Alles Lab

We made the cover (again)!! Thank you so much for supporting our work @TheJournal_Pain @US_ASP 🙏jpain.org/issue/S1526-59…

🎙️ New #Podcast: @Neuroverse_Pod speaks with Professor Sascha Alles, @AllesLab about the complex world of chronic pain. Learn how pain signals are generated & processed, what drives #chronicpain, & how new technologies are transforming our understanding. 🔗buff.ly/5gYoptR

Excited to get things going here @CincyChildrens!!

The Chamessian Lab @WashUPain is recruiting a #postdoctoral research associate to build on the foundational findings from our recent preprint showing that ion channels can be degraded by PROTACs. #TPD #PROTAC #drugdiscovery #pain #ionchannels. We're a fun group with an ambitious mission and incredibly exciting work to do. Join us! Paper: biorxiv.org/content/10.110…

I am pleased to share @silvernonferous (Dr. Adewale Fadaka) newest report on a novel neuroimmune mechanism of inflammatory muscle pain in neonates. The intersection of endocrine signaling and neuroimmune communication ... sciencedirect.com/science/articl…

Great way to kick off 2025 with a visit to see my buddy & fellow human tissue enthusiast @mikehildebrand7 at @cu_research in my hometown 🇨🇦 #painresearch

It is with great pride that I share the bulk of thesis work from my first PhD Candidate @goinsyeah on neuroimmune mechanisms of chronic back pain! This is a new direction for the lab led by Aleyah's sheer curiosity and drive to understand #chronicpain biorxiv.org/content/10.110…

McIlvried, @JohnDR01, @robgereau et al. @WashUPain show that mechanisms of adaptive plasticity are engaged in mouse and human sensory neurons after sustained depolarization. hubs.la/Q02_YmnR0 #CellularPhysiology #MolecularPhysiology

Looks like all members of the @AllesLab will be moving! Most of us to Cincy & one of us for a great postdoc opportunity elsewhere. Excited to see great things from each of you! 💪👩‍🔬🔬 #PainResearch

@HJStratton13 @NIH_NINDS @decouvriez Congrats!!

Very excited to announce that I received my Notice of Award from @NIH_NINDS today for my F32 fellowship!! Thank you to all my mentors and especially @decouvriez for your support and guidance! Looking forward to investigating spinal mechanisms of #chronicpain.

Looks like a great opportunity. If any prospective postdocs are interested in applying for translational medicine project funding to work in my lab in 2026, please reach out! #ChronicPain

Our latest work in collaboration with the @JBIdelaPena lab on the effects of neuropathic pain drug gabapentin on human DRG neurons is now online!! Spoiler alert: interesting donor-specific actions! #PainResearch #humanDRG biorxiv.org/content/10.110…

If we look at thousands of proteins (i.e., signals) in the human blood, the protein most associated with chronic physical and mental illnesses is the **same protein** as the top marker for mitochondrial diseases: GDF15 When mitochondria cannot flux energy properly, the cell makes and secretes GDF15 in the blood to alert other cells Some highlight by Cynthia Liu in our group: - GDF15 is the top predictor for most diseases - GDF15 associated with diabetes is among the most significant protein-prevalent disease associations Based on p-value, GDF15 was most significantly associated with disease. - “GDF15 was associated with the most diseases, containing 205 prevalent and 397 incident diseases, generally acting as a risk factor except for three incident diseases (respiratory diseases affecting the interstitium, disorders of magnesium metabolism, and peripheral artery disease).” - “GDF15, similar to its high ranking with protein-disease pleiotropy, ranked second for protein-trait associations, boasting a substantial 428 associations.”Significant associations with many lipid metabolite markers. - Mental disorders like anxiety disorders, depression, and mood disorders, along with mental health-related traits, also exhibited substantial proteomic signatures including elevated GDF15 - “The fluid intelligence score and various types of dementia shared significant proteins such as NEFL and GDF15 (Figure 2G)” - “GDF15, the protein with pleiotropic effects, was causally associated with several autoimmune diseases, including ulcerative colitis and rheumatoid arthritis (Figure 6B).” Data from >53,000 people in the UK Biobank Full paper here: cell.com/cell/fulltext/… Resource to explore your favorite protein or disease/trait of interest: proteome-phenome-atlas.com

We're honored to once again been named to @usnews Best Children’s Hospitals Honor Roll for the 2024-25 rankings. We ranked No. 1 in three specialties, and we placed in the top 10 for all 10 ranked specialties - cincinnatichildrens.org/news/release/2…

Thrilled to announce that the @AllesLab & family are moving to Cincinnati! We will join the Dept of Anesthesiology @CincyChildrens next year. We look forward to continuing our work on molecular/cellular mechanisms of #chronicpain & starting exciting new projects soon 🎉🥂

The Alles Lab is now on Blue Sky! bsky.app/profile/allesl…

Stellar work!

Recording from hDRG on this chilly snow day! #neuroscience #pain #snow

@nesia505 ice cold!❄️😎

Always exciting to kick off the ASSURE program application season. Know of any college students in #StLouis who are looking for an introduction to research? ASSURE is specifically intended for students who have not had easy access to similar opportunities. #ASSURE2025

Our latest work in @NatureBiotech describing a new molecule with potential for non-opioid pain relief. We developed a prodrug that releases monomethyl fumarate at sites of oxidative stress, relieving pain in models of neuropathy and osteoarthritis nature.com/articles/s4158…