Alan Yu🇭🇰

short thread - or a story rather on the use of NAC (N-acetyl cysteine) and how it has lead us astray 1/

New Podcast: Drs. Morgan Gallazzini and Eloïse Marques discuss the results of their study, “Clustered Mitochondrial Homolog Inhibition by Lipocalin-2 Orchestrates Mitochondrial Disruption and Contributes to Kidney Disease” Listen here: kidney.pub/JPOD0961

This study explored how the extracellular matrix (ECM) remodels during acute kidney injury (AKI) and identified microfibrillar-associated protein 2 (Mfap2) as crucial for repair. Read more: kidney.pub/JASN0967 #BasicResearch

This #ASNJASN study explored the effects of losing the NUP93 gene in mice, which led to progressive kidney disease. Read more: kidney.pub/JASN0964 #BasicResearch

JASN Editors’ Choice 2025: GFR Measurement Using Transdermal Detection Methodology This study tested a new method for measuring kidney function using a fluorescent tracer: relmapirazin. Check out the paper here: kidney.pub/JASN0639

🔥Proud to share our latest #PKD prognostic model from CRISP IV In ADPKD pts with normal eGFR we can predict probability of kidney failure 15 years later with C-index >0.8 Uses only TKV + data obtained in usual clinical care @KUJGKI @KUMedCenter @fouadchebib

In this new #ASNJASN perspective live today, authors discuss a new model for NIH indirect costs that they developed: the FAIR model. Read more: kidney.pub/JASN1003

How Does Dietary Potassium Influence Blood Pressure? Check out this #ASNJASN Mechanisms of Kidney Disease article: kidney.pub/JASN0988

Major win in nephrology ! There is a steady and measurable decline in ESRD Congrats 🎈🍾 to scientist Pharma physicians and patients !

🔥KUMC EPIC is one of only 11 AHRQ-funded Evidence-based Practice Centers in the country. Director @Reem_A_Mustafa is an awesome mentor. What a great opportunity!

A new web-based tool called TraceOrg has been developed to accurately measure kidney, liver, and cyst volumes in patients with autosomal dominant polycystic kidney disease (ADPKD) using MRI scans. Read more in #ASNJASN: kidney.pub/JASN0904

.@KUMedCenter, @ChildrensMercy and @KUHospital have joined a national network of 46 institutions as designated NORD Rare Disease Centers of Excellence by the National Organization for Rare Disorders (@RareDiseases). Learn more: bit.ly/48upldK

The December issue of JASN is now available online! Topics covered this month include: - The HiLo RCT of Phosphate Targets during In-Center Hemodialysis - Kidney Transcriptomic Profiles in IgA Nephropathy - and more Check out the issue here: kidney.pub/JASN-1225 #ASNJASN Cover by Wu et al.

This #ASNJASN research explored how two transcription factors, Dmrt2 and Hmx2, influence the differentiation of intercalated cells in the kidney, which are crucial for acid-base balance. Read more: kidney.pub/JASN0885 #BasicScience

Honored to have #JuanCarlosVelez visiting @KUNeph @KUJGKI Fantastic lecture on #hepatorenal syndrome (of course)👏 Lots of practical recommendations backed up by research conducted by Dr. Velez at @OchsnerHealth

~15 years ago, Dr. Fred Coe put forward the “vas washdown” theory for explaining kidney stone formation Alan S.L. Yu @AlanYuNeph & team @KUMedCenter now report on a mouse model for kidney stone formation, showing kidney-specific claudin-2 deficiency leads to medullary nephrocalcinosis—and supporting the vas washdown model for Randall's plaque formation. doi.org/10.1172/JCI197… The figure shows 2D maps of calcium and sodium in midline coronal kidney sections of control (Cre–) and Cldn2 kidney-specific KO (Cre+) mice. Color scale represents concentration in ppm.

Nice editorial by @HumphreysLab highlighting our new @jclinicalinvest paper 🙏 jci.org/articles/view/…

Now out @jclinicalinvest led by #Christine_Behm with fantastic team of collaborators👇 We discover a corticomedullary gradient for Ca in kidney and show a critical role for claudin-2, with implications for kidney stone disease. @KUMedCenter @KUJGKI jci.org/articles/view/…

🔥 Kidney disease deserves all the attention! 👇 Chronic kidney disease: breaking the silence - The Lancet thelancet.com/journals/lance…

Distinct analysis populations map to different causal questions. This #ASNJASN Designing Clinical Trials article dives deep into the role of analysis populations and estimands in clinical trials. Read more: kidney.pub/JASN0970