valentina fajner

AI lends a hand to drug discovery to fight antibiotic resistance. Check it out on Agenda 17 (links in the comment below) Thanks to @gabrielecostan4 (Unipr) ,@ItsJonStokes (McMaster University) and RiccardoZese (Unife) #Agenda17 #ai #drugdiscovery #amr

Interested in signaling and molecular mechanisms? Join our team at IFOM and we delve into the fascinating realms of ubiquitin signaling and alternative splicing! If you're interested, apply here lnkd.in/dGxHr5q2 and express your interest in our lab #PhD #ubiquitin

Interested in exploring a novel #E3ubiquitinligase in #fruitflies’ nervous system? 1 pre-doc position in @polosimona1 Lab with possibility of PhD in September2023. Multidisciplinary project combining the power of in vivo model, molecular biology &cutting edge-imaging. Plz RT

So tiny, but always full of surprises - why fruit flies don't need a pH meter! #drosophila nature.com/articles/d4158…

So excited to see our latest work about myosin VI and OFD1 published in @emboreports! Thanks to all the authors for this great teamwork, and especially to my mentor @polosimona1

Gli inglesi sono andati a vedere cosa è successo dopo l'introduzione della vaccinazione #HPV; nelle ragazze vaccinate a 12-13 anni i tumori cervicali sono quasi spariti, idem le lesioni CIN3. Le piccole donne meritano questa opportunità #FUVMagazine fondazioneveronesi.it/magazine/artic…

thanks to @polosimona1 @emaspero1 @vaccart @IFOMresearch @LaStatale @FabioGiavazzi @cerbino check it out!➡️ nature.com/articles/s4146…

Welcome to Hecw, the new E3 Ub ligase that controls RNPs’ LLPS in fly ovary and neurons. 🪰If we think at research with a "cathedral thinking”mind, this could be a first brick for a new exciting part of the ‘Science cathedral’. #drosophila #ub #PhaseSeparation #RNP #teamwork

We identified a new member of the NEDD4 family in Drosophila, Hecw, and we generated catalytic inactive and KO mutants to find that lack of Hecw ubiquitination activity results in defective oogenesis, premature aging and climbing defects associated with neuronal loss. 2/4

A wonderful collaboration with Thomas @vaccart. Kudos to @FajnerValentina @elenaspero and all the authors. A huge thanks to @FabioGiavazzi and @cerbino who helped us to analyze the biophysical properties of the RNPs. A short tweetorial 1/4

Finally, Fmrp-regulated mRNA targets are aberrantly expressed in oocyte (Orb, an oocyte determinant) and neurons (Profilin, a causative familiar ALS gene). This last event is particularly intriguing as it opens new possibility for the treatment of this devastating disease. 4/4

The biophysical properties of germ and neuronal RNPs are affected, they become larger and transition from a liquid to a less dynamic gel-like state. We dissected the mechanism and identified the Hecw-relevant target, Fmrp, a conserved RNA-binding translational repressor. 3/4

Today Hecw is ready for its first flight into the Ubiquitin Word! Welcome the new E3 ligase that controls RNPs’ LLPS in #drosophila @IFOMresearch @laStatale #Ubiquitin #E3ligases #RNP #PhaseSeparation #teamwork 👇🏻rdcu.be/cxSJO

"La scienza studia i singoli nutrienti ma noi dobbiamo tradurre la ricerca in alimenti, dieta e salute" @ElenaDogliotti presenta il suo "Una dieta per ogni età" @Sperling_Kupfer @Fondaz_Veronesi #CICAPFEST21 con Elisabetta Bernardi #unadietaperognieta

Quanto sarebbe più facile seguire la #dieta mediterranea se, invece di pesare le #porzioni in grammi, avessimo in mente visivamente quant'è una porzione di verdura? Piccoli trucchi come questi aiutano molto! @ElenaDogliotti con Simona Ovadia al @cicap Fest #CICAPFEST21

" Il tè nasce verde e la primavera è la stagione adatta per farne la conoscenza"#tea pensardicibo.it/2021/04/21/i-t… instagram.com/p/CN-UwFejjGPb…

nature.com/articles/d4158… #artandscience instagram.com/p/CL6edAIjXqWh…

If we want to go full power ahead then the math is simple: half of our World is women, half of our creativity is women, half of our perseverance is women, half of our thinking power is women. Let’s make sure both halves make up the whole of science. #SHELooksLikeAScientist