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📣We just published final results of our CHEERS trial @JAMAOnc investigating the combination of subtotal subablative SBRT ☢️ with anti-PD-(L)1 monotherapy 💉 in pts with advanced solid tumors ja.ma/3pBquxM
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Mathieu Spaas
15 posts
Absolutely, some more insight into overall disease burden is provided in the online supplements 🔎
Nicholas Zaorsky, MD MS@NicholasZaorsky
@MathieuSpaas @JAMAOnc Also, consider disease volume and velocity. If these are high, any therapy may have limited benefit. pubmed.ncbi.nlm.nih.gov/33599706/ If 7/45 pts had progression pre treatment, >2/3 were >1st line systemic tx, 50% had progression at 3 mos follow-up, it is likely a high risk cohort.
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@gv_lazcano @JAMAOnc Similar to PEMBRO-RT and @seanmmcbride we hypothesized that higher SBRT doses might abrogate a potential immune stimulatory effect, based on preclinical data by @CVanpouilleBox
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@MathieuSpaas @JAMAOnc Is there a reasoning for the used SBRT dose when higher doses are used in similar contexts? (Can't access full paper with my institutional proxy)
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📣We just published final results of our CHEERS trial @JAMAOnc investigating the combination of subtotal subablative SBRT ☢️ with anti-PD-(L)1 monotherapy 💉 in pts with advanced solid tumors ja.ma/3pBquxM
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✅Conclusion: while safe, adding subablative multisite SBRT to anti-PD-(L)1 monotherapy did not result in a clinically meaningful benefit
🙏 Thank you to pts, families, trial staff and investigators for participating in this @komop_tgkanker and @VarianMedSys sponsored trial!
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👥 >2/3 polyM+ pts and >1st line systemic Tx
😷 7/45 pts did not complete SBRT due to early PD or intercurrent illness
☢️ SBRT treated lesions were mostly 🫁 mets and lymph nodes
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This phase 2 RCT recruited n=99 with advanced melanoma, RCC, UC, HNSCC and NSCLC across 5 Belgian 🇧🇪 hospitals between 2018-2020
➡️ Randomized 1:1 between 💉anti-PD-(L)1 alone or in combination with ☢️ SBRT 3x8Gy of up to 3 tumor lesions
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Mathieu Spaas रीट्वीट किया
Words of wisdom on the NIVES trial: SBRT + nivo in mRCC. Our take on what is next and abandon the quest for the "abscopal" effect. @MathieuSpaas @NoraSundahl @_ShankarSiva @rweichselbaum
bit.ly/3oOQXDq
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Mathieu Spaas रीट्वीट किया
Really pleased to bring this to fruition. Collaboration between multiple partners to shed insights on combination immunotherapy and radiotherapy, so as to guide best combination therapies! #RTimmuno #checkpoint blockade #precisionRT @ASTRO_org redjournal.org/article/S0360-…
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Mathieu Spaas रीट्वीट किया
Review: Characterisation & classification of #oligometastatic disease: a @ESTRO_RT and @EORTC consensus recommendation thelancet.com/journals/lanon…
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@ReneeBultijnck @piet_ost @AustProstate @hagsie @NoraSundahl @EliseDeBleser @AurelieBruycker Seconded!
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@piet_ost @AustProstate @hagsie Your're the best supervisor a PhD student could wish for! 🤗#phdlife Think others will agree on that @NoraSundahl @MathieuSpaas @EliseDeBleser @AurelieBruycker 😀
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When you think to travel light to @AustProstate #apcc19 but your PhD student @ReneeBultijnck asks you to bring “some” stuff for her research stay with @hagsie...
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Mathieu Spaas रीट्वीट किया
Great news. Let's include as many as possible in the CHEERS trial when starting anti PD(L)-1. Maybe we can further improve the outcome! @JulesBordet #OncoAlert
Philippe Aftimos, MD @aftimosp
#OncoAlert #ImmunoOnc Nivolumab treatment was associated with long-term survival in a subset of heavily pretreated patients with advanced melanoma, RCC, or NSCLC ja.ma/2TeMn10
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