Monadic DNA

235 posts

Monadic DNA banner
Monadic DNA

Monadic DNA

@MonadicDNA

DNA insights with privacy, autonomy, and boundless curiosity.

Se unió Aralık 2024
64 Siguiendo900 Seguidores
Monadic DNA
Monadic DNA@MonadicDNA·
With the next release of the Explorer app, we will drop support for stock L2s. We will be happy to incorporate any ETH L2s that bring in differentiated functionality.
vitalik.eth@VitalikButerin

There have recently been some discussions on the ongoing role of L2s in the Ethereum ecosystem, especially in the face of two facts: * L2s' progress to stage 2 (and, secondarily, on interop) has been far slower and more difficult than originally expected * L1 itself is scaling, fees are very low, and gaslimits are projected to increase greatly in 2026 Both of these facts, for their own separate reasons, mean that the original vision of L2s and their role in Ethereum no longer makes sense, and we need a new path. First, let us recap the original vision. Ethereum needs to scale. The definition of "Ethereum scaling" is the existence of large quantities of block space that is backed by the full faith and credit of Ethereum - that is, block space where, if you do things (including with ETH) inside that block space, your activities are guaranteed to be valid, uncensored, unreverted, untouched, as long as Ethereum itself functions. If you create a 10000 TPS EVM where its connection to L1 is mediated by a multisig bridge, then you are not scaling Ethereum. This vision no longer makes sense. L1 does not need L2s to be "branded shards", because L1 is itself scaling. And L2s are not able or willing to satisfy the properties that a true "branded shard" would require. I've even seen at least one explicitly saying that they may never want to go beyond stage 1, not just for technical reasons around ZK-EVM safety, but also because their customers' regulatory needs require them to have ultimate control. This may be doing the right thing for your customers. But it should be obvious that if you are doing this, then you are not "scaling Ethereum" in the sense meant by the rollup-centric roadmap. But that's fine! it's fine because Ethereum itself is now scaling directly on L1, with large planned increases to its gas limit this year and the years ahead. We should stop thinking about L2s as literally being "branded shards" of Ethereum, with the social status and responsibilities that this entails. Instead, we can think of L2s as being a full spectrum, which includes both chains backed by the full faith and credit of Ethereum with various unique properties (eg. not just EVM), as well as a whole array of options at different levels of connection to Ethereum, that each person (or bot) is free to care about or not care about depending on their needs. What would I do today if I were an L2? * Identify a value add other than "scaling". Examples: (i) non-EVM specialized features/VMs around privacy, (ii) efficiency specialized around a particular application, (iii) truly extreme levels of scaling that even a greatly expanded L1 will not do, (iv) a totally different design for non-financial applications, eg. social, identity, AI, (v) ultra-low-latency and other sequencing properties, (vi) maybe built-in oracles or decentralized dispute resolution or other "non-computationally-verifiable" features * Be stage 1 at the minimum (otherwise you really are just a separate L1 with a bridge, and you should just call yourself that) if you're doing things with ETH or other ethereum-issued assets * Support maximum interoperability with Ethereum, though this will differ for each one (eg. what if you're not EVM, or even not financial?) From Ethereum's side, over the past few months I've become more convinced of the value of the native rollup precompile, particuarly once we have enshrined ZK-EVM proofs that we need anyway to scale L1. This is a precompile that verifies a ZK-EVM proof, and it's "part of Ethereum", so (i) it auto-upgrades along with Ethereum, and (ii) if the precompile has a bug, Ethereum will hard-fork to fix the bug. The native rollup precompile would make full, security-council-free, EVM verification accessible. We should spend much more time working out how to design it in such a way that if your L2 is "EVM plus other stuff", then the native rollup precompile would verify the EVM, and you only have to bring your own prover for the "other stuff" (eg. Stylus). This might involve a canonical way of exposing a lookup table between contract call inputs and outputs, and letting you provide your own values to the lookup table (that you would prove separately). This would make it easy to have safe, strong, trustless interoperability with Ethereum. It also enables synchronous composability (see: ethresear.ch/t/combining-pr… and ethresear.ch/t/synchronous-… ). And from there, it's each L2's choice exactly what they want to build. Don't just "extend L1", figure out something new to add. This of course means that some will add things that are trust-dependent, or backdoored, or otherwise insecure; this is unavoidable in a permissionless ecosystem where developers have freedom. Our job should make to make it clear to users what guarantees they have, and to build up the strongest Ethereum that we can.

English
0
0
3
196
Monadic DNA
Monadic DNA@MonadicDNA·
🧬 ACTG1P22 locus variant rs1380703 increases habitual sleep duration by ~1–2 minutes per allele. In a genetic analysis of 127,573 adults, Jones et al. (2016) found that rs1380703 mapped to the ACTG1P22 gene is associated with longer self-reported sleep duration. Impact: Each copy of the A allele increases sleep duration by β ≈ +0.025 hours, which corresponds to ~1.5 minutes more sleep per night per allele on average. Statistical strength: p = 3 × 10⁻¹⁰, with independent replication in 47,180 individuals. Explore this variant in your own genome using Monadic DNA Explorer explorer.monadicdna.com Study: Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci Jones et al., 2016 PubMed: pubmed.ncbi.nlm.nih.gov/27494321/
Monadic DNA tweet media
English
0
0
2
193
Monadic DNA retuiteado
Nillion Ecosystem
Nillion Ecosystem@Nillioneco·
If you're a trader and have taken a genetic test before, this is for you. Participate in @MonadicDNA's campaign to find out if your risk appetite is genetic. More details 👇
Nillion@nillion

Your trading risk appetite might be genetic. Degens and non-degens take risk very differently. @MonadicDNA is running a community study using Nillion to process private genetic data to find out answers to all of these questions and more!

English
1
1
7
1K
Monadic DNA retuiteado
Lukas
Lukas@0xlukeskywalker·
Are your degen traits all driven by your DNA? This is the study launched by @MonadicDNA on @nillion. Upload your DNA data and benefit from private AI analysis on @nillion to determine how much of a degenerate you are by nature 👀
Nillion@nillion

Your trading risk appetite might be genetic. Degens and non-degens take risk very differently. @MonadicDNA is running a community study using Nillion to process private genetic data to find out answers to all of these questions and more!

English
2
1
11
530
Monadic DNA retuiteado
Nillion Việt Nam 🇻🇳
Nillion Việt Nam 🇻🇳@Nillion_VN·
Khả năng chấp nhận rủi ro khi giao dịch của bạn có thể do di truyền. Những người chơi cá cược liều lĩnh và những người không phải là người chơi cá cược liều lĩnh có cách nhìn nhận rủi ro rất khác nhau. @MonadicDNA đang thực hiện một nghiên cứu cộng đồng sử dụng Nillion để xử lý dữ liệu di truyền cá nhân nhằm tìm ra câu trả lời cho tất cả những câu hỏi này và hơn thế nữa! x.com/nillion/status…
Tiếng Việt
1
1
4
277
Monadic DNA
Monadic DNA@MonadicDNA·
Most of the computation happens locally on your device. The LLM inference happens inside a Trusted Execution Envrionment (TEE) provided by @nillion nilAI!
☙ tenitoka ❧(privacy szn)@tenitoka_eth

@nillion @MonadicDNA how does nillion keep the genetic data fully private during the whole study? like no one sees my raw dna even when computing the risk stuff? this is dope for privacy

English
1
1
6
458
Monadic DNA retuiteado
Nillion
Nillion@nillion·
Your trading risk appetite might be genetic. Degens and non-degens take risk very differently. @MonadicDNA is running a community study using Nillion to process private genetic data to find out answers to all of these questions and more!
English
25
24
218
25.1K
Monadic DNA
Monadic DNA@MonadicDNA·
Regular genomics apps give you access to up to a hundred traits. Monadic DNA Explorer lets you securely access up to a million traits. explorer.monadicdna.com
English
0
0
1
227
Monadic DNA
Monadic DNA@MonadicDNA·
If you have your raw DNA data, you’re probably underusing it. Monadic DNA Explorer Premium is now live.
Monadic DNA tweet media
English
1
3
13
41.5K
Monadic DNA retuiteado
Angelo
Angelo@purebreedtrader·
@nillion Can't imagine genomics running on anything that isn't inherently private
English
0
1
2
359
Monadic DNA retuiteado
Jack Sedart
Jack Sedart@jacksedart·
Interested in genomics? This tool is for you. It lets you explore genetic studies, and you can filter the ones that are relevant to you by uploading the results of popular genomic tests like 23andMe, Ancestry, etc. @nillion AI can then break it down for you. Privately🔒.
Monadic DNA@MonadicDNA

Monadic DNA Explorer now uses @nillion's nilAI mainnet instance. ⚡️LLM analyses run much faster now. 🤖 gpt-oss-20b provides more intelligent commentary on genetic traits

English
0
1
8
395
Monadic DNA retuiteado
Lukas
Lukas@0xlukeskywalker·
analyzing genetic traits with AI on @nillion beyond exciting to see the new real use cases emerging on privacy infra that go beyond purely financial primitives.
Monadic DNA@MonadicDNA

Monadic DNA Explorer now uses @nillion's nilAI mainnet instance. ⚡️LLM analyses run much faster now. 🤖 gpt-oss-20b provides more intelligent commentary on genetic traits

English
1
1
12
953
Monadic DNA
Monadic DNA@MonadicDNA·
Monadic DNA Explorer now uses @nillion's nilAI mainnet instance. ⚡️LLM analyses run much faster now. 🤖 gpt-oss-20b provides more intelligent commentary on genetic traits
Monadic DNA@MonadicDNA

Introducing Monadic DNA Explorer: Private genomic analysis with secure AI 🧬 Explore ~1 million genetic trait associations from @GWASCatalog and analyze your DNA entirely in your browser. Your data never leaves your device! Optional secure LLM analysis with TEEs! Blog post 👇

English
2
8
72
21.7K
Monadic DNA
Monadic DNA@MonadicDNA·
Thank you! Currently we do not perform any sequence alignment. We use genotype data from different providers which have already been aligned using standard methods. We will offer our own secure sequencing in the future. See nillion.com/news/preservin… for work we advised @nillion on.
English
0
0
0
20
Furkan ☁️
Furkan ☁️@furkanakal·
@MonadicDNA Hey! I really appreciate what you guys are doing and that you're one of the few people caring about confidential healthcare and medicine. What I'm curious about is how you're handling confidentiality-needed stuff like sequence comparison-based operations.
English
1
0
2
83
Monadic DNA
Monadic DNA@MonadicDNA·
Monadic DNA Explorer never handles user data on its servers. All user data processing happens locally in your browser. Results are stored transiently in memory, and you have complete control with the option to export and import results from disk. The app maximizes anonymity and privacy at every step.
Monadic DNA@MonadicDNA

Introducing Monadic DNA Explorer: Private genomic analysis with secure AI 🧬 Explore ~1 million genetic trait associations from @GWASCatalog and analyze your DNA entirely in your browser. Your data never leaves your device! Optional secure LLM analysis with TEEs! Blog post 👇

English
1
0
5
388