Dogus Altintas

Today @Fondaz_Veronesi awarded me a research grant to pursue my work on how cancer cells rewire protein synthesis to promote survival, progression, and therapy resistance. This support will allow me to explore how non-coding alterations shape disease evolution.

Meet Romulus and Remus—the first animals ever resurrected from extinction. The dire wolf, lost to history over 10,000 years ago, has returned. Reborn on October 1, 2024, these remarkable pups were brought back to life using ancient DNA extracted from fossilized remains. Watch the pups grow up and catch exclusive videos on our YouTube channel. @itiscolossal" target="_blank" rel="nofollow noopener">youtube.com/@itiscolossal

In issue 4: FAM134B isoforms control ER dynamics in myogenesis Bacterial virulence factor targets both neutrophils & complement system Special pericytes in pulmonary capillaries Cover: 1st plant spliceosome structure by Yichen Lu, Ke Liang & Xiechao Zhan embopress.org/toc/14602075/4…

Translation re-initiation at uORFs by noncanonical translation factors MCTS1-DENR does not require their homolog eIF2D, but can be aided by MCTS2 as new DENR partner David Gatfield and collaborators embopress.org/doi/full/10.10…

The integrated stress response drives MET oncogene overexpression in cancers Dogus Altintas @AltintasDogus, Paolo Comoglio et al embopress.org/doi/full/10.10…

Our new study in The EMBO Journal reveals how the Integrated Stress Response (ISR) drives MET oncogene overexpression in cancers. This breakthrough uncovers a key link between stress adaptation and cancer progression. 🧬 Read more: doi.org/10.1038/s44318…

Today @fondazioneumbertoveronesi awarded me a research grant to pursue my work on the interplay between integrated stress response and invasive growth. I am thrilled to be with my daughter and my beloved wife for this important moment organised by Fondazione Veronesi.

Thanks to the @Fondaz_Veronesi for supporting our research. We will keep doing our best to uncover mechanisms behind resistance to targeted therapies. @Comogliogroup

One of my favorite @nature covers for this week’s issue

Such a pleasure to start the day with such an e-mail. Better ones are coming soon...

Very happy to publish the molecular mechanism of the rebound effect to MET-targeted therapy in cancer! @IFOMresearch @AIRC_it @Fondaz_Veronesi @Comogliogroup

The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor mdpi.com/1890008 #mdpiijms via @IJMS_MDPI

A new MET functional domain @ResearchGate: researchgate.net/publication/36…

Did you think that MET oncogene was only a tyrosine kinase? Check out our new research paper revealing an unsuspected enzymatic activity of the receptor. Online soon at the special issue of IJMS... @IFOMresearch @AIRC_it @fpoirccs

@GDarmanin Un visage rasé et un costume auraient été plus appropriés. Le ministère n’est pas un start-up!

Vous êtes nombreux à m’avoir demandé ce que contient concrètement la loi de programmation et de modernisation du ministère de l’intérieur (LOPMI) que j’ai présentée cette semaine. Mes explications 1/2👇🏼

@DaddyMI5 @brault_helene The tweet is in English and perfectly describes the position. The French part describes how to apply, ie cover letter and CV, like all academic positions worldwide.

@brault_helene Hello Prof. The advert would have been better placed in English for international understanding. Thanks

URGENT : I am looking for a PhD candidate to work on the synthesis of nanoMOFs for luminescence thermometry. That is in collaboration with ICGM of Montpellier. Please RT🙏. #MOFs #thermometry #Chemistry

Mutated MET∆14 kinase is not constitutively active but requires HGF. The response to the ligand is stronger and long-lasting, protecting cancer cells from apoptosis and driving invasive growth. @IFOMresearch @AltintasDogus @Comogliogroup @airc_it bit.ly/3NPnBQQ

MET∆14 promotes a ligand-dependent, AKT-driven invasive growth. By Altintas & Comoglio et al. @IFOMresearch @AltintasDogus @Comogliogroup life-science-alliance.org/content/5/10/e…

MET∆14 promotes a ligand-dependent, AKT-driven invasive growth. doi.org/10.26508/lsa.2… @LSAjournal @IFOMresearch @Comogliogroup