Shiekhattar Lab retweeté
Nature research paper: RNA N-glycosylation enables immune evasion and homeostatic efferocytosis
go.nature.com/4m6slCP
English
Shiekhattar Lab
427 posts
Shiekhattar Lab
@ShiekhattarLab
@SylvesterCancer @Univmiami
Miami, FL Inscrit le Mart 2018
230 Abonnements561 Abonnés
Shiekhattar Lab retweeté
For a quick summary, read the Research Briefing here:
nature.com/articles/s4159…
English
Shiekhattar Lab retweeté
Our new paper is out on @MolecularCell !!
We show that Integrator complex, is essential for RNA Polymerase II recruitment, pluripotency, and developmental gene regulation in mESCs.
sciencedirect.com/science/articl…
#StemCells #Transcription #DevelopmentalBiology #RNApolII
English
Sylvester Comprehensive Cancer Center@SylvesterCancer
🔬 Science meets leadership. As director of Sylvester, @DrSDNimer leads a powerful network of researchers, physicians and patients while continuing his own work in the lab. In his latest study, Dr. Nimer and colleagues uncovered how a key molecule, TAF1, regulates hematopoiesis. Their discovery opens the door to potential new therapies targeting TAF1. ➡️ The findings were published July 16 in @Dev_Cell. Read more: loom.ly/Y9EjgjU
English
We also uncover a key role for INTS11 in neurodevelopmental gene regulation.
English
We introduce rPRO-seq, a rapid and low-input method to map nascent RNA with nucleotide precision — in just 12 hours and from as few as 5,000 cells.
sciencedirect.com/science/articl…
#RNA #Genomics #PROseq #NascentTranscription #Neurodevelopment #MolecularCell
English
Shiekhattar Lab retweeté
Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks biorxiv.org/cgi/content/sh… #biorxiv_molbio
English
Explore emerging #CancerEpigenetics #CancerTherapy #Epigenomics research with field leaders @KeystoneSymp Epigenetic Mechanisms and Cancer Treatment, this February in Santa Fe! keysym.us/KSCancerEpi24 #KSCancerEpi24
English
Hello, check our new paper in BioRxiv. It describes new integrator module (INTS9/INTS11 and BRAT1) regulating the neurodevelopment program.
bioRxiv@biorxivpreprint
BRAT1 associates with INTS11/INTS9 heterodimer to regulate key neurodevelopmental genes biorxiv.org/cgi/content/sh… #bioRxiv
English
Shiekhattar Lab retweeté
Join us for a FUSION Conference on "Genome Regulation through RNA" next February (11-14) in Cancun!
fusion-conferences.com/conference/155
The meeting will boast cutting-edge work on #epigenomics, #transcription, #lncRNAs & #smallRNAs biology, #genomeintegrity, #epitranscriptomics and more!
(1)
English
Shiekhattar Lab retweeté
What can machine learning do for your favorite protein complex? A lot! Especially if paired with proteomics and genomics. In collaboration with @WojtekGalej we characterized the 15th Integrator subunit! Shout out to @offley_sarah and @MorPfl for leading this effort #transcription
Cell Reports@CellReports
A combinatorial approach to uncover an additional Integrator subunit dlvr.it/SktD5q
English
Shiekhattar Lab retweeté
Interestingly they show H3K4me3 is required to recruit integrator complex, which is essential for the eviction of paused RNAPII and transcriptional elongation.
Lluis Morey@lluismorey
What is the precise role of H3K4me3 in transcriptional regulation? Check out this very interesting new paper from @HelinLab in @Nature nature.com/articles/s4158…
English
Shiekhattar Lab retweeté
Human Integrator provides a quality checkpoint during elongation to facilitate RNA polymerase II processivity biorxiv.org/cgi/content/sh… #bioRxiv
English
Our new paper is out on @ScienceAdvances The Integrator complex regulates microRNA abundance through RISC loading science.org/doi/10.1126/sc…
Well done @kirstein_nina and @SaDo47654137 and all collaborators.
English
Shiekhattar Lab retweeté
Kicking off day 2 with Polycomb & noncoding RNA in cancer, at the 5th Biennial Miami Cancer and Epigenetics Symposium🧬 #MiamiEpigenetics2022 @SylvesterCancer @AsifaAkhtar1 @GardiniLab @harvardmed @ShiekhattarLab
English
Shiekhattar Lab retweeté
#MiamiEpigenetics22 Great opportunities for learning and connecting. Many thanks to the organizers @SylvesterCancer and the world renowned speakers 👏👏 😊😊
English
Shiekhattar Lab retweeté
We had a great turnout this weekend at the 5th Biennial Miami Epigenetics and #Cancer Symposium with engaging talks from speakers representing the top #cancer #research institutions in the nation and internationally. #MiamiEpigenetics2022
English
Shiekhattar Lab retweeté
Thrilled that so many experts came to @SylvesterCancer symposium to discuss their most promising and recent research findings AND brainstorm to establish collaborations and help the trainees advance their science and career!
Sylvester Comprehensive Cancer Center@SylvesterCancer
We had a great turnout this weekend at the 5th Biennial Miami Epigenetics and #Cancer Symposium with engaging talks from speakers representing the top #cancer #research institutions in the nation and internationally. #MiamiEpigenetics2022
English
Shiekhattar Lab retweeté
Impactful symposium in Miami this weekend! Some of our very own @ShiekhattarLab, @lluismorey, @thecimminolab and @TaylorJ_MD discussing the latest discoveries in cancer and epigenetics research. @SylvesterCancer #MiamiEpigenetics2022
English