Slava Epelman

Our latest study, led by @Homaira_H. Hard to study #macrophages (MFs) in early human heart development (no tissue). Homaira integrated human ES-derived-MFs into beating cardiac microtissues & improved🫀function. rdcu.be/dHbj0. #cardioimmunology #regeneration.

A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation #Fa" target="_blank" rel="nofollow noopener">science.org/doi/10.1126/sc…

How specific are therapeutic monoclonal antibodies, really? In our new paper, @Yile_Dai led a collaboration with Adimab to profile 174 FDA-approved and clinical-stage mAbs against 6,172 human extracellular proteins. What we found surprised us.🧵 sciencedirect.com/science/articl…

Caloric restriction in humans reveals immunometabolic regulators of health span | Science science.org/doi/10.1126/sc… Effects on thymus rejuvenation in humans (functional thymic vol and TRECs) were one of the unexpected finding from NIA funded CALERIE trial.

Big news: the thymus may be critical for adult health What if we missed something fundamental about the immune system? In two back-to-back papers in Nature, we show thymic health (AI on 30,000+ CT scans) links to longevity, disease risk & immunotherapy outcomes.

Precancers in the human pancreas. Imaged in 3D here using CODA. More here: nature.com/articles/s4158… About CODA: nature.com/articles/s4159…

New tool to trace mature neutrophils! By @lai9uan & co. x.com/i/status/20326…

Influenza virus hitches a cellular ride to the heart: Cell Host & Microbe cell.com/cell-host-micr…

@PeterPLiu_MD @Nature @HeartInstitute Congrats Peter and team, great study!

New study in @Nature CV Research: Our team at Ottawa @HeartInstitute discovered that bone-marrow derived cIAP2 drives damaging inflammation after a #HeartAttack. Blocking cIAP2 with newSmac mimetics, protects the heart and prevents #HeartFailure. rdcu.be/e8a2S

Thrilled to share: €1.3M from the Hector Foundation to study how cancer immunotherapies affect the heart. Together with partners at Heidelberg, DKFZ, MDC Berlin & Kiel, we’ll investigate ICI-associated atherosclerosis and early markers for safer therapy. klinikum.uni-heidelberg.de/newsroom/wie-k…

Gut microbes signal the brain influencing age-associated memory and cognitive function in the experimental model @arcinstitute @Nature nature.com/articles/s4158…

9/ During this study, we generated three new mouse strains and have deposited them at @jacksonlab for the community to use: 🐁 Mrc1-creERT2 (Strain #040118) 🐁 Lyve1-creERT2 (Strain #040119) 🐁 Csf1rΔFIRE on a congenic C57BL/6J background (Strain #041479)

Very excited to share our new work by the one and only ⁦@DuSiling⁩ on blood & skull BM derived cells replacing microglia || Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties - ScienceDirect sciencedirect.com/science/articl…

Thanks to a team at @UAlberta for today's #ArticleinPress, Neutrophil-derived Reactive Oxygen Species Mediate Doxorubicin-induced Cardiotoxicity and Skeletal Myopathy (Kasia Dzierlega et al.): ow.ly/HQaY50YrToI

Do we study the right biology after myocardial infarction (MI)? • Surgery in standard mouse model masks MI-specific immune responses • Minimally invasive model better reflects patient immune responses & reveals immature neutrophils worsen heart function tinyurl.com/MImodels

We are excited to share that our team's paper is published in Immunity: "Resident tissue macrophages maintain intraocular pressure homeostasis." This work grew out of a collaboration between glaucoma clinician-scientist Katy Liu MD PhD, glaucoma physiologist W. Daniel Stamer PhD, and immunologist Daniel Saban PhD, bringing together clinical, physiological, and immunological expertise to tackle a long-standing question: does the immune system directly regulate intraocular pressure? The answer is yes. authors.elsevier.com/a/1mkeB3qNrV3V… #Glaucoma #Immunology #ResidentMacrophages #Ophthalmology #Immunity #CellPress cell.com/immunity/fullt…

Just published @NatureMedicine A daily multivitamin (MVM) slowed epigenetic aging in a randomized trial after 2 years; effect was small (~2 months) and not seen with cocoa extract supplement (vitamin was Centrum Silver) nature.com/articles/s4159…

Will we give a shot of protective, self-amplifying RNA in patients with a heart attack in the future? @ScienceMagazine an intriguing innovation science.org/doi/10.1126/sc…

🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n] nature.com/articles/s4158…

Glad to share our work in #NatureImmunology showing that #fibroblast-#macrophage dialogue underpins of skin integrity. Big congrats to all the authors at #UofT and #Genentech for their tireless efforts. Looking for #PDs to continue this work~ rdcu.be/e50PJ