Hofmann_Lab

64 posts

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Hofmann_Lab

Hofmann_Lab

@LabHofmann

Research group at the University of Cologne

Bergabung Temmuz 2020
113 Mengikuti163 Pengikut
Hofmann_Lab
Hofmann_Lab@LabHofmann·
I am deeply saddened learning that my scientific hero Amos Bairoch has recently passed away. He will be remembered as the mastermind behind the SwissProt and many other endeavours in protein bioinformatics. There is a tribute web page at sib.swiss/amos/
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DaSpin
DaSpin@DrRanabirDasLab·
Big day for the lab-our PI Dr. Ranabir Das @RanabirNMR has been promoted to Professor! Congratulations 🎊🎊on the achievement. Your leadership, vision and science continue to inspire us every day. Onwards and upwards🚀
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Hofmann_Lab
Hofmann_Lab@LabHofmann·
For all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. biorxiv.org/content/10.648…
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Niko Klink
Niko Klink@NikolasKlink·
Excited to share that our work on Parkinson's target USP30 has been published in Nature Structural & Molecular Biology! By combining DUB-domains onto USP30, we for the first time achieved crystallization with a small molecule (NK036) without Nanobodies! nature.com/articles/s4159…
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Hofmann_Lab
Hofmann_Lab@LabHofmann·
Congratulations, great paper! But what makes you think that this is a CARD and not just any death-fold domain? pyrin and DEDs can also activate caspases and invertebrates use all kinds of death-fold domains for that purpose! I don't think this one really should be called CARD.
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We previously showed that bacteria encode the pore-forming protein gasdermin and that it defends against phage infection science.org/doi/10.1126/sc… BUT the mechanism by which the gasdermin system defends bacteria against phage remained unknown.

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Hofmann_Lab
Hofmann_Lab@LabHofmann·
Great paper, but sorry, this is *not* a CARD domain! It is a 6-helix death fold domain for sure, but there in no evidence provided that it belongs to the CARD subfamily. It might have (convergently?) acquired a similar function as mammalian caspase-associated CARDs. Just saying.
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Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems Congrats @TanaWein! Thanks Kranzusch lab! tinyurl.com/CA88DD

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Pedromics
Pedromics@pedromics·
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Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158…
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For all ubiquitin, deubiquitinase and chemical biology aficionados: Here's a preprint from the lab introducing 2 new active DUBs in humans & a unique type of DUB activity one would miss with the widely used panels of free ubiquitin chains. t.ly/GnRVv Thread👇(1/10)

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Ole Schmöker
Ole Schmöker@oleschmoeker·
New Lammers Lab paper out now in @NatureComms!🥳 We reveal high functional diversity within bacterial deac(et)ylases by systematic functional/structural characterization. This is Leonies PhD project and I’m grateful to have contributed to this great work. nature.com/articles/s4146…
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Jane Dudley
Jane Dudley@Jane_Dudley_Lab·
Endlessly fascinating and exciting conference with great discussions #EMBOubiquitin24 ! Can’t wait to get back to the lab with some new ideas…
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Margot Raffeiner
Margot Raffeiner@MargotRaffeiner·
This was such a great meeting! 🤩 Thanks a lot again to the organizers for this nice and so well-organized event (and obviously again for the opportunity to talk about my research 🌱)! I have learned so much in the last three days!!! #PP2024
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Jelajahi

@FelthamLab @WEHI_research @TrujilloLab @DrRanabirDasLab @RanabirNMR @Rashmi_Agrata @MalteGersch @maxplanckpress