Eric Topol

A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon. amazon.com/gp/new-release…

Largest clinical trial to test hydration and below is the increase in urinary volume throughout the 2-year study

If you've had a kidney stone, you've been advised that the most important thing to prevent another bout is to increase hydration. Now a randomized trial of hydration in over 1600 participants showed no benefit, despite evidence of increase during volume. thelancet.com/journals/lance…

@dumbassgenius that's what I thought, Rick

@EricTopol Well, shit!

New @ScienceMagazine Discovery of a circuit that connects stress and skin inflammation science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

More on this here erictopol.substack.com/p/the-big-shif…

The 4 biomarkers to meaningfully assess a person's risk of coronary artery disease @rayshafarah @aklfahed @pnatarajanmd @JACCJournals @uk_biobank sciencedirect.com/science/articl…

@rayshafarah @aklfahed @pnatarajanmd @JACCJournals @uk_biobank Great paper for the essentials of assessing CAD risk!

@EricTopol @aklfahed @pnatarajanmd @JACCJournals @uk_biobank Thank you so much for highlighting our work! We hope this framework helps move us closer to earlier, targeted prevention for heart disease.

The negative oral Ozempic randomized trials (EVOKE, EVOKE+) for Alzheimer's disease have now been published @TheLancet thelancet.com/journals/lance…

GLP-1 drugs have established benefit for Type 2 diabetes. New data suggests that extends to Type 1 diabetes, with heart, vascular, and kidney protection nature.com/articles/s4159…

So this is what GuardDog Telehealth did with patient medical records

Your insurance.....;-)

@Nature @HugoAerts @simonbernatz @NatureNV Topnotch teaching video and thread by @HugoAerts, senior author of the 2 @Nature papers x.com/HugoAerts/stat…

@Nature @HugoAerts @simonbernatz Think about that @NatureNV nature.com/articles/d4158…

Big implications, folks, for today's new reports on the thymus gland and healthspan —Our thymus gland largely involutes after the teenage years, but AI used to determine its persistent level of health —Healthy adult thymus linked to an array of remarkably improved health outcomes in 2 cohorts —Cardiovascular incidence and mortality reduced (Figure); also less all-cause mortality —Pulmonary mortality, digestive disease, metabolic disease mortality reduced (Figure) —Reduced inflammation; reduced lung cancer; improved metabolic markers nature.com/articles/s4158…

Questioning the benefit of an implant to close the left atrial appendage vs medical therapy in a randomized trial @NEJM nejm.org/doi/full/10.10…

A new finding after stopping GLP-1 drugs in a large cohort with Type 2 diabetes: rapid erosion of CV benefit/protection New @bmj_latest by @zalaly @Biostayan bmjmedicine.bmj.com/content/5/1/e0… See thread: x.com/zalaly/status/…

19% more deaths from Covid in the US than counted thru 2021 science.org/doi/10.1126/sc…

What if we could engineer T cells in the body, making CAR T vs cancer, autoimmune diseases, and other applications far more practical, much less expensive? A step forward today via genome editing T cells nature.com/articles/d4158… nature.com/articles/s4158…