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📢 A novel gene therapy for #Dravet. jci.org/articles/view/…. Using Canine adenovirus-2 (CAV-2) we delivered the full SCN1A coding sequence into the hippocampus and thalamus of juvenile Dravet mice.
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RubinsteinLab
370 posts
RubinsteinLab
@LabRubinstein
We are located in @TelAvivUni. We study the neuronal and molecular basis for severe epilepsy and autism.
Israel Bergabung Ekim 2018
477 Mengikuti388 Pengikut
Congratulation!! 🥳🥳🎈🎈
HaitinLab@HaitinLab
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
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RubinsteinLab me-retweet
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
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RubinsteinLab me-retweet
Excited to share our new paper in @FEBSJournal! 🎉
We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation
🔗 doi.org/10.1111/febs.7…
@peterslab1 @TAUMedFaculty
HaitinLab@HaitinLab
🚨New preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation bit.ly/3ZR7w47 #MultipleMyeloma
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Congratulations!! 🥳🥳
HaitinLab@HaitinLab
How does a cytoplasmic enzyme make a membrane product? 🤔🧬 We found that a hydrophobic residue cluster helps the human cis-prenyltransferase feed its product into the ER membrane! MD simulations + fluorescence = mechanistic insight 👇 🔗doi.org/10.1002/pro.70…
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RubinsteinLab me-retweet
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵biorxiv.org/content/early/…
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@HaitinLab @peterslab1 @AlbGiacomello @TAUMedFaculty @of_sagol Congratulations !!🍾💃🪩 an exciting global collaboration 🌍
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💃🕺Happy to share a team effort to uncover the molecular "dance" behind human cis-prenyltransferase regulation!🔬🧬 @peterslab1 @AlbGiacomello #Biochemistry #StructuralBiology @TAUMedFaculty @of_sagol biorxiv.org/content/10.110… biorxiv.org/content/10.110…
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An outstanding group of devoted students - Mor Yam, Jolan Nassir, Danielle Galber, Shir Quinn, Roni Gal, Eden Peled, Mor Ovadia, Mor Bordeynik Cohen; Wayne Frankel, Christopher Makinson, Moran Hausman-Kedem, Aviva Fattal-Valevski. @TAUMedFaculty
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Excited to share our paper! #GRIN2D-DEE 🐭model mirrors patient symptoms, from behavioral deficits and pathological brain activity to synaptic changes🔗 shorturl.at/JL6pyA
An incredible collaboration with a GRIN2D family, @KarenAvraham, researchers & clinicians.
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Thrilled to announce that I've been selected as a 2025 Leon Levy Scholar in Neuroscience! Grateful for this opportunity to advance my research and join a community dedicated to groundbreaking neuroscience in NYC. @NYASciences
NYAS@NYASciences
Congratulations to the 2025 #LeonLevyScholars!🎉 Announcing the 2025 #LeonLevyScholars, in partnership with the Leon Levy Foundation. Recipients participate in a multi-year postdoctoral program to advance their careers. Read more about the Scholars: bit.nyas.org/3Yoa6Pf
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Excited to share our upgraded #CHD2 mouse model! 🐭🧠 It better mimics the disorder, revealing key symptoms like motor deficits, autistic features & altered brain function⚡️
An amazing collaboration with @IgorUlitsky, supported by @curechd2.
🔗 Read more: biorxiv.org/content/10.110…
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RubinsteinLab me-retweet
💖Love, Science & the Brain💖
This #ValentinesDay, meet Profs. Moran Rubinstein & Yoni Haitin - a couple bonded by love & a passion for #neuroscience. From BSc to leading labs, their journey is proof that great discoveries are made together.
🔬 Read more:
linkedin.com/feed/update/ur…
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🚨New preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation bit.ly/3ZR7w47 #MultipleMyeloma
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1/ How do animals integrate different forms of learning? Our @Eyal_Roz new study in @ScienceAdvances shows that active mechanisms prevent the co-formation of competing memories. Here’s what we found! 🧵👇
science.org/doi/10.1126/sc…
Art by @Ella_Maru
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It’s hard to imagine new discoveries about the NMDA receptor, one of the most studied molecules in #Neuroscience. But the brilliant minds in my lab—Antonella Ruggiero @AlLeN_OtNa_85, @LeoreHeim, and @LeeSusman—are here to surprise you! 👇
@of_sagol @TAUMedFaculty
Antonella Ruggiero@AlLeN_OtNa_85
1/I’m honored to finally share our new paper in @NeuroCellPress ! Some good news during this challenging time here in Israel. We uncovered a new role for NMDA receptors in regulating spontaneous hippocampal network activity! 🤩doi.org/10.1016/j.neur…
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🚨📣Excited to share we found Magnesium’s 🏠| By combining computational and experimental approaches we identified the magnesium binding site in NCX, exposing the structural basis for its physiological modulatory mechanism. Led by @Bargamish @TAUMedFaculty onlinelibrary.wiley.com/doi/10.1002/pr…
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