The FEBS Journal

🎉 We are thrilled to share our newest collection: Biochemistry & beyond 🎉 Through our commitment to publishing rigorous, high-impact research in all aspects of the molecular life sciences, the journal brings together diverse communities. 🔎To get you started on your Biochemistry & Beyond journey with us, explore our inaugural collections on: 🪴Plants & biotechnology, 🐁Organismal biology, 🫀Cardiobiology, 🔬 Developmental biology & Stem cells, 🧬RNA biology & epigenetics. Explore our newest collections, here ➡️ buff.ly/MFwRpDl 🚀 At The FEBS Journal, biochemistry is the starting point – not the limit! #BeyondBiochem

Structural insights into θ‐type carbonic anhydrases 3 and 4: Tuning the directionality of CO2 hydration in a diatom febs.onlinelibrary.wiley.com/doi/10.1111/fe… @FEBSJournal

⏰ Our Issue 14 is online! 🧬 From targeted protein degradation to enzyme mechanisms and cancer biology, dive into our latest collection of molecular life sciences research: 👏 The Editorial celebrating our 2026 Richard Perham Prize winner, Angela M. Gronenborn. 🧩 A Structural Snapshot article delving into how enzymes work by introducing an ensemble–function framework that quantitatively dissects enzyme catalysis to redefine how we understand biomolecular function. 🖇️ A State-of-the-Art review on how TRIMTACs use the unique E3 ligase TRIM21 to selectively target protein aggregates and expand the reach of targeted protein degradation. 🌟 Research Highlights collection spotlighting four standout studies from this issue. 🔬 An Editor's Choice article that reveals endogenous LINE-1 ORF2p in breast cancer cells and points to its potent reverse transcriptase activity. 🚀 And a vibrant selection of original research from across the life sciences. Discover our latest issue, here ➡️ buff.ly/Chz8Zxa #E3ligase #enzyme #reversetranscriptase #tasmaniandevil #AuroraB

🔎 Explore the outstanding research featured in our new 'Plants & Biotechnology' collection! 🌍 Unveiling the mechanisms of plant physiology and pathology has critical implications for Earth’s ecosystems and all forms of life. 🪴The articles in this collection cover a broad range of basic and applied studies in plant biology, genetics, ecology and biotechnology. Discover our first article in this collection, here ➡️ buff.ly/nZTiFzR 🚀 At The FEBS Journal, biochemistry is the starting point – not the limit! #BeyondBiochem

✨ Today, we invite you to read our ‘A Guide To…’ article, featured in our latest Special Issue on ‘Extracellular Matrix- Proteases Crosstalk’. ✂️ The roles of matrix metalloproteinases (MMPs) in cancer are highly complex and context-dependent, making them challenging targets. This article brilliantly delivers a comprehensive breakdown of the types, structures, and functions of MMPs, summarizing their essential roles in normal and pathophysiological conditions, with a special focus on cancer progression. 📕 A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer 📖 Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non-proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial-to-mesenchymal transition. Alongside extracellular vesicles, MMPs support pre-metastatic niche formation, enabling cancer cell dissemination, dormancy, and metastatic colonization. ✍ Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos Karamanos Read the complete guide in our Special Issue, here ➡️ buff.ly/CAUZhe3 #MMP #cancer #guide #ECM

✨ We are thrilled to award the Richard Perham Prize to NMR pioneer and long-standing Editorial Board member, Professor Angela M Gronenborn. Recognizing her exceptional contributions to The FEBS Journal, the award was presented by our Editor-in-Chief, Professor Seamus Martin, at the FEBS Congress in Maastricht. 🎉 Please join us in congratulating Angela and in thanking her for her tireless service to The FEBS Journal.

🚨 New Issue Alert!🚨 🌟 We’re excited to announce the publication of our new Special Issue, ‘Extracellular Matrix—Proteases Crosstalk’, guest edited by Prof. Nikos Karamanos (University of Patras), a renowned expert in the field. ✂️ This issue features fifteen excellent review articles covering a broad range of topics at the intersection of proteases and extracellular matrix (ECM). 👉 In this issue, you can delve into: - Matrix metalloproteinases (MMPs) as key ECM regulators and their dysregulation in pathological contexts. - Proteolysis-mediated molecular turnover within the ECM, offering new insights into irreversible ECM proteolysis. - Proteases as catalysts of pro-LOX and pro-LOXL hydrolysis, - The role of ADAMTS and their association with extracellular vesicles, - The future of ECM degradomics for diagnostics and therapeutics. 🩺 The reviews in this Special Issue reflect the complex phenotypes associated with ECM-related pathologies. Explore this excellent selection of review articles here ➡️ febs.onlinelibrary.wiley.com/toc/17424658/2… #ECM #protease #MMP #ADAMTS #proteolysis #degradomics #cancer

⌛ 48 hours and counting! The wait is almost over for the milestone 50th FEBS Congress in Maastricht. This incredible five-day event will bring together over 2,000 enthusiastic researchers to discuss groundbreaking science, network, and collaborate. ☑️ The FEBS Journal's editors regularly attend this yearly event, and we have last-minute tips and tricks that will help you savour everything this exciting event has to offer. Visit our FEBS Network post to find out the '6 tips to make the 50th FEBS Congress your favourite conference' ➡️ buff.ly/8Tq4hL9 #FEBSCongress2026

🌟 We're very excited to meet researchers from around the world at the 50th FEBS Congress, in Maastricht next week. 📅 Please mark your calendars for the fourth day of the congress (July 7, 2026) for The FEBS Journal Perham Prize Lecture. The Richard Perham prize was established in 2016 to honor exceptional contributions to The FEBS Journal. We are extremely proud to announce that the recipient of this year's Richard Perham prize is NMR pioneer and long-standing Editorial Board member, Professor Angela M Gronenborn. 💬 Prof. Gronenborn will be giving her talk entitled 'The awesome power of fluorine NMR - from drugs to cells' and we can't wait to hear her speak. 👉 In the meantime, get inspired by the recently published Editorial introducing Prof. Gronenborn's excellent research career and get to know her better ➡️ lnkd.in/dbM2ZFiV #RichardPerhamprize #NMR #biomolecularstructure #50thFEBSCongress

Our latest paper explores the Sorting Nexin protein Snx21 to show that it interacts with flotilins to promote endocytosis in Drosophila. @FEBSJournal Congratulations to Tomi, Enikő and the whole team! febs.onlinelibrary.wiley.com/doi/10.1111/fe…

🧬 Street and colleagues highlight RNA-binding proteins (RBP) and discuss recent technological advances that expand our capacity to map and interpret post-transcriptional regulatory networks in their State-of-the-Art Review published in our latest issue. 🔎 Additionally, they outline key future analytical and experimental innovations that could transform our understanding of RBP function, enabling a comprehensive understanding of the complexities of gene expression control and its disruption in disease. 📕 Post-transcriptional regulatory networks: The dynamic interplay of RNA-binding proteins 📖 Post-transcriptional gene expression regulation is controlled by RNA-binding proteins (RBPs), which influence many processes including splicing, localization, translation, and decay. Rather than acting alone, RBPs bind RNAs combinatorially, forming complex, context-dependent regulatory networks. Recent advances, including multiplexed RBP–RNA-binding assays, interaction proteomics, RNA pulldowns, imaging, and high-throughput screens, are enabling systems-level mapping of these networks, advancing understanding of coordinated RNA regulation and its disruption in disease. ✍ Lena Street, Marko Jovanovic, Eugenio Fornasiero Discover this excellent State-of-the-Art Review, here ➡️ buff.ly/xDWaTmw #RNAbindingproteins #RNA #Posttranscriptionalregulatorynetworks #geneexpression #innovation

🗓️Mark your calendars! The EACR Conference on Cancer Metabolism will once again gather top experts in the field in Bilbao this October! 🔋This symposium will highlight key topics including undocumented metabolic alterations in cancer, cancer-host metabolic communication, and metabolite-based regulation of cellular responses. ⏰ Don't miss the travel grant application and abstract submission deadline next week, 29th June. The deadline for registration and payment is 7th September. For further details, please visit 👉 buff.ly/71hHRwY #EACR #cancermetabolism #metabolicalterations #metaboliccommunication #metabolites

📌 Our Issue 12 is now online! In this issue, you'll discover outstanding studies spanning a diverse range of life sciences topics: 🧬 A State-of-the-Art Review exploring the regulatory role of RNA-binding proteins in post-transcriptional gene expression, offering fresh perspectives on recent advances in this rapidly evolving field. 🧩 A Structural Snapshot that discusses recent structural knowledge on the interaction of low-density lipoprotein (LDL) and its receptor, as well as the structural heterogeneity observed in apoB-100. 👂 An Editor's Choice article on hidden hearing loss (HHL), investigating GLAST-deficient mice that exhibit characteristic features of HHL and emphasizing the critical role of GLAST, particularly in age-related hearing loss. The article is accompanied by an insightful Commentary ✍ by Paul K., Lukas Landegger. 🌟 Several additional original research articles covering a broad spectrum of topics across the life sciences. 🔎 We invite you to explore this exciting collection of research and discoveries! ➡️ buff.ly/nX03226 #RNAbindingprotein #lowdensitylipoprotein #hearingloss #amyotrophiclateralsclerosis

🩸 Despite decades of advances in prevention and treatment strategies, malaria continues to be one of the world's most significant health challenges. 💉 Recent research highlights the importance of Falcipain-2, an enzyme that enables the malaria parasite to digest human hemoglobin. In their study published in our journal, Nath et al. uncover the molecular basis of Falcipain-2 binding to hemoglobin and provide insights into its regulation. 🌟 For further reading, dive into our FEBS Network post, here ➡️ buff.ly/EOR9yBa 📕 Read the full study here, where the authors uncover an unprecedented mechanistic basis that could guide the development of PEG derivatives with potent antimalarial efficacy ➡️ buff.ly/171bEj5 #malaria #Falcipain #PEG400 #FP2 #hemoglobin

🚀 Our Issue 11 is now online! In this issue, you'll find: 🌟 A mini-review focusing on Nedd4 ligases, offering an in-depth look at its regulation and wide-ranging effects on diverse cellular pathways. 🌟 A Viewpoint article bringing a thorough, fresh perspective on metabolic thermodynamics. 🌟 Our new Hidden Gems collection highlighting standout original research articles published in our journal in 2024. 🌟 An Editor's Choice article featuring a newly uncovered role for the oxygen-independent expression of HIF-1α in hepatocellular carcinoma, accompanied by an expert commentary. 🌟 And several original research articles advancing our understanding of key mechanisms in the life sciences. Explore our newest issue, here ➡️ buff.ly/X6Smt3W #nedd4 #metabolicthermodynamics #hiddengems #hif1 #yeast

💡 Bioluminescence is more than just a pretty glow! By adapting bioluminescence for the lab, scientists worldwide can visualize complex cellular processes, track cancer cells, or map brain activity everyday. 🌟 Our two recent publications bring valuable new insights into the fungal bioluminescence pathway, confirming the exact role that caffeylpyruvate hydrolase (CPH) plays in making fungi glow. For further reading, check out our FEBS Network post here ➡️ buff.ly/G5KBw3p 📖 You can also dive deeper into the full studies, here: - Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway ➡️ buff.ly/DU9DRYh - Fungal oxyluciferin is recycled by caffeylpyruvate hydrolases ➡️ buff.ly/5fkY7fj 🍄Isn't it stunning that some of our most advanced scientific tools come directly from the brilliance of the natural world? We’d love to hear your thoughts, drop them in the comments below! #bioluminescence #fungi #caffeylpyruvatehydrolase #bioluminescencepathway

🚀 We're thrilled to start the week by featuring an exciting new study from the Beck-Sickinger Lab, which presents an innovative approach to a targeted phototoxic peptide. 📕 Targeted, receptor-mediated delivery of a masked d-amino acid cell-penetrating peptide for cell-specific phototoxicity 📖 A targeted phototoxic peptide selectively accumulates in cells expressing chemokine-like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6-tetramethylrhodamine (TMR) labeled nona-ᴅ-arginine which mediates lysosomal rupture and cell death upon irradiation. ✍ Moritz List, Eva-Maria Jülke, Annette Beck-Sickinger Access to the full article, here ➡️ buff.ly/r0CuVqs #peptides #cancer #receptors #sensitizers #drugdelivery

🧬 We look forward to attending the EMBO-EMBL Symposium ‘Mechanobiology across the tree of life’ in Heidelberg next week. 💬 Please come and meet The FEBS Journal Managing Editor, Julija Hmeljak. We'd be delighted to connect and discuss great science with you! #EESMechanobiology #EMBLEvents #FEBSPress

💊 To date, Notch signalling has been thought to occur via ligand and receptor homomers. In this recent study, which led to the discovery of a unique class of NOTCH signalling inhibitors, Liu et al. proposed that NOTCH receptor dimerization/oligomerization is essential for the transactivation of receptor signalling. 📕 Dimerization-dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors 📖 NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has enabled the discovery of a previously unknown class of highly selective NOTCH signalling inhibitors that could underpin novel therapeutic approaches to treating NOTCH-driven pathologies. Access the full article, here 👉 buff.ly/RkOv8Ja ✍ Star Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin-Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel Gonçalves, Peter ten Dijke, David Baker 🌟 You may also read an excellent Commentary article on this study, ✍by Gerard Hoyne 👉buff.ly/8M9Vfwo #notch #receptor #dimerization #therapeutics #signalling

🧬 The Structural Snapshot article in our Issue 10, ✍ by Huma Rahil and Albert Weixlbaumer, delivers a thorough analysis of transcription-translation coupling! 📕 Bridging the gap: When transcription meets translation 📖 Gene expression comprises mRNA transcription from DNA by RNA polymerase, and translation to protein by the ribosome. Bacterial RNA polymerase cooperates with the ribosome in a supramolecular assembly line, which provides new functions. Recently, formation of this complex was visualized, providing insights into mRNA recruitment. RNA polymerase delivers nascent mRNA either directly or via ribosomal protein bS1, which captures and guides mRNA for proper positioning and initiation of translation. Get the comprehensive look, here 👉 buff.ly/F6UDZ6n #transcription #translation #mRNA #polymerase #ribosome