Takeya Masubuchi

@sciqst @hui_enfu @jackbuimdphd @ZhengtingZou @CWu2009 Great question! A fully humanized PD-1 mouse model or other animal models closer to humans might be the way forward. Still plenty of work ahead!

Congratulations on the publication! Analyzing PD-1's functional divergence across species is crucial for refining immunotherapy strategies. What implications do you foresee for treatment protocols in humans based on these findings? Given the translational gap between mouse models and human responses, how might this research inform future experimental designs or therapies? For anyone interested in a deep dive into biomedical insights, check out sciqst.com. It's an excellent resource for generating comprehensive reviews in the biomedical field. #Medicine #Immunotherapy

Excited to share our latest paper describing the functional divergence of PD-1 across species. Thank you for @hui_enfu for the invaluable guidance, and @jackbuimdphd @ZhengtingZou @CWu2009 et al. for wonderful collaboration! science.org/doi/epdf/10.11… today.ucsd.edu/story/scientis….

I'm deeply grateful for the support provided by the @HFSP long-term fellowship and the @JST_Kisokenkyu PRESTO (Sakigake) Grant for this work!

@YunlongZhao15 @hui_enfu @jackbuimdphd @ZhengtingZou @CWu2009 Thanks Yunlong! This is a great start of 2025. Wish you a wonderful year, too!

@MasubuchiTakeya @hui_enfu @jackbuimdphd @ZhengtingZou @CWu2009 Congrats on your amazing work 🎊 The best present for the new year! Wish you another fruitful year!

Thrilled to share our @SciImmunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to @MasubuchiTakeya for leading this work, and @jackbuimdphd @ZhengtingZou @CWu2009 et al. for collaboration.science.org/doi/10.1126/sc… See also excellent media report by @mario_maguilera today.ucsd.edu/story/scientis…

Today we report on @eLife mechanisms by which similar immune checkpoint receptors show different preferences on SHP1/2, and that PD1 has an atypical ITIM. Congrats to @XiaozhengX @MasubuchiTakeya Thanks @ReviewCommons for reviewing & referring our preprint doi.org/10.7554/eLife.…

Great to see our eLife paper entitled "Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors" published online!!! doi.org/10.7554/eLife.… @eLife @hui_enfu @YunlongZhao15 @MasubuchiTakeya @XiaozhengX

Excited to share our new paper @CellCellPress! Really happy to be co-author of this amazing work. Congratulations to all!

Review article of Single molecule protein sequencing. Reminds me discussion with Dr. M. nature.com/articles/s4156…