Nature Aging

🗞️Our April issue is live! ✨the cover art depicts work on macrophage senescence as postage stamps 🎨 the issue includes studies on improving vaccine efficacy in aging, endogenous regulation of cGAS, repurposing drugs for vascular dementia & much more nature.com/nataging/volum…

@mele_lab, @marta_mele_m, @BSC_CNS

Online now! ✨Soldatkina, Ventura-San Pedro et al apply deep learning to histological and transcriptomic data from female reproductive organs across ages, reporting distinct and asynchronous aging trajectories detectable in independent plasma proteomics nature.com/articles/s4358…

Online now!✨Founded by the Dutch, German, Nordic and British aging research societies, the European Federation for Aging Research (EFAR) has been launched to bring together aging researchers across Europe nature.com/articles/s4358…

@MicrobioUCLA @UCLAStemCell @UCLAHealth @DGSOMUCLA

Online now!✨RESEARCH: Salladay-Perez and colleagues interrogate whether macrophages can really undergo senescence, and characterize a p21+Trem2+ senescent macrophage population functionally implicated in inflammaging and liver disease @ACovarrubiasPhD nature.com/articles/s4358…

@YaleAge @yalepathology @YaleMed

Online now!✨Mining the longitudinal plasma proteome of CALERIE participants, @MishraManish29, @Hee_Hoon_Kim et al link C3a to inflammaging. In aged mice, visceral fat macrophages produce C3a and neutralizing it blocks inflammaging @VishwaDeepDixi1 nature.com/articles/s4358…

And read the associated Research Briefing here: nature.com/articles/s4358…

Online now! ✨Sopena-Rios, Ripoll-Cladellas use single cell transcriptomic data from nearly 1,000 female and male participants across the adult lifespan to profile sex-specific immune aging dynamics @mele_lab, @marta_mele_m, @mariasopenarios, @BSC_CNS nature.com/articles/s4358…

Online now!✨RESEARCH: extracellular vesicles from senescent hepatocytes carry miRNAs which enhance metastatic potential in tumor-bearing aged mice, and which are enriched in tumors from older patients nature.com/articles/s4358…

Humanity is traveling further into #space. Here, just published in @NatureAging , we discuss parallels between #spaceflight and #aging. @Furman_Lab @BuckInstitute @UHN rdcu.be/fbymi nature.com/articles/s4358…

🗞️Our March issue is live, with killifish artwork by @dariovalenzano_ on the cover!🎨Read work on senescence in mammary gland remodelling, structural protein changes as readouts of Alzheimer’s disease, the 201 Parkinson’s disease trial & more ✨nature.com/nataging/volum…

Online now! ✨Quarta et al present the Senotherapeutics Biomarker Consortium, a framework to accelerate translation of senescence research into clinically meaningful therapies nature.com/articles/s4358…

Online now! ✨Schmauck-Medina et al review dietary restriction as a class of geroprotective interventions across species, considering conflicting data, mechanisms, mimetics and side effects @TheFangGroupUiO nature.com/articles/s4358…

Online now!✨Lin, Shao, Shi et al identify a mechanism by which swimming exercise attenuates cognitive decline in Alzheimer's disease mice. Skeletal muscle-derived vesicles act as myokines, regulating lipid metabolism and plaque clearance in microglia nature.com/articles/s4358…

📎 And see the News & Views by Erlin Wang & Jianxiong Zeng here: nature.com/articles/s4358…

Online now!✨Song et al identify the glycolytic metabolite PEP as an endogenous inhibitor of cGAS-STING, and an adaptive response during aging. PEP levels correlate with healthy traits in humans and PEP supplementation promotes healthy aging in mice nature.com/articles/s4358…

Online now!✨RESEARCH: Chen, @VarunDw et al present EMRAge and OMICmAge: biological age measures which integrate electronic medical records, multi-omics and DNA methylation, strongly associated with disease and mortality across validation cohorts nature.com/articles/s4358…

📎Now read the News & Views "Senescence at the crossroads of postpartum remodeling and tumorigenesis" from Victoria Findlay here: nature.com/articles/s4358…