Ala Ali

In the setting of the alarming rise in worldwide disasters @ISNkidneycare @ASNKidney @ERAkidney are focusing on joint and impactful actions @ISNWCN #ISNWCN great talk by @Abualfaa from @AUB_Lebanon

Bacterial infection–associated glomerulonephritis in action 🔬🦠 Diffuse neutrophilic endocapillary proliferation, dominant C3 staining on IF, and classic subepithelial “hump-like” deposits on EM—hallmarks of infection-related GN. 💡 Key facts:
• Typically follows staph or strep infections (not just post-strep anymore)
• Often presents with AKI, hematuria, proteinuria
• Low complement (especially C3) is common
• IF: C3-dominant or co-dominant staining
• EM: subepithelial humps = immune complex deposition
• Can occur in adults with ongoing infection (not always “post”) Treat the infection → kidneys often follow.

Join GlomCon this Sunday The Podocytopathies: Current Concepts in Pathogenesis, guidelines, Novel therapies by Dr. Jai Radhakrishnan ID: 817 4374 4653 Passcode: 202122 Sign up 👉🏻 bit.ly/signup-glomcon #Glomcon

@fouadchebib @MayoClinicNeph @C_HannaMD @ndahl48 Congratulations

Proud to contribute to the new edition of Brenner and Rector’s The Kidney. Cystic kidney diseases remain a rapidly evolving space—this chapter brings together current biology, genetics, and clinical care in a field that continues to move forward. @C_HannaMD @ndahl48 @MayoClinicNeph Thank you @valerie_luyckx and @AlanYuNeph for your tremendous efforts in editing this book

The endothelium response to kidney injury dlvr.it/TRgL0H

Simple concept: Fibrinoid necrosis (necrotizing glomerulonephritis) versus Fibrin thrombi (thrombotic microangiopathy, TMA) 1. In fibrinoid necrosis, there is breach/rupture of the glomerular basement membrane (GBM), & fibrin is present in the Bowman’s space. Top panel. 2. In fibrin thrombi, the glomerular basement membrane is INTACT. There is No rupture of the GBM. Fibrin is present within glomerular capillary, and not in Bowman’s space. Bottom panel

@sjkdt_info @saudi_SSN Congratulations for the new Start. All the best

Upcoming issue

IgA nephropathy is the most common cause of immune-mediated glomerular disease worldwide. 📄 This Review summarizes the pathophysiology, epidemiology, clinical presentation, diagnosis, treatment, and prognosis of primary IgA nephropathy in adults. ja.ma/3NexRH9

🔔Don't miss tomorrow's webinar! Topic 👉 Management of Immunosuppression and Cancer Therapy in a Patient with a Kidney Transplant 🗣️Ala Ali, Itunu Owoyemi, Rachel Hellemans, Naoka Murakami 💡Learn IS strategies and challenges in patients on conventional chemotherapy, targeted therapies, and immunotherapies. 🗓️ Tuesday, March 3 at 9 am (ET) Join here 🔗 tinyurl.com/4rd3ts7s #TransplantTwitter #MedTwitter #Transplantation #TTS2026

Rare Disease And Nephrology Research Training (RADIANT) Program live session: Honored to host Dr. Brad Astor, who is teaching Fellows about Sample Size Estimation. Learn more about #GlomCon RADIANT Program here: glomcon.org/radiant-program #RADIANT #SampleSizeEstimation #SampleSize

For the first time @ISNWCN is organizing an onconephrology not to be missed with outstanding global speakers #ISNWCN privileged to have as co-chairs of this course @kdjhaveri @PepaSolerR

'Rare Kidney Diseases' is a peer-reviewed, #OpenAccess journal dedicated to advancing clinical and translational knowledge in glomerular, autoimmune, and genetic kidney diseases across all age groups. spklr.io/6010DYvHg @GlomCon @AKronbichler

🔔Don't miss this webinar! Topic 👉 Management of Immunosuppression and Cancer Therapy in a Patient with a Kidney Transplant 🗣️Ala Ali, Itunu Owoyemi, Rachel Hellemans, Naoka Murakami 💡Learn IS strategies and challenges in patients on conventional chemotherapy, targeted therapies, and immunotherapies. 🗓️ Tuesday, March 3 at 9 am (ET) Learn more 🔗 tinyurl.com/4rd3ts7s #TransplantTwitter #MedTwitter #Transplantation #TTS2026

Press release about atrasentan in IgA nephropathy (ALIGN trial). Very small effect size. novartis.com/news/media-rel…

Original Article: Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial (VISIONARY trial) nej.md/493Xtza Editorial: Targeting the Pathogenesis of IgA Nephropathy — A New Treatment Approach? nej.md/4too8hy #Nephrology #Immunology

Reference ranges for FLC ratios according to specific eGFR intervals, from Dr. @SabineKaram6 's lecture on Monoclonal Gammopathy of Renal Significance: Facts and Controversies. @GlomCon @glomconarabia

📰Thrilled to see Dr Jordan and Dr Karumanchi's new study in @NatureComms! "Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss" is available now. ➡️doi.org/10.1038/s41467…

📣 Attention nephrologists 👉Join us this Wednesday, 4 Feb for IPTA’s Kidney Community Call!📞 💡 We’ll explore current trends, exchange ideas, and spark new projects—driven by our collective expertise. Learn more 🔗tts.org/ipta-about/ipt… #medtwitter #transplanttwitter #pediatrics

Great lecture by Dr Mansour @mgh_transplant on neutrophils, our most abundant circulating immune cells. Rapid responders against diverse pathogens w/multiple killing mechanisms, yet they survive only 6–24 hours. Remarkably, ~50 billion are produced daily to keep levels steady.

Educational Webinars Series on Transplant Onconephrology; A collaboration between @ttsorg and @onconephsociety Click here to sign-up us02web.zoom.us/webinar/regist…