Cédric Chaveroux

#ResultatScientifique🔎| Des scientifiques ont découvert que la protéine eIF5A, activée par hypusination, agit comme un "chef d’orchestre" et contrôle la progression du cancer de la prostate ✍️ @frederic_bost 📕 @NatureComms ▶️ nature.com/articles/s4146… 👉 insb.cnrs.fr/fr/cnrsinfo/lh…

Building on our Cell Met 2019 study, we show why some DLBCL patients relapse after L-asparaginase: metabolic rewiring drives DNA damage and PARP1/2 dependence. Targeting this with olaparib exploits resistance and enhances killing. Kudos to @ChicheJohanna nature.com/articles/s4146…

A novel potent and selective GCN2 inhibitor, APL-4098, has anti-leukemic activity through dysregulation of mitochondrial function aacrjournals.org/clincancerres/…

Our latest work describing how viral infections drive functional remodeling of ribosome-associated factors is out as a preprint! biorxiv.org/content/10.648…

Glad to share our latest review written with Dr @AltintasDogus , Marina Cerqua and Pr Paolo Comoglio on the "The Janus framework of the integrated stress response: from homeostasis to maladaptation" life-science-alliance.org/content/9/3/e2…

Role of the Gcn2 pathway in CAR-T cells nature.com/articles/s4142…

Why is the UPR activated upon glucose deprivation? a reviewer asked. Why is IRE1 activated when glucose is low? a committee member for Mabel Cruz's PhD asked. Mabel was surprised about the questions (is this not widely known?) So we wrote a review about it with Eric Chevet.

Today we were pleased to welcome @AltintasDogus, who presented his latest work on the role of ISR-mediated translational reprogramming. Thank you Dogus for a very informative presentation and discussion. Interested, see dx.doi.org/10.1038/s44318…

Our collaborative work with Vincent Vanoosthuyse's group, describing the use of virus-like particles to deliver ready-made RNaseH into cells and study RNA/DNA hybrids is out! biorxiv.org/content/10.110…

Congratulations to @auner_lab_CH 👏👏👏for this new paper on GCN2-dependent but ISR-independent translation control mechanisms. And so many insights behind these remarkable results.... life-science-alliance.org/content/8/5/e2…

Here I discuss the link between metabolism and immunosurveillance and how to exploit this link to improve treatment. I hope you find it interesting and useful. 🤗 Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets: Cell Reports cell.com/cell-reports/f…

Mbf1 is required for optimal GCN2 activation. Great work from Drs R. Green and HS Zaher. sciencedirect.com/science/articl…

Thanks to @FredericPerros for highlighting the need for human-relevant preclinical models in PVOD translational research—a challenge in many chronic diseases.. Bridging the species divide: The limits of rat models in capturing human PVOD mechanisms. onlinelibrary.wiley.com/doi/10.1002/pu…

Great study from Maragkakis lab. sciencedirect.com/science/articl…

Our work demonstrating that GCN2 plays a dual role in controlling ribosome biogenesis in both proliferative and stressed contexts, is out. Original data but also novel questions to address regarding this fundamental pathway....Thanks to all participants.

The role of GCN2 in controlling ribosome biogenesis in colon cancer #CancerResearch #RibosomeBiogenesis #FEBS #MolOnc Read More: febs.onlinelibrary.wiley.com/doi/10.1002/18…

#PodcastCNRS 🎧 Et si, à la place d'une injection 💉, les futurs #vaccins pouvaient fondre sous la langue ? Explication avec Claire Monge, biologiste CNRS, dans ce nouvel épisode de "Qu’est-ce que tu cherches ?" 👉 smartlink.ausha.co/cnrs-qu-est-ce…

Point of View: Applied research won’t flourish without basic science | eLife elifesciences.org/articles/102368