The Science of Parkinson's

Using integrative clinical & genomic analyses, researchers propose a causal role of GPNMB in the bone-brain axis of #Parkinsons, connecting bone mineral density with PD susceptibility nature.com/articles/s4153…

Using Mettl14 conditional knockout mice, researchers identified the ER calcium channel ATP2A3 as a major target of METTL14; METTL14 deficiency significantly⬇️ATP2A3 expression, thereby exacerbating ER homeostasis & ox. stress, leading to neurodegen. nature.com/articles/s4153…

Researchers report a preferential m6A deposition on transcripts of #Parkinsons risk genes & a previously unreported heterozygous METTL3 p.K480R mutation in PD patients; Transgenic mice with m6A hypomethylation in the nigra = neurodegeneration jci.org/articles/view/…

"Blood NAD⬆️slowly, plateauing after approximately 2 weeks of treatment, & declined with similarly slow kinetics following treatment discontinuation"; CNS NAD levels⬆ after 4 weeks of treatment. NAD-related metabolites showed faster⬆️& washout dynamics compared to NAD itself

Researchers report the results of a phase I pharmacokinetic trial assessing systemic & cerebral responses in healthy individuals (n = 6) & people with #Parkinsons (n = 6) receiving 1,200 mg/day nicotinamide riboside or nicotinamide mononucleotide cell.com/iscience/fullt…

New research confirms the positive association between rest tremor amplitude & ipsilateral striatal DAT binding in #Parkinsons patients, but non-PD groups were diagnostically heterogeneous, limiting conclusions about disease specificity neurology.org/doi/10.1212/WN…

Using transgenic mice & #Parkinsons patient IPS cells, researchers report on a single point mutation in Transglutaminase 2 that abolishes only its cross-linking activity, rendering it incapable of causing α-Synuclein aggregation & neurodegeneration pnas.org/doi/10.1073/pn…

Mitochondria in a capsule? Researchers demonstrate mitochondrial transplantation (via erythrocyte membrane encapsulation), rescuing mitochondrial defects in patient-derived cells & #Parkinsons mouse model cell.com/cell/abstract/…

Nice piece of sculptural art at the #adpd2026 meeting - how does it make you feel?

I also liked the @InnoMedica poster presenting their NEON clinical trial results for Talineuren in people with #Parkinsons

Best poster of the #adpd2026 meeting so far - presenting a global alliance for #Parkinsons [clinical trial] platforms (I may be a little biased - @CureParkinsonsT is involved)

Neurodegenerative diseases at the single-cell level, a powerful tool to differentiate and better understand jci.org/articles/view/… @jclinicalinvest

@BrundinPatrik Opps, thanks for the clarification Patrick!

@ScienceofPD I think it was F-DOPA PET. Indeed, the pre- and post graft scans were close to identical with the signals (striatal to occipital ratios) being 0.703 and 0.720 before and 12 mo after grafting, respectively.

Aspen Neuroscience @AspenNeuro present 12-month data from their Phase 1/2a ASPIRO clinical trial (safety, tolerability, & efficacy data of Sasineprocel (ANPD001 - transplanted autologous iPS cell‑derived dopaminergic neuron precursors) in #Parkinsons aspenneuroscience.com/aspen-neurosci…

Arvinas @ArvinasInc presented positive Phase 1 data for their LRRK2 PROTAC, ARV-102 at the #ADPD2026 meeting today; They see >50% LRRK2 degradation in the CSF of people with #Parkinsons treated for 28 days; Safe & well tolerated; Half-life=68 hours ir.arvinas.com/news-releases/…

#NEWS: Arvinas announces Positive Phase 1 data for its #PROTAC LRRK2 Degrader presented at the 2026 International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders (AD/PD™ 2026). Learn more here: bit.ly/4rJcqMH

...and "in all participants with elevated baseline levels of glucosylsphingosine (GluSph) in cerebrospinal fluid (CSF), GluSph decreased substantially after 90 days of treatment with GT-02287" - interestingly GBA1 geneotype had nothing to do with this

Gain Therapeutics @GainThera presented really interesting data at the #ADPD2026 meeting today: Phase 1b trial results for their allosteric glucocerebrosidase (GCase) modulator GT-02287 in 19 people with #Parkinsons; Safe & well tolerated... gaintherapeutics.com/newsroom/press…

The results of the Takeda Pharma Phase 2 trial of TAK-341 (monoclonal antibody for a-synuclein) in Multiple systems atrophy were presented today at the #ADPD2026 meeting - treatment was safe, but no difference between groups (programme terminated)

Encouraging data from Herantis Pharma @HerantisPharma today at the #adpd2026 meeting - Phase 1b data on their small CDNF-like peptide HER-096; Results met all primary & secondary endpoints; Safe & well tolerated; Good biomarker analyse; Phase 2 in 2026 herantis.com/news-events/re…

Encouraging data presented by Roche @roche today at the #adpd2026 meeting - Phase 1b safety, pharmacokinetics, & pharmacodynamics of their NLRP3 inhibitor selnoflast in people with #Parkinsons; Positive data (safe with peripheral & central effects); No mention of next steps