NedergaardLab

Yesterday we celebrated the yearly #CTN day @ucph_health with stimulating scientific interaction and fun games🥎 in #Fælledparken🌳 in ☀️sunny😎 #Copenhagen. #science #neuroscience #retreat #teamwork #PhDlife #brain #glymphaticsrulez #sleep #tugofwar #labday @MaiNedergaard

Check out our new review about the role of glymphatic transport in ocular diseases. doi.org/10.1016/j.pret…

The Kaag Rasmussen lab at the Center for Translational Neuromedicine is looking for a highly motivated postdoc candidate to study CSF and extracellular signaling pathways in migraine. The role includes proteomics, transcriptomics, behavior, and in vivo imaging. APPLY below (MKG)

Vittani, Lee, Wang, Hiraoka, et al. KI mouse expressing red fluorescent blood In situ SpyTag/Catcher attachment of biosensor ECS SpyCatcher to capture BBB leak doi.org/10.1101/2025.0… We hope this method is useful to a wide range of the biology community.

Out today in @CellCellPress ! We show that oscillations in norepinephrine and cerebral blood volume are the missing pieces that link NREM sleep to clearance of waste from the brain 🧠💤 cell.com/cell/fulltext/…

12 Months of #Neuroscience March 2024 We can now see oxygen in the brain! It is already providing insight into why a sedentary lifestyle risk for diseases like #Alzheimers this #URochesterResearch method via @NedergaardLab made the discovery using a protein similar to what gives a firefly its glow. @ScienceMagazine 👉 science.org/doi/10.1126/sc…

Reach out to us if you have further questions regarding the method. We are happy to help you!

How can understanding brain waste flow inform brain health? Prof Douglas Kelley, PhD, of Mechanical Engineering @UofR Hajim, aims to understand the glymphatic system so conditions like #Alzheimer's and #Parkinson's can be studied more effectively. #URochesterResearch In a Neuro Minute🧠

1/4 We are thrilled to announce that our 🌍 collaboration has resulted in a paper in @_JCBFM. @Gazz4_Science @CathFoster_ @BradASutherland @UTAS_ @SeattleChildrens @uni_copenhagen doi.org/10.1177/027167…

Virally Induced CRISPR/Cas9-Based Knock-In of Fluorescent Albumin Allows Long-Term Visualization of Cerebral Circulation in Infant and Adult Mice link.springer.com/protocol/10.10…| Marta Vittani, Philip Aleksander Gade Knak, Masahiro Fukuda, Masaki Nagao, Xiaowen Wang, et al.

2 years of postdoctoral fellowship in Translational Neuroscience completed today. Grateful for the opportunity @UCPH_BRIDGE & @novonordiskfond. I thank my excellent mentors, Prof. @MaiNedergaard & Prof. @MessoudAshina @NedergaardLab @hmru_cph @UCPH_health #migraine

Why sleep is important! biorxiv.org/content/10.110…

Oxygen sensor for in vivo expression available now on Addgene: AAV vector expressing GFAP-GeNL addgene.org/221455/ @NedergaardLab

New cool data on the impact of aging on cervical lymphatic vessels in @NatureAging – and how a prostaglandin can restore function. nature.com/articles/s4358…

Online now! Cervical lymphatics drain CSF and clear metabolic waste from the brain. Du et al., show using 2P-OPTIC that these are disrupted in aging due to reduced pumping. Restoring cervical lymphatic function with PGF2a rescues brain clearance. doi.org/10.1038/s43587…

Beautiful paper from @NedergaardLab in @NatureAging on the role of cervical lymphatics in cleansing of aged brain. Glymphatics/meningeal lymphatics = bff 🤩|| nature.com/articles/s4358…

#URochesterResearch via @NatureAging shows how scientists restored the brain’s ability to clear toxic waste in older mice with a drug that's currently used to induce labor. This points to a potential new treatment for #Alzheimers and #Parkinsons. Paper: go.nature.com/46WCR8F 👇Watch the aging lymphatic system – less contractions in the older mouse (right) causing the waste to stop and flow in different directions.

Really nice review discussing the anatomical and functional evidence for the SLYM layer. anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar…

Our latest paper from the Lilius lab is now out in @_Anesthesiology! doi.org/10.1097/ALN.00… I'm happy to have been able to co-first author this paper together with @LohelaT under the supervision of @tlilius! In collaboration with people from the @NedergaardLab

A new Science study in mice identifies a novel non-synaptic signaling mechanism between the brain and peripheral sensory system important for migraine. Learn more ⬇️ 📄: scim.ag/7D5 #SciencePerspective: scim.ag/7D4