Nature Aging

🗞️Our February issue is live! Read work on precision responses to therapy-induced senescence, senolytic resistance mechanisms, AD biomarkers in Latin America, the exposure of older adults to health misinformation, links from DNA damage in macrophages to autoimmunity & more ✨

Online now! ✨Quarta et al present the Senotherapeutics Biomarker Consortium, a framework to accelerate translation of senescence research into clinically meaningful therapies nature.com/articles/s4358…

Online now! ✨Schmauck-Medina et al review dietary restriction as a class of geroprotective interventions across species, considering conflicting data, mechanisms, mimetics and side effects @TheFangGroupUiO nature.com/articles/s4358…

Online now!✨Lin, Shao, Shi et al identify a mechanism by which swimming exercise attenuates cognitive decline in Alzheimer's disease mice. Skeletal muscle-derived vesicles act as myokines, regulating lipid metabolism and plaque clearance in microglia nature.com/articles/s4358…

📎 And see the News & Views by Erlin Wang & Jianxiong Zeng here: nature.com/articles/s4358…

Online now!✨Song et al identify the glycolytic metabolite PEP as an endogenous inhibitor of cGAS-STING, and an adaptive response during aging. PEP levels correlate with healthy traits in humans and PEP supplementation promotes healthy aging in mice nature.com/articles/s4358…

Online now!✨RESEARCH: Chen, @VarunDw et al present EMRAge and OMICmAge: biological age measures which integrate electronic medical records, multi-omics and DNA methylation, strongly associated with disease and mortality across validation cohorts nature.com/articles/s4358…

📎Now read the News & Views "Senescence at the crossroads of postpartum remodeling and tumorigenesis" from Victoria Findlay here: nature.com/articles/s4358…

Online now!✨RESEARCH: Dai et al implicate defective dendritic cell migration in impaired vaccination responses in aged mice. Treatment with yeast-derived nanoparticles stimulates DC migration and restores vaccine efficacy nature.com/articles/s4358…

📸On the cover: the Chinese hero archer Hou Yi, who, according to legend, saved the Earth from scorching heat, is depicted as quenching inflammation

🗞️Our February issue is live! Read work on precision responses to therapy-induced senescence, senolytic resistance mechanisms, AD biomarkers in Latin America, the exposure of older adults to health misinformation, links from DNA damage in macrophages to autoimmunity & more ✨

Online now! ✨Chiche, Djoual, Charifou et al identify a dual role for senescence in postpartum tissue remodelling: senescent cells drive mammary gland involution, yet predispose to postpartum tumor initiation @HanLi_Pasteur nature.com/articles/s4358…

Why do some neuron types degenerate early while others stay intact? We used transcriptomic aging clocks for single-neuron-types in C. elegans and found neuron-specific biological age predicts vulnerability. @NatureAging nature.com/articles/s4358… #Neurodegeneration 🧵👇 (1/n)

Damaged cells may help lung and ovarian cancers resist chemotherapy, but targeting them could improve cancer treatments. Researchers from @MunozEspin_Lab at the @EarlyCancerCam and Brenton & Narita Groups at @CRUK_CI report the findings in @NatureAging. cruk.cam.ac.uk/news/targeting…

📎 And see the News & Views by Saima Hassan & Gerardo Ferbeyre: nature.com/articles/s4358…

Online now!✨RESEARCH: González-Gualda, Reinius et al identify TGFβ ligands in the platinum chemotherapy-induced SASP as drivers of tumor progression in lung and ovarian cancer, pairing mouse models with clinical validation @MunozEspin_Lab @DanielMuozEspn1

Focus on Roundtables at #ICFSR26! 🧬 Biomarkers of Aging discussion with: Sébastien Thuault (@NatureAging ) @Ferruccilu (NIA) Peggy Cawthon (@UCSF ) David Furman (@BuckInstitute ) @Danbelsky (@ColumbiaMSPH ) How do we measure biological age? Join the conversation. #AgingResearch #Geroscience

Online now! ✨In a comment, Lopes de Oliveira et al highlight how epidemiological approaches can be used to improve the development of biomarkers of aging @HaggSara nature.com/articles/s4358…

Online now!✨RESEARCH: Wakita et al systematically compare the efficacy of 21 senolytics across models, and identify a subpopulation of senolytic-resistant cells, vulnerable to mitochondrial interventions @Biken_RIMD_jp nature.com/articles/s4358…

📸On the cover: a cloth woven from multicolored threads, in which the roman numeral V emerges, represents the journal’s vision of bringing together aging research from different corners of the field

🗞️In our January issue, we celebrate the 5th anniversary of Nature Aging 🎉Read one Q&A from aging researchers, another Q&A to peek behind the scenes at the journal, our reflections on the past 5 years, and lots of great science too, here: nature.com/nataging/volum…