Siling Du

Very thrilled and grateful to see our work featured on the cover of @NeuroCellPress! Many thanks to our co-authors and collaborators who contributed to this study.

cell.com/issue/S0896-62… On the cover: In this issue of Neuron, Du et al. @DuSiling show that repeated microglial depletion enables peripheral monocytes from both the blood and skull bone marrow to infiltrate the brain and engraft as monocyte-derived macrophages with distinct identities. Inspired by a passage from the Zuo Zhuan (“The first beat of the drum rouses the soldiers’ spirits; the second weakens their resolve; by the third, they are exhausted”), the artwork depicts three rounds of microglial depletion gradually exhausting the endogenous microglial niche. The two advancing armies represent distinct peripheral sources of invading cells: one arriving from the blood, illustrated by the army bearing the red flag, and the other emerging from the skull bone marrow, portrayed as descending from the mountains. Artist credit: Ying Xu.

Check out our recent work on @NatureComms! Greatly appreciate my mentors and collaborators making this possible. We developed epi-Patho-DBiT, a unified platform that enables spatially resolved ATAC -seq or CUT&Tag analyses in FFPE tissues!

OBS Immunology Immune cell ontogeny, and functional specialization of immune cells 🔹Laura Jiménez Gracia, PhD @cnag_eu 🔹Jing Chen @Jingneticist @washumedicine Moderator: @asalboix 📅 Tuesday, April 14 ⏰ 12 pm ET, 6 pm CET 💻 us02web.zoom.us/meeting/regist…