Elana Pyfrom
62 posts

Elana Pyfrom
@ElanaPyfrom
Genetics PhD loading @CambUPenn | @amitaseh lab | @NSF GRFP Fellow | Brown alum 🐻 | a water enthusiast somewhere dreaming of lipids 👩🏿🔬







Honored to finally announce the best news I’ve gotten in my PhD so far- I have been awarded the NINDS F99/K00 D-SPAN!!!! My first fellowship(!) & first grant of many as I work towards starting my own lab investigating neural mechanisms of visceral pain. (Thread!!)

i am thrilled to announce that the Grmai Lab will open its doors Jan 2025 in the Department of Comparative Medicine @YaleSOM ! our lab will study the complex inter-organ signaling cues that influence metabolism and fertility during homeostasis and stress.






In this week’s Editors’ Choice piece, we highlight the work of Haynes and colleagues in @NatureNeuro, showing that glia detoxify neurotoxic lipids on a sleep-wake cycle, promoting healthy sleep. Read a summary: scim.ag/6Kw



Drosophila glia have a daily cycle of mitochondrial oxidation and lipid accumulation that is dependent on prior wake and requires APOE orthologs for neuron–glia lipid transfer. This may allow neurons to avoid accumulation of oxidative damage during wake nature.com/articles/s4159…





Our paper is finally out!! We found new roles of sleep + wake in processing the brain's lipid damage (see @paulahyns post!). I hope this work inspires a greater shift in Alzheimer's disease research towards the contributions of sleep and lipid transfer dysfunction






