Nature Aging

🗞️Our July issue is live!✨Read about IL-11 as a target in ovarian aging, circulating metabolites connecting exposures to brain health, the effects of exercise on the aged human muscle multi-ome & much more nature.com/nataging/volum…

Online now!✨Mu, Barthez, Feng, Chen, Wang et al report that trained immunity links hematopoietic stem cell aging to age-associated inflammation nature.com/articles/s4358…

📎 and read the Research Briefing here: nature.com/articles/s4358…

Online now!✨RESEARCH: Carver et al profile the aged mouse brain using spatial transcriptomic and imaging analysis, identifying a senescence- and disease-associated microglial-linked state nature.com/articles/s4358…

1/ What if some of the consequences of #aging are not caused by damage itself, but by the alarm signals our cells generate in response to that #damage? Today, we publish a study in @NatureAging addressing this question. nature.com/articles/s4358…

Online now!✨Oppezzo et al therapeutically block telomeric DNA damage signalling to restore hematopoietic function in telomerase-deficient and aged mice, while reducing senescence and inflammation @FdAdF66 @IFOMresearch nature.com/articles/s4358…

Online now! ✨Abdellatif, Kim and Kroemer propose a pragmatic approach for the clinical evaluation of geroprotective interventions nature.com/articles/s4358…

We are excited to share our🚨latest work🚨in @NatureAging: “Epigenetic clocks as quantitative readouts of epigenetic drift”! We revisit the history of epigenetic drift, from early observations to current views on how the epigenome evolves during lifetime. nature.com/articles/s4358…

🗞️Our June issue is live!✨Read about the healthspan and lifespan effects of time-restricted feeding in mice, insights from mathematical models of aging, how R-loops drive the SASP, & much more nature.com/nataging/volum…

Online now!✨Hao et al report that R-loops activate cGAS-STING to drive the SASP. Inhibiting XPO1 to block R-loop nuclear export reduces inflammaging nature.com/articles/s4358…

📎And now, read the associated Research Briefing here: nature.com/articles/s4358…

Online now!✨Raz et al fit survival data across species to a stochastic model of damage accumulation and removal; damage production rate best predicts lifespan, and species fall into two distinct aging regimes @UriAlonWeizmann @WeizmannScience nature.com/articles/s4358…

📎And now, read the linked News & Views by Timothy Chang & Mimi Shirasu-Hiza here: nature.com/articles/s4358…

Online now!✨Iiams, Skinner et al explore the effect of early-onset, lifelong time-restricted feeding in >500 male and female mice, and report extended healthspan in male and female mice, and extended lifespan in male mice @SamIiamsClever @CircadianClocks nature.com/articles/s4358…

Online now!✨RESEARCH: @zanehkoch et al infer activity of the DNA repair-repressing DREAM complex via reduced expression of its repressed targets, and use DREAM knockout mice, to link DREAM activity to somatic mutation, disease and lifespan @TreyIdeker nature.com/articles/s4358…

Online now!✨In a perspective, Zalesky, Wen and Tian discuss the evolution of aging clocks into organ-specific aging readouts based on omics and imaging data, highlighting differential aging across organs, within interconnected systems nature.com/articles/s4358…

Online now! ✨Using C. elegans, @arpit_science et al link age-associated decline in peroxisomal function to metabolic inflexibility nature.com/articles/s4358…

On the cover🎨: Pan and colleagues explore the role of ULK1 in neurodegeneration

🗞️Our May issue is live!✨Read about immune mechanisms of calorie restriction identified from clinical trial data, tools to detect senescence burden via urine samples, asynchronous aging across female reproductive organs & much more nature.com/nataging/volum…

Online now!✨Crofts et al report a parsimonious model of stem cell dynamics describing how diverse DNA methylation patterns emerge during aging nature.com/articles/s4358…