Haopeng Wang

Thrilled to share our latest #Cell paper revealing how the immune checkpoint LAG3 switches "OFF→ON"! Huge thanks to our incredible team @ShanghaiTechUni , @ChenqiXuSH , @Vignali_Lab , @BeOneMedicines #Cancer #Immunology #CancerTreatment cell.com/cell/fulltext/…

In the latest issue! Cell death in cancer dlvr.it/TS6BPY

『Coordinated IL-2 and TGF-β Signaling via a Novel Fusion Protein Selectively Expands and Activates Regulatory T Cells』 bioRxiv　March 11, 2026. CUE-401はIL-2とTGF-β3を組み合わせた二機能性バイオ医薬で、Tregを選択的誘導・増殖・安定化させ自己免疫反応を抑え動物モデルで免疫寛容達成

Our preview on the FIRST AAV-based in vivo CAR-T： No leukapheresis. No ex vivo manufacturing. Just inject. AI-engineered AAV selectively targets CD62L⁺ naive T cells → reverses SLE in humanized models 📖 vita-journal.com/vita/EN/10.153… #InVivoCART #AAV #GeneTherapy #SLE

Now online! Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation dlvr.it/TRC81z

❌ CAR-T exhausted before seeing the tumor — a Tonic Signaling Issue ✅ Charge optimization → Tscm preserved, durable tumor control in HNSCC. The lesson: CAR biophysics = T cell fate Proud of Dr. Chen, now independent PI @FudanUniversity advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

𝗥𝗲𝘁𝗵𝗶𝗻𝗸𝗶𝗻𝗴 𝗖𝗔𝗥-𝗧 𝗳𝗼𝗿 𝗔𝘂𝘁𝗼𝗶𝗺𝗺𝘂𝗻𝗲 𝗗𝗶𝘀𝗲𝗮𝘀𝗲: Our new study challenges the "transient depletion" paradigm: Genetic lupus needs persistent, not transient, CAR-T therapy. @JMCellBiol academic.oup.com/jmcb/advance-a…

Congratulations to Honggui, Jiankun, and Tan for improving the single-cell 3D genome resolution by a factor of 4 (to 5 Kb). This allowed direct visualization that multiple enhancers cluster to a particular gene promoter at the same time in a single cell. nature.com/articles/s4158…

@XieSunney Big Congrats, Sunny! What a Incredible work! 🧬

What a beautiful study from Dr. Bernard Malissen! A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo rupress.org/jem/article/22…

In the latest issue! Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs dlvr.it/TKZSzG

Congrats to Xinyao and Xie Chen! In eukaryotes, multiple transcription factors bind cooperatively to a regulatory region on genomic DNA to control gene expression. In this paper (bit.ly/3GV1BoP), we present an experimental metric for quantifying such cooperativity.

Understanding LAG3 immune checkpoint function nature.com/articles/d4157…

Just out in @CellCellPress! Prof. Kai W. Wucherpfennig previews our study: “Unlocking LAG3: Ubiquitin’s Unexpected Role.” LAG3's non-degradative poly-Ub by Cbl ligases flips this checkpoint ON and marks TILs that respond to PD-1/LAG3 combo therapy. cell.com/cell/fulltext/…

Science Spotlight: New insight into LAG3's checkpoint function, a blood-based T cell assay for Type I diabetes, a degrader using a new E3 ligase, and paper from newcos. BioCentury's roundup of translational innovations buff.ly/RYy1W0J

Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function. @HaopengWang_Lab found ubiquitination of LAG3 promotes its inhibitory function rather than its degradation, and is required for suppression of antitumor immunity in vivo. ow.ly/xOKh50VkhNt

Just published a review on CAR-T tonic signaling and introduced the "Peak Theory"—finding the optimal signaling level to overcome T-cell exhaustion and enhance efficacy in cancer, autoimmune diseases, and more. link.springer.com/article/10.100… #Immunotherapy #CART

D-STAR: The Gemini Guardians redefining dual-targeting of immune cell ... sciencedirect.com/science/articl…

Now online! Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs dlvr.it/TJZsP5

Thrilled to share our @SciImmunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to @MasubuchiTakeya for leading this work, and @jackbuimdphd @ZhengtingZou @CWu2009 et al. for collaboration.science.org/doi/10.1126/sc… See also excellent media report by @mario_maguilera today.ucsd.edu/story/scientis…