Marcus Basiri

Thrilled to see this paper out in @natBME with @SMitragotri and @Aaron_Anselmo! In it, we describe three approaches for #drugdelivery and their history: modifying the drug, modifying the environment around the drug, and building a delivery system to bridge the two.

Beautiful new preprint from @HeySunKat Skewed X inactivation in genetically diverse mice is associated with recurrent copy number changes at the Xce locus biorxiv.org/content/10.110…

Just out! Angelman syndrome has the potential to be prevented with a CRISPR/Cas9 gene therapy. Early detection, followed by early treatment will be key. Special thanks to our amazing research group and @Angelman @SFARIorg @NINDSdirector. nature.com/articles/s4158…

In non-#COVID19 news, our paper describing Smart-seq3 has been published in @NatureBiotech today! nature.com/articles/s4158… Thanks to everyone who read the @biorxivpreprint. Do check out the final version, we have added quite a few things... ⬇️ #singlecell

Wait, what..?!🤯 Brain control of adaptive immunity! CRH neurons in the hypothalamic PVN & amygdala, which govern responses to fear & stress, are now shown to induce increases in plasma cell numbers & antigen-specific antibodies via splenic nerve. @nature nature.com/articles/s4158…

The gut–brain axis mediates sugar preference nature.com/articles/s4158…

The highest quality Jupyter notebook I've ever seen was just posted by... <checks notes>... ex-CEO of Instagram, Kevin Systrom? All of us data scientists can hang our heads in shame. h/t (@seanjtaylor ) github.com/k-sys/covid-19…

Happy to share our latest work on the multimodal transcriptional analysis on the mammalian habenula. This work was entirely led by twitter-free Yoshiko Hashikawa in the team Stuber lab @gstuber @WhoIsMarkRossi @MarcusBasiri . cell.com/neuron/fulltex…

Not the best of times for the world, but I am excited to announce that our lab website is up at namboodirilab.org. The lab will open at @UCSF on September 1, 2020. We are hiring one postdoc. If you or anyone you know is interested, please contact me by email. Please RT. 1/4

This shows the location data of phones that were on a Florida beach during Spring Break. It then shows where those phones traveled. First thing you should note is the importance of social distancing. The second is how much data your phone gives off.

And then there's 3D ATAC-PALM: super-resolution imaging of the accessible genome from the Tijan and Liu labs to brighten your day. nature.com/articles/s4159… rdcu.be/b21uM

KB: So today we are pleased to introduce the Chromium Single Cell ATAC + Gene Expression solution. 2 modalities in one simple workflow, both at high sensitivity. #AGBT20

Gorin, @vallens and @lpachter extend the RNA velocity, so that when given single cell transcriptomic and proteomic data, rather than predicting what the cell will be like in the future, they infer what it was like in the past. genomebiology.biomedcentral.com/articles/10.11…

RNA imaging and tracking in live cells using a single 57 nt aptamer fusion?!? I’ll admit I thought it would never work, but @Tewoderos14 proved me wrong. Beyond excited to share this work from @HeemstraLab and @BassellLab! biorxiv.org/content/10.110…

@kakoons2 where are you

Every time some asshole here coughs without covering his mouth (which is often, it’s like, not a thing here) I assume he has the corona virus and glare at him like this

Check out our latest preprint on Pnoc expressing neurons in the BNST that encode and promote rapid arousal responses. biorxiv.org/content/10.110… Big shout out to those on twitter: @randall_ung, @MarcusBasiri, @vijay_mkn, @McHenry_Lab, @superkash, @mbruchas and @gstuber.

I find myself having hushed conversations with MD/PhD colleagues about what happens next. My conclusion so far is that the 80/20 research/clinic split that we always talk about isn’t really available. Seems more 100% clinic, 100% research, and many leaving academia. #medtwitter

First, scNT-seq reveals cell-type specific nascent transcription and RNA trajectories in response to brief versus sustained activation. (2/3)

Ultra-high throughput scRNA-seq from Christoph Bock's lab! Combines combinatorial barcoding with droplet microfluidics to sequence >150,000 cells on a single @10xGenomics lane: biorxiv.org/content/10.110…

Thou shalt not make a machine in the likeness of a man's mind.