Xia Yang Lab UCLA

Highlight of our new study on the comparison of gene networks between common and rare variants of autism! scienmag.com/autism-genes-c… Thanks to the team for the amazing collaborative work and thanks to Cameron Gill for the strong leadership!

Congratulations to Dr. David Ulmert @davidulmert and team for the promising new LRRC15-targeting radionuclide therapy for aggressive, treatment-resistant tumors! uclahealth.org/news/release/s…

Excited to share our latest work in @CellReports highlighting a PPARγ-dependent remodeling of translation machinery in adipose progenitors. Amazing collab between our lab @ClaudioVillanu @YangLabUCLA and @LauraHulea @CellPressNews @uclaibp cell.com/cell-reports/f…

The paradoxical effects of fish oil on cardiovascular risk shown in doi.org/10.1136/bmjmed… reminds me of our similar findings on DHA on brain transcriptome/epigenome/cognition/metabolism - it compromises or protects depending on health or disease state: doi.org/10.1002/mnfr.2…

Want to hear about the latest updates/new techniques in single cell and spatial genomics? Check out the full agenda for our Single Cell Genomics Day on Friday, 3/29. All talks will be live-streamed (no registration required) at satijalab.org/scgd

Free Cell Press webinar, Lessons from multiomic & transcriptional analyses in cancer & complex disease w/ speakers Anna Seung Nam @AnnaEnim @WeillCornell, Elisa Oricchio @elisa_oricchio @EPFL & Xia Yang @UCLA @YangLabUCLA. March 13, 12:00 pm ET. hubs.li/Q02mxJPT0

The scientist who persevered—despite all these challenges and many more—to transform medicine ✓ Threatened to be deported ✓ Demoted ✓ Dismissed ✓ Grants systematically rejected ✓ Seminal paper rejected by leading journals

We are thankful for this Insight preview article by Dr. Arya Mani from Yale: “Genetics: From mouse to human” doi.org/10.7554/eLife.… about our new eLife article: elifesciences.org/articles/88266!

Matt Damon makes a better case for academic tenure than I’ve ever heard twitter.com/docnoir_/statu…

Our new study is out in @eLife: “Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse” doi.org/10.7554/eLife.… Thanks to the team led by @zeynebkurt @MontyBlencowe and collaborators Drs. Jake Lusis and @JohanBjorkegren!

This is unbelievable! Kurt Wüthrich, an 84-year-old, Swiss, male scientist, who won the Nobel Prize in 2002 claims that "as a male scientist" he has "a feeling of discrimination." He said this during the 72nd Lindau Nobel Laureate Meeting on a panel that had four old, male scientists including him and an old, male moderator. (It was literally a susage fest!) When Science Magazine asked him to elaborate on the kind of discrimnation he faced, "Wüthrich said he did not feel personally discriminated against as an individual at the event but thought that all men attendees faced discrimination while women were tokenized." Here's an example of the discrimination Kurt Wüthrich, a Nobel Prize winner, gave: In group photos of laureates, women laureates were asked to stand in front while male scientists like him were told to stand behind them 🤦😂😭 This makes him feel "horrible" because asking women laureates to stand in front is "ridiculous, fully ridiculuous." A young scholar countered Wüthrich's childish tantrum and the moderator tried to shut her up. For reference, here's a comparison: Nobel Prizes won: By men: 892 By women: 60 Speakers invited to this year's Lindau meeting: Men: 34 Women: 5 ------ A couple of observations: 1. The feeling among men that gender equality is somehow a form of discrimination against them is not limited to incels (involuntary celibates) on the internet. Male Nobel Prize winners can feel the same way too. 2. Many young scholars and scientists are still playing the "prestige" game: do a PhD in a "prestigious" university, do a postdoc in a "prestigious" lab, go to "prestigious" meetings like Lindau. Playing the prestige game takes a lot of toll on one's mental health and personal relationships. The worst part is make you feel extremely insecure. No amount of external validation, not even a Nobel Prize, will help you overcome your insecurities.

Our SCING method for gene regulatory network (GRN) modeling for scRNAseq and spatial transcriptomics is formally published. Congratulations to @littman_russell, Michael Cheng, Ning Wang, and @ChaoPeng19. Hope this is useful for your research! cell.com/iscience/pdf/S…

A third of people are Blood Group A. #SARSCoV2 preferentially infects these cells "providing a direct link between ABO blood group expression and [Covid] infection" ashpublications.org/blood/article/… @ASH_hematology

Congrats to all our lab graduates: Dr. Jessica Ding @jaliyahding, Dr. Gaoyan Li, MS Lorin Kirmizi, undergrads Kavya Immadisetty, Ashwathi Nair, Ormina Naveed, Darren Wijaya, Carissa Zhu! It’s a privilege to work with all of you. We are proud of you and wishing you all the best!

All is welcome to join Jessica’s PhD defense on June 14 at 11am in Boyer 159 to celebrate her journey and learn about her multiomics tools and application studies linking metabolic modulation to Alzheimer’s disease!

Please join Gaoyan’s PhD defense today (Monday, June 12) at 1:30pm in BSRB Room154 to help us celebrate her achievements and hear about her single cell studies of the hypothalamus and white adipose tissue dynamics which influences a broad range of health conditions.

Please join me at the Multiomics in Precision Medicine Conference at UPENN!  Seating is limited.  Use the code TAKE25 to receive a discount.  Hope to see you there!  Register here web.cvent.com/event/7d60d045…

Read our latest #research on finding new ways to 🥷 ⛔️#inflammation in #atherosclerosis using #drugrepurposing #systemsimmunology #CyTOF published on @NatureCVR rdcu.be/dd4Ne @nyugrossman @NYULHCVRC @nyulangone @GiannarelliL @NIH @ncats_nih_gov 🧵👇

@Allard_Lab_UCLA Congratulations, Patrick! So well-deserved!!

From a kid who grew up in rural France and fell in love with biology when looking at onion cells under the microscope to learning today that I will be promoted to Full Professor at UCLA on July 1st! What a long, tortuous, but exciting journey. (Also, I feel old!).

Delivery of therapeutic molecules is a major bottleneck for treating a wide range of diseases. Today we describe a new modality for delivering proteins based on an engineered contractile injection system @nature nature.com/articles/s4158…