A/Prof Lee-anne Chapple

Post Intensive Care Syndrome Edited by amazing Brad Butcher! Thank you for leading many champions of ICU rehab to this outstanding achievement! cambridge.org/core/books/pos…

Our international and interprofessional perspective paper on the ICUAW research agenda has been published in #ICM. Fantastic collaboration! Fulltext: rdcu.be/eOaZY

🔥 HOT DEBATE at #lives2025 organized by The FREM section on ICU nutrition ➡️EN vs. PN:"EN first" & sPN to prevent underfeeding? ➡️Timing: How do we practically evaluate anabolic & metabolic readines ➡️Risks of Delay: What are the costs of underfeeding vs. dangers of forcing nur

En route to beautiful Prague for the European Society of Clinical Nutrition and Metabolism Congress. Excited to share the results of our TARGET Protein Trial on Tuesday 8:30am and seeing lots of familiar faces. If we haven’t met, come say hi! 👋🏻

Career highlight! Honoured to present @ProteinTarget with @msummo2 at @CritCareReviews in Belfast. You can read all about the trial in JAMA: jamanetwork.com/journals/jama/… Or watch the full recording at: criticalcarereviews.com

Great way to end a busy fortnight of conferences!

A glorious Summer's day on the Giants Causeway..... #CCR25 Faculty Day Out

@celiabradford We used Nutrison Protein Plus in the usual care arm as this was the most common product used in our region. The impact of an even lower protein dose is unclear without trials that explore this, however I would be concerned about the impact of this on muscle mass/function.

#targetprotein if the control group is receiving proton plus feeds, is it possible that regular nutrision would in fact be superior to your ‘control’ group

Augmenting enteral protein did not improve outcomes for critically ill patients compared with standard protein levels in the intensive care setting. #CCR25 @CritCareReviews ja.ma/45jf3NI

3. Lower protein doses (1.2g protein/kg/day) increased to goal over the first 4 days of ICU should be considered. 4. Future work may target the time to ⬆️ protein doses, given the impact of lower protein dose on muscle mass/malnutrition, potentially guided by urea levels.

My interpretation: 1. Short-term early higher dose protein feeding does not impact outcomes in critically ill patients. 2. Caution should be taken particularly for patients with an AKI at baseline.

@ProteinTarget results presented today at #CCR25 and published in @JAMA_current: jamanetwork.com/journals/jama/… My takeaways: 🧵

Meta-analysis mentioned in the @ProteinTarget editorial- shows harm in sub-group. Also shows signal for improved physical outcomes #citeas" target="_blank" rel="nofollow noopener">ccforum.biomedcentral.com/articles/10.11… #ccr25

Seminal work by @LSChapple and team mentioned in the @ProteinTarget editorial #ccr25 Muscle Protein Synthesis after Protein Administration in Critical Illness | American Journal of Respiratory and Critical Care Medicine atsjournals.org/doi/10.1164/rc…

Such a pleasure to present the @ProteinTarget trial at this incredible venue.