Scientek

@NaOHBartfield 🥼🧪 = 😎 Going to start making model NFTs of my #aptamers and rocking it out on a t-shirt

They had a PD-1 binder shirt at uniqlo Kyoto (??????)

Ready to 🚀

@jpsenescence Been there… and then you are looking through the history but can’t remember what it is called… then three years later you find it and read it and it was the worst paper you ever read.

Just closed a tab with a paper I wanted to read 3 years ago

High-Throughput Multiplexed Quantification of Molecules by Aptamer Sequencing (Apt-seq) in Single Cells | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Phototriggered LYTAC: Photoactive Bispecific Aptamer Chimera Enhances Targeted Degradation of Membrane Protein through Regulating Cell Autophagy | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Thank you again to @AptamerSociety for another fantastic meeting! I learned a lot, made new connections and got fantastic insights and support from the experts in the field! Looking forward to getting back into the lab (and computer) so I have something to show for next year.

@anadfdez Going to read!

🥳Big thanks to everyone who made our first Special Issue a success. 🚀Now it's time for the 2nd Edition. Looking forward to more great contributions from the community. mdpi.com/journal/biosen…

@AptamerSociety Conference we will show a little of our platform Aptamize aptamize.com over 🍻

I am honored to speak @LPMHealthcare Aptamer Conference on March 24th 2026. I will be talking about AI, magic and how one can develop a novel aptasensor using in silico techniques as a starting point. libpubmedia.co.uk/aptamers-2026/…

We helped develop a sensor using our in silico pipeline. See more here: pubs.acs.org/doi/full/10.10…

Need an aptamer to make a novel drug diagnostic? We developed Aptamize. 1. Find and characterize aptamers in silico with Aptamize in seconds 2. test in vitro 3. put it on a LFA/Electrochemical strip 4. sell aptamize.com

If you need some biophysical characterization on your proteins or nucleic acids structures.... these guys are awesome. bimovis.com/structure-dete…

A new mechanism for “RNA memory”! 😱 Thrilled to share another crazy paper from the lab (can’t believe we posted 2 in 2 days!), summarizing >10 years of research: Work on transgenerational inheritance of small RNAs in the powerful model organism C. elegans changed how we think about what’s possible in inheritance and evolution, because it allows the most heretical thing: inheritance of parental responses to the environment! However, it’s still unclear whether RNAs are inherited across generations in other animals, largely because the RNA-dependent RNA polymerases that amplify heritable small RNAs and prevent their dilution in C. elegans are not conserved in mammals. In this new work, an amazing collaboration with the Rink and Wurtzel labs, we show that planarians establish long-lasting and heritable small RNA–based gene regulatory states despite lacking canonical RNA-dependent RNA polymerases and nuclear RNAi machinery (that are required in C. elegans). You might say “they are both worms…” BUT planarians are evolutionarily very distant from C. elegans (flatworms vs. roundworms, diverged more than 500 million years ago), making this particularly surprising. These are totally different animals. We find that ingestion of double-stranded RNA induces sequence-specific silencing that persists for months and survives repeated cycles of whole-body regeneration. Even more strikingly, RNAi can be transferred between animals, echoing James V. McConnell’s controversial “RNA memory” experiments from the 1970s (his lab was targeted by the Unabomber terrorist Ted Kaczynski, who sent McConnell a bomb. This and other controversies ended this line of experiments…) Mechanistically, we find that the response transitions from a transient systemic dsRNA-triggered phase to a stable, cell-autonomous post-transcriptional “memory phase” maintained by antisense small RNAs. Using a new luminescence reporter (transgenesis is currently impossible in planarians), we show that silencing spreads along the targeted gene and identify a weird type of planarian small RNAs with untemplated polyA tails. RNAi inheritance without canonical RdRPs establishes planarians as a powerful system for studying RNA-based regulatory inheritance beyond C. elegans and raises the possibility that RNA-mediated inheritance may be more broadly conserved in animals, potentially even in mammals. Here’s a video of a planarian that is treated by RNAi against β-catenin and develops multiple heads instead of just one. This is one of the phenotypes that is inherited. Another phenotype is “loss of eyes” (which we show is not only inherited across multiple regeneration cycles, but can also be transmitted between animals in transplantation experiments). Amazing work led by first authors Prakash Cherian and Idit Aviram (co-supervised by Omri and me). Please read the preprint, the link is in the next tweet, and share!

@J_A_C_S Super awesome!

A Near-Infrared Aptamer:Dye System For Live-Cell Super-Resolution RNA Imaging | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

ScienTek is opening beta access to Aptamize — our in-silico de novo aptamer discovery platform. Access is limited. Selection is intentional. We’re partnering with a small number of ambitious teams working on protein or small-molecule targets where precision and speed matter. If your target is complex, high-value, or traditionally difficult — we want to review it. Apply: info@scientek.io aptamize.com We’ve already begun developing aptamers designed to cross the blood–brain barrier, targeting migraine-associated GPCRs using Aptamize. #Aptamize #Aptamers hashtag#DrugDiscovery #InSilico #Migraine #GPCR #Biotech

Super excited that YC will be hosting a Bio + AI hackathon in March, organized by two awesome companies @BioRender and @tamarindbio. Come to the YC office in SF and hack on the next AI scientist, drug discovery method, or bio data infrastructure. One of the prizes is a guaranteed YC interview 👀 link below!

Programming Aptamer–Protein Complexation Kinetics via Modulation of G-Quadruplex Secondary Structure | Journal of the American Chemical Society @LurieCancer @NorthwesternEng @NUChemistry @ShanaOKelley @NorthwesternU @KelleyLabs pubs.acs.org/doi/10.1021/ja…

On the cover of this week's issue: "Aptamer-Guided, Hydrolysis-Resistant Deoxyoxanosine Enables Epitope- and Moiety-Selective Conjugation to Nonengineered Proteins Even in Complex Environments" Read it here 🔗 go.acs.org/cpw

@XH_Lee23 Looking for a salsa partner…. might a humanoid robot

You can’t imagine how fast Chinese humanoid robots are evolving. In just one year, they have evolved from robots to "humans". 2025&2026 Chinese Spring Festival Gala