Ralph Manders

803 posts

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Ralph Manders

Ralph Manders

@RalphManders

Senior-Lecturer in Exercise Physiology at University of Surrey. Research interest: Exercise, Nutrition, Ageing, Diabetes, Cancer

England, United Kingdom Se unió Eylül 2017
406 Siguiendo341 Seguidores
Ralph Manders retuiteado
Nicolas Hart
Nicolas Hart@DrNicolasHart·
Feasibility and implementation outcomes of our global Phase III RCT examining vigorous exercise for survival in advanced prostate cancer. 🚨The GOOD news🚨: 1-Year of vigorous hybrid-supervised exercise in men with advanced prostate cancer ( resistance and aerobic; 3 days per week ) had high adherence ( median: 84% ), and was well tolerated ( only 19 study-related adverse events among 145 randomised participants ) in people with a variety of complex multimorbidity profiles and concomitant medications: lnkd.in/gzJD2FY2 🚨The CHALLENGES🚨: Global study feasibility across the world was variable (13 of 21 activated sites actually recruited; with 4 sites recruiting ~80% of participants on-study). The study closed early as a result ( randomising n=145 of its n=866 target ), acknowledging COVID-19 dramatically hampered efforts which cannot be understated. 🚨The LESSONS🚨: We report our experience designing and implementing a global RCT across the world (7 countries) and highlight the key issues faced, and lessons or recommendations for others who seek to run similar trials in future. While our INTERVAL-GAP4 trial was on track to run a similar time horizon to the CHALLENGE trial; these trials are expensive and long-lasting (with evolving cost bases), thus our INTERVAL-GAP4 trial was not supported to continue following an interim analysis. 🚨What’s NEXT?🚨: We have excellent data on n=145 men with metastatic prostate cancer involved in a 2-year exercise study. Many helpful outcomes will arise from this comprehensive trial. A forthcoming paper will present the survival and physical fitness efficacy outcomes, for example. We hope the detailed information here (such as which types of trial sites worked best) helps in the design and realistic operation of future multinational large-scale trials by study teams and funders of this type of multidisciplinary work. Read our article in full here: lnkd.in/gzJD2FY2 We are grateful to the vision and ambition of @MovemberAUS / @Movember to support this trial among its suite of Global Action Plans nearly 15 years ago. How much the world has changed since! @EurUrolOpen
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Ralph Manders retuiteado
🎸 Rock History 🎸
🎸 Rock History 🎸@historyrock_·
Ozzy Osbourne has passed away at the age of 76. I still can't believe it. A few weeks ago he was giving his final concert. I hope you came home, Ozzy ❤️
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Nicolas Hart
Nicolas Hart@DrNicolasHart·
Extremely honoured to be promoted to Professor at @UTSEngage. I’ve been blessed with excellent mentors over my career, and grateful to have incredible colleagues who I rely on heavily. And I am most thankful to my parents (and Baxter 🐕) for their unconditional love and support.
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Ralph Manders retuiteado
Sport & Exercise Science @ University of Surrey
Semi-Professional Footballers Read Below 👇👇 I am looking for semi-professional footballers to participate in a Questionnaire based study The aim is to investigate the impact of strength training regimens on the injury risk in male semi-professional football players...
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