G-303. Can anyone find out how many lefty units were made?

“This is a court of law, not a court of morals,” he said” Oh what a terribly missed opportunity here!

@matthewhirschey really cool. Did they misspell your name or is that intentional?

N.B. This mosaic artwork depicts various cellular components as distinctly colored and textured pieces within a circular frame, with a dividing cell at the center surrounded by organelles and molecular structures. The image represents how the GAUDI algorithm transforms disparate multi-omics data types into a unified biological understanding—each mosaic piece symbolizes different omics layers (genomics, proteomics, metabolomics) that maintain their unique characteristics while forming a cohesive whole. Our algorithm's name honors Spanish architect Antoni Gaudí, famous for creating stunning mosaics from broken ceramic pieces—similarly, GAUDI reveals interpretable patterns from fragmented biological information.

Multi-omic data integration is hard. GAUDI is a new tool that helps scientists analyze multiple types of biological data from cells all at once.

How does heart failure rewire gene regulation? 🔍 Excited to share our single-cell, multimodal epigenomic resource on human heart failure🫀: doi.org/10.1101/2025.0….

@bettieliu @WJGreenleaf The most important! Incidentally the Meis motif you call (TGACA) is also a T-box motif (see Luna-Zurita et al 2016) so that in combination with another could also be relevant to other cell types.

@benoitbruneau @WJGreenleaf TBX motifs do show up as significantly enriched motifs in the ATAC marker peaks in an aCM cluster in the heart and an excitatory neuron cluster in the brain (Supp note 2) as well -- they are indeed important motifs for development

Pleased to announce this latest work from the lab!

Grateful & humbled to make the 2025 #TIME100HEALTH list with such inspiring global health leaders. This honor reflects my team, who are unrelenting in their efforts to advance new treatments for pancreatic cancer!

@RolandGlobal I'm trying to figure out how many left-handed G-303 controllers were made, and what year mine was made. I have this one (B832303):

for #heart month, a nice piece on what we at @GladstoneInst are doing to understand heart disease better. Featuring @m_alexanian @TheodorisLab and Katie Pollard. for heart month, a nice little piece on what we do at Gladstone for the heart gladstone.org/news/matters-h…

The latest from @GladstoneInst of Cardiovascular Research and @ucsf: Isha Jain's lab, with an outstanding discovery of a small molecule that mimics hypoxia, to treat neurodegenerative diseases. The amazing Sylar Blume, RA in Isha's lab, is first author! cell.com/cell/fulltext/…

reupping this request to support my daughter's fundraising efforts for the @americanheart It's a worthy cause, and she is learning a lot from it. Thank you for considering. www2.heart.org/site/TR?px=289…

Hey there! Please consider supporting my daughter Nika as she raises funds for the American Heart Association as a 2025 Teen of Impact nominee. More than ever we need support for cardiovascular research, and this is a noble way to help. Thank you! www2.heart.org/site/TR?px=289…

@RolandGlobal how many left-handed GR-300 guitar synth controllers were made? I have recently acquired a 1980 unit and it's amazing.

@rickbeato @YouTube I would kill for a Robert Fripp interview!

Maynard James Keenan’s 2025 Vision: A Follow-Up Interview youtu.be/kf0JnYcUgrE?si… via @YouTube