Fabrizio d'Adda di Fagagna

Can an antisense oligonucleotide (ASO) targeting an RNA that is neither coding nor encoded by a gene extend the lifespan of a mammal? nature.com/articles/s4146… #DDRNA #ncRNA #telomere #aging #ASO

Happy to share our deep characterization of #LLPS events modulating the DNA damage response (#DDR) through #53BP1 condensation promoted by #dincRNA: biorxiv.org/content/10.648…

Happy to read that @Agenzia_Ansa reported on our work linking #telomere biology to #Alzheimer’s disease link.springer.com/article/10.103…

Now is the turn of @FdAdF66 from IFOM speaking about telomeres and DNA damage at #SENESCEL25 in Barcelona

embopress.org/doi/full/10.10… Today on World Alzheimer's Day we published in @EMBO Journal that #Alzheimer's diseases (#AD) is associated with DNA damage at #telomeres and that inhibition of telomeric DNA damage signaling with telomeric #ASO improves neurons cell viability.

#ICSA2025Rome ⁦@ICSA_senescence⁩ ⁦@PhaedonInstitut⁩ with ⁦@MarcoQuarta12⁩ ⁦@martakova⁩ ⁦@Demarialab1⁩

Thank you @robertafulci for the dialogue on #longevity on national radio Rai @Radio3scienza raiplaysound.it/audio/2025/09/…

@GiusepeBellelli Essentially because the method replicates the frailty index. If we use a unitary measure to describe organism aging and we call it frailty, so we can apply the same methods (multidimentional scores) linked to bad outcomes for complex systems and organs — by Marco Malavolta

Nice study but why talk bout cognitive frailty and not age associated cognitive decline? Frailty is a unitary multidimensional concept that doesn’t make sense to break into separate entities

A Novel Cognitive Frailty Index for Geriatric Mice - Marcozzi - 2025 - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/ac…

Weaponizing CRISPR/Cas9 sciencedirect.com/science/articl… Likely our paper with teh coolest title 😎

LO "STUDIOSO"...OVALE!?! Alle 20.00 su #rai3 #blobredux, riassunto della settimana...

We have two open #PhD student positions: join us! semm.it/education/open…

Here is the link rdcu.be/eb9Kq for everybody to read our most recent Review on #aging and #cancer published in @NaturePortfolio Aging coauthored with @LTrastus - happy to read your comments. nature.com/articles/s4358…

Qual è la relazione tra cancro e invecchiamento? Le connessioni sono complesse e articolate. Ecco lo studio di #Ifom, #Airc e #Cnr che analizza i meccanismi molecolari condivisi, anche evidenziando alcune criticità inerenti agli animali 👉cnr.it/it/news/13352 @MC_Carro

I had the incredible opportunity to speak at #TEDxRoma. It was an intense and unforgettable experience. If you attended or watched the talk, feel free to share your thoughts with me! #Aging #longevity #telomere youtu.be/yTGj-5BVLXs?fe…

Lab reunion in Colorado with former members ⁦@JulioAguado_PhD⁩ ⁦@Coreywjw⁩ with the gracious presence of ⁦@FajnerValentina⁩

Feasting on a non vegetarian meal at #ksaging25 with Vittorio Sebastiano and Giovanni Pascarella

Grateful to @cliniqueprairie for their hospitality and the recording of "Episode 32 - Unlocking the secrets of Aging by Fabrizio d'Adda di Fagagna" by Unlock Longevity creators.spotify.com/pod/show/clini…

Thanks to @BacMarg @Corriere for the interest shown in our studies on the impact of #telomere biology on #aging, #age-related diseases and #cancer. They set the bases for TAG Therapeutics tag-therapeutics.com the #startup that will develop this approach for patients

Presentato al @MinisteroSalute un Istituto per il futuro della #popolazione per #invecchiare in modo #attivo. Tra i filoni di ricerca la terapia della #longevità. @Tg1Rai @RaiUno @mur_gov_ @FdAdF66 @AirC @IFOMresearch

Thanks #AriSLA for the constant support and for the opportunity to present our results at your annual conference