Colin Nichols Lab @colinnicholslab.bsky.social

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Mitochondrial Ca2+-coupled generation of reactive oxygen species, peroxynitrite formation, and endothelial dysfunction in Cantú syndrome @vesselman @ColinNicholsLab @JCI_insight insight.jci.org/articles/view/…

The study has important implications both for monogenic KATP channel diseases and for more common brain pathologies. 4/n

We reveal the dramatic effects of either increasing or decreasing SUR2/Kir6.1-dependent KATP activity on NVC, whether pharmacologically or genetically induced. 3/n

Check out our new publication "Control of neurovascular coupling by ATP-sensitive potassium channels" @Nyorkster91 @SageJournals journals.sagepub.com/doi/10.1177/02… A 🧵 1/n

Join us today for a new exciting CIMED seminar! @zubcevic_lejla @WUSTL

We show that insulin secretion can be restored when intracellular Ca2+ is artificially elevated by increasing extracellular Ca2+. 4/n

In this study we examine this phenomenon, demonstrating that the lack of insulin secretion is the result of an apparent reduced sensitivity to Ca2+. 3/n

Check out our new publication "Loss of β-cell KATP reduces Ca2+ sensitivity of insulin secretion and Trpm5 expression" @Nyorkster91 @ADA_Pubs diabetesjournals.org/diabetes/artic… A 🧵 1/n

Today!

Next Monday, join us for a new exciting CIMED seminar! @RohacsTibor @WUSTL

Join us today for a new exciting CIMED seminar! @WUSTL

Join us today for a new exciting CIMED seminar! @WUSTL

Cell bio department retreat! @MariaSRemedi

Excellent thesis defense by Dr. Gao! Congratulations Jian, we are very proud of you! 🥳

Join us today for a new exciting CIMED seminar! @SlavBagria @WUSTL

Congratulations to Drs. Irfan Lodhi, Jeffrey Millman, Maria Remedi, and Julie Silverstein on achieving full professorship in their careers! Learn about each of their journeys: bit.ly/3Xs4FyM. @JeffreyRMillman @LodhiLab @WUDeptMedicine

The specific location of the variant also reveals an unrecognized functional role of the first glycine in the signature motif of the nucleotide binding domains in NBD1 of SUR2 subunits. 4/n

Functional assays reveal that KATP channels containing this mutation exhibit reduced sensitivity to inhibitory ATP compared to WT, providing a molecular explanation of the condition. 3/n

Check out our new publication "A novel ABCC9 variant in a Greek family with Cantu syndrome affecting multiple generations highlights the functional role of the SUR2B NBD1" onlinelibrary.wiley.com/doi/full/10.10… A 🧵 1/n