Yi Chai

Happy to share the 1st 1st-author PhD publication by my 1st RPg student @YuqiHu_! Published in @PLOSMedicine, findings demonstrate an elevated but rather rare risk of hematological malignancy associated with clozapine use #Cancer #schizophrenia dx.plos.org/10.1371/journa…

Our study in @BMCMedicine showed a significant increase in the risk of multiple disease outcomes associated with the severity of COVID-19 infection, both during the acute and post-acute phases. bmcmedicine.biomedcentral.com/articles/10.11…

Assessment of COVID-19 with complications post acute phase. Read the full study from @EricWan_HKU @Ranzhang_hku @Sukrit_Mathur99 @VincentKCYan @FranciscoTTLai1 @ChuiCeline @snowly12191 @CarlosWongHKU @Esther_CSMPRHKU @Ian_HKU and colleagues here: bmcmedicine.biomedcentral.com/articles/10.11…

Study in @BMCMedicine showed the significant increased risk of multiple disease outcomes with increasing severity in both acute and post-acute phases of #Covid_19 infection, especially among elderly population. doi.org/10.1186/s12916…

Our study using self-controlled case series study showed no increased risk of neuropsychiatric events after fluoroquinolones exposure, with amoxiclav as the active comparator. @hku_son @hkumed @HKU_SPH @HKU_D24H @LSHTM @CSMPR_HKUPharm doi.org/10.1002/pds.70…

Our study reveals persistently elevated rates of psychotropic drug prescriptions beyond the initial phase of the pandemic among patients with depression and anxiety in the post-pandemic era. The Lancet Psychiatry thelancet.com/journals/lanps…

Extending early intervention services (EASY Plus) for patients with first-episode schizophrenia aged 15-64 in Hong Kong was associated with reduced self-harm and suicide rates over 20 years, this study finds. ja.ma/3WFXWiY

Study by @Yi_Chai18 found that early intervention services #EIS was associated with reduced #selfharm and #suicide rates among all patients with first-episode #schizophrenia #FES. Full study: doi.org/10.1001/jamane… @HkuPharm #CSMPR #HKU #HKUMed #HKUPharm #pharmacy #research

Our amazing work on a seemingly simple but important evidence in @AnnalsofIM that statins work well even in old people aged ≥ 85 yrs. Thanks awesome students @Wanchun_Xu, Amanda, supervisor @CindyLan897569 and @HarvardChanSPH collaborator @GDanaei. doi.org/10.7326/M24-00…

Our work ⁦@BMCMedicine⁩ found 21% of depression incidence increasing during the pandemic but 11-16% less health service used compared with pre-pandemics. The system is recovering with service rebound over 3 years.⁦@HkuPharm⁩ ⁦@Ian_HKU⁩ link.springer.com/article/10.118…

P-CARDIAC secondary model's paper is finally out! A 10-year CVD risk prediction model for Chinese with established CVD risk. Go check out the article available on @escardio @ESC_Journals #EHJDigitalHealth #P_CARDIAC @hkumed @hku_son @HkuPharm doi.org/10.1093/ehjdh/…

Our study involving 3.6m mother-child pairs in @NatureMedicine suggests no direct causal relationship between gestational diabetes and ADHD. Instead, it highlights the importance of considering a holistic risk profile like shared genetic/familial factors. nature.com/articles/s4159…

Our recent study using CDM on @CambridgeCore finds immediate declines in mental health diagnoses following population-wide COVID-19 restrictions in France, Germany, Italy, UK, and US. doi.org/10.1017/S20457… #COVID19 #mentalillness @Ian_HKU @KennethKCMan @wallis_lau @HaoLuo429

Our study @NatureComms showed a progressive reduction in risk of clinical outcomes following COVID-19 infection and the effect of COVID-19 vaccination in reducing the risk and its persistence. nature.com/articles/s4146… #LongCovid #COVID19 @Ian_HKU @EricWan_HKU @Ranzhang_hku

My MMedSc/ RA supervisees @HkuPharm @hkumed @HKUniversity led and published our meta-analysis in Sleep Medicine Reviews (IF = 10.5; 11/212 in Clinical Neurology) showing increased fracture risks after sedative-hypnotic use: cautious prescription is needed! authors.elsevier.com/a/1i1Sw3tB5QxW…

Proud of Dr. @Yi_Chai18, Yuqi, and Rachel's excellent work on the potential inverse association of antipsychotic use with lung cancer, supervised by myself and Prof @Ian_HKU; findings now available in @CommsMedicine #drugrepurposing rdcu.be/dm3ig

Proud of Dawn, my former RA, who led this excellent review article as 1st author; we found that among #SSRI RCTs, many did not consider #multimorbidity in their sample adequately: real-world evidence is crucial in monitoring drug safety & effectiveness! sciencedirect.com/science/articl…